Oral transmucosal absorption of iodine after intraoral preparation with povidone-iodine prior to oral surgeries: a randomized controlled study in 12 male patients

Gou, Liming; Zhao, Rui; Ren, Xiaochun; Li, Yong; Ji, Ping

doi:10.1007/s00784-021-04048-7

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…Our findings are consistent with one study that observed no change in thyroxine levels among 24 men following irrigation of the oral cavity with povidone-iodine compared with those who irrigated with chlorhexidine gluconate [ 21 ]. The lack of change in thyroid function suggests that any increase in circulatory iodine is likely compensated by the autoregulatory function known as the Wolff-Chaikoff effect which prevents thyroid tissues from synthesizing thyroid hormones despite the increased availability of iodine [ 22 ].…”

Section: Discussionsupporting

confidence: 92%

Stable thyroid function despite regular use of povidone-iodine throat spray for SARS-CoV-2 prophylaxis

Quek

Teng

et al. 2022

Annals of Medicine

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Background It is unclear whether unintentional ingestion of povidone-iodine following its application to the oropharyngeal space could affect thyroid function. Objective To examine thyroid function among individuals who regularly apply povidone-iodine throat spray for SARS-CoV-2 prophylaxis. Methods We designed a case-control study to compare thyroid function among participants who received povidone-iodine throat spray three times a day for 42 days (‘cases’) and those who received vitamin C (‘controls’). Thyroid function was assessed by profiling serum TSH, free T3, and free T4; iodine status was estimated using serum thyroglobulin level, while infection status was determined by measuring anti-SARS-CoV-2 antibody against the nucleocapsid antigen. All measurements were performed in pairs, at baseline and 42 days later. Pre-post changes in thyroid function were compared between groups, before and after stratification according to baseline TSH quartiles. Results A total of 177 men (117 cases and 60 controls) (mean age, 32.2 years) were included. Despite comparable demographics and clinical profiles, no clinically or statistically significant differences were observed in thyroid indices between ‘cases’ and ‘controls’ before and after stratification according to TSH quartiles. None of the participants developed symptomatic hypo- or hyperthyroidism throughout the study. Post-hoc analysis did not reveal differences in thyroid function according to infection status. Conclusions Data from this study support the overall safety of povidone-iodine use in the oropharyngeal space for SARS-CoV-2 prophylaxis among individuals with normal thyroid function and subclinical thyroid disease.

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Section: Discussionsupporting

confidence: 92%

Stable thyroid function despite regular use of povidone-iodine throat spray for SARS-CoV-2 prophylaxis

Quek

Teng

et al. 2022

Annals of Medicine

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“…This is related to the long-term lack of systematic research and understanding of transoral bacteriology. To solve the above problems, especially to get more recognition and promotion of transoral approach from spine surgery professionals, we adopt a series of preoperative and intraoperative cleaning and disinfection measures [ 27 , 28 ] and further transform type II incision with relative bacteria in the posterior pharyngeal wall into typeIsterile incision through strict bacteriological evaluation research so as to ensure the safe and effective implementation of transoral internal fixation. Although the number of 20 patients enrolled in this experiment is comparatively small which requires further comprehensive and systematic experimental design and more follow-ups, the successful experience of surgery also reflects that strict preoperative and intraoperative cleaning and disinfection process is effective and safe.…”

Section: Discussionmentioning

confidence: 99%

“…spine surgery professionals, we adopt a series of preoperative and intraoperative cleaning and disinfection measures [27,28] and further transform type II incision with relative bacteria in the posterior pharyngeal wall into typeIsterile incision through strict bacteriological evaluation research so as to ensure the safe and effective n) demonstrate that there is no significant compression of cervical spinal cord at atlantoaxial level, and no significant changes in partial degeneration of spinal cord. X-rays (see o and p) conducted 3 months after the operation show that the internal screw fixed in the atlantoaxial segment is in place without obvious loosening or displacement.…”

Section: Streptococcus Constellatusmentioning

confidence: 99%

Research on pharyngeal bacterial flora in transoral atlantoaxial operation and the postoperative follow-up study

You

Zhou

et al. 2022

BMC Musculoskelet Disord

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Objectives To study the changes of bacterial flora after a series of preoperative oral disinfection and the postoperative recovery of nerve function of patients with craniovertebral junction disorders who were treated with transoral approach operations. Methods This research analyzed 20 cases collected from October 2009 to May 2010. All these patients were with CVJ disorders, including 8 males and 12 females, aged 2 to 66 (38.1 on average), and they were all treated with transoral approach operations. The mucosa samples of the posterior pharyngeal wall were sent for bacteria culture. These samples were collected by sterile cotton swabs at four crucial points, including 3 days before operation/before gargling, 3 days after continuous gargling/after anesthesia intubation on the day of operation, after intraoperative cleaning and washing of the mouth, and after intraoperative iodophor immersion. The microflora was stained by means of smear and further counted after an investigation by microscope. The neural function of patients was evaluated by the ASIA classification and the JOA scores. All patients but two with posterior stabilization performed respectively underwent transoral atlantoaxial reduction plate (TARP) fixation consecutively in the same sitting. A regular reexamination of cervical vertebra with lateral and open mouth X-ray, CT and MRI was conducted after operation to evaluate the reduction of atlantoaxial dislocation, internal fixation position, bone graft fusion, inflammatory lesions and tumor recurrence. Results This bacteriological research showed that the mucosa of the posterior pharyngeal wall of all the patients was in a sterile state after a series of oral preoperative preparations and intraoperative iodophor disinfection, which was considered as type I incision. The bacterial culture results of the mucosa samples of the posterior pharyngeal wall collected at different time points showed significant differences (χ2 = 42.762, P = 0.000). All the patients had improvement in ASIA, and their neural functions were improved to different levels after operation. There was a significant difference in JOA scores before and after operation (t = 8.677, P = 0.000). Postoperative imaging examination showed that the atlantoaxial screw position was good and firm, and the CVJ disorders were treated appropriately. Conclusion It is safe and effective to cut the posterior pharyngeal muscle layer and implant internal fixation by means of transoral approach.

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The role of povidone-iodine in managing of SARS-CoV-2 pandemic

Nasiri¹,

Dimitrova²

2022

Journal of Dental Sciences

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Oral transmucosal absorption of iodine after intraoral preparation with povidone-iodine prior to oral surgeries: a randomized controlled study in 12 male patients

Cited by 5 publications

References 20 publications

Stable thyroid function despite regular use of povidone-iodine throat spray for SARS-CoV-2 prophylaxis

Stable thyroid function despite regular use of povidone-iodine throat spray for SARS-CoV-2 prophylaxis

Research on pharyngeal bacterial flora in transoral atlantoaxial operation and the postoperative follow-up study

The role of povidone-iodine in managing of SARS-CoV-2 pandemic

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