Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in H2O2-Treated Mice

Abstract

Plant-derived exosomes (PDEs) are receiving much attention as a natural source of antioxidants. Previous research has shown that PDEs contain a series of bioactives and that their content varies depending on the fruit or vegetable source. It has also been shown that fruits and vegetables derived from organic agriculture produce more exosomes, are safer, free of toxic substances, and contain more bioactives. The aim of this study was to investigate the ability of orally administered mixes of PDE (Exocomplex®) to restore the physiological conditions of mice treated for two weeks with hydrogen peroxide (H2O2), compared with mice left untreated after the period of H2O2 administration and mice that received only water during the experimental period. The results showed that Exocomplex® had a high antioxidant capacity and contained a series of bioactives, including Catalase, Glutathione (GSH), Superoxide Dismutase (SOD), Ascorbic Acid, Melatonin, Phenolic compounds, and ATP. The oral administration of Exocomplex® to the H2O2-treated mice re-established redox balance with reduced serum levels of both reactive oxygen species (ROS) and malondialdehyde (MDA), but also a general recovery of the homeostatic condition at the organ level, supporting the future use of PDE for health care.

Plant-Derived Exosomes as Novel Nanotherapeutics Contrive Glycolysis Reprogramming-Mediated Angiogenesis for Diabetic Ulcer Healing

“…Nowadays, exosomes derived from medicinal plants that naturally secrete bioactive nanotherapeutics with cell membrane-like structures and stable nanoscale size have been demonstrated for their exceptional biocompatibility, biodegradability, and capability to bypass biological barriers, possessing great potential as therapeutic nanoplatforms for various disease therapies [ 13 – 15 ]. For instance, numerous studies have illustrated that plant-derived exosomes demonstrate remarkable therapeutic effects, including restoring redox balance [ 16 ], anti-leukemic [ 17 ], anti-tumor [ 18 ] properties, and promoting tissue regeneration [ 19 ]. These effects may be attributed to the ability of exosomes to effectively deliver diverse therapeutic payloads, especially small RNAs, to a desired target and influence the diseased cells or tissues [ 20 , 21 ].…”