Oral Treponema denticola Infection Induces Aβ1–40 and Aβ1–42 Accumulation in the Hippocampus of C57BL/6 Mice

Su, Xinyi; Tang, Ziyang; Lu, Zhiyue; Liu, Yuqiu; He, Wanzhi; Jiang, Jiapei; Zhang, Yifan; Wu, Hongkun

doi:10.1007/s12031-021-01827-5

Cited by 31 publications

(33 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been clarified that BBB breakdown is always associated with cognitive decline and AD [ 99 ]. Despite the strong evidence from laboratory-based research [ 8 , 90 ] and the histopathological observations [ 6 ], the role of periodontal spirochaetes, and indeed P. gingivalis , in the pathogenesis of AD is widely underappreciated among the scientific community. The synergism between T. denticola and P. gingivalis in the oral subgingival dysbiotic biofilm may enable the former to regain its motility and move along the neural cells in the surrounding disrupted periodontal tissue via proprioceptors and the trigeminal free nerve endings.…”

Section: Discussion and Implications For Future Researchmentioning

confidence: 99%

“…This oral spirochete can enter the brain and it has been detected in the trigeminal ganglia and in the hippocampus [ 6 ]. An experimentally induced infection of the oral cavity with T. denticola demonstrated the release of Aβ 1–40 and Aβ 1–42 from its parent protein (amyloid precursor protein) due to the activation of β-secretase and γ secretase [ 90 ] and resulted in the promotion of GSK-3β activation and tau phosphorylation [ 8 ].…”

Section: Could the Trigeminal Nerve Pathway Act As The Entrance For ...mentioning

confidence: 99%

See 1 more Smart Citation

The Mechanistic Pathways of Periodontal Pathogens Entering the Brain: The Potential Role of Treponema denticola in Tracing Alzheimer’s Disease Pathology

Pisani

Arcangeli

et al. 2022

IJERPH

View full text Add to dashboard Cite

Alzheimer’s Disease (AD) is a complex neurodegenerative disease and remains the most common form of dementia. The pathological features include amyloid (Aβ) accumulation, neurofibrillary tangles (NFTs), neural and synaptic loss, microglial cell activation, and an increased blood–brain barrier permeability. One longstanding hypothesis suggests that a microbial etiology is key to AD initiation. Among the various periodontal microorganisms, Porphyromonas gingivalis has been considered the keystone agent to potentially correlate with AD, due to its influence on systemic inflammation. P. gingivalis together with Treponema denticola and Tannerella forsythia belong to the red complex consortium of bacteria advocated to sustain periodontitis within a local dysbiosis and a host response alteration. Since the implication of P. gingivalis in the pathogenesis of AD, evidence has emerged of T. denticola clusters in some AD brain tissue sections. This narrative review explored the potential mode of spirochetes entry into the AD brain for tracing pathology. Spirochetes are slow-growing bacteria, which can hide within ganglia for many years. It is this feature in combination with the ability of these bacteria to evade the hosts’ immune responses that may account for a long lag phase between infection and plausible AD disease symptoms. As the locus coeruleus has direct connection between the trigeminal nuclei to periodontal free nerve endings and proprioceptors with the central nervous system, it is plausible that they could initiate AD pathology from this anatomical region.

show abstract

Section: Discussion and Implications For Future Researchmentioning

confidence: 99%

Section: Could the Trigeminal Nerve Pathway Act As The Entrance For ...mentioning

confidence: 99%

The Mechanistic Pathways of Periodontal Pathogens Entering the Brain: The Potential Role of Treponema denticola in Tracing Alzheimer’s Disease Pathology

Pisani

Arcangeli

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…The role of T. denticola in cognitive function has not been studied as much as P. gingivalis . Su et al (2021) demonstrated that T. denticola could enter the brain, act directly on nerve cells, and result in intra- and extracellular Aβ 1-40 and Aβ 1-42 accumulation in the hippocampus of C57BL/6 mice [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

The Red and Orange Complex Subgingival Microbiome of Cognitive Impairment and Cognitively Normal Elderly with Periodontitis

et al. 2022

View full text Add to dashboard Cite

Increasing evidence has shown an association between periodontitis and cognitive impairment. Subgingival microbiota play a great role in periodontitis pathogenesis. However, the correlation between the subgingival microbiome and cognitive impairment remains unclear. This study aimed to evaluate the red and orange complex subgingival microbiome of cognitively impaired and cognitively normal elderly Indonesian subjects with periodontitis. Twenty-eight elderly subjects diagnosed with periodontitis underwent two cognitive examinations using the Hopkins Verbal Learning Test and the Mini-Mental State Examination. Gingival crevicular fluid taken from the periodontal pocket, at a depth between 5 and 7 mm, using a paper point was used as the subgingival samples. The subgingival microbiome in the cognitive impairment group (n = 14) and cognitively normal group (n = 14) was compared using the 16S rRNA Metagenomic iSeq™ 100 Sequencing System. There was β-diversity in the subgingival microbiota between the cognitively impaired and cognitively normal subjects. The metagenomic analysis showed a higher abundance of Porphyromonas and Treponema bacteria in the cognitive impairment group than in the normal cognitive group (p < 0.05). The abundance of Porphyromonas gingivalis and Treponema denticola was higher in the cognitively impaired elderly subjects. The role of P. gingivalis and T. denticola in the pathogenesis of cognitive impairment needs further investigation.

show abstract

“…A 2021 report revealed T. denticola as a potential contributing factor, along with P. gingivalis , as risk factors for AD. The research group found that T. denticola had the ability to enter the brain and increased the expression of amyloid-β (the hallmark in AD), although the mechanism is unclear [ 66 ].…”

Section: Health Issues Affecting Alzheimer's Diseasementioning

confidence: 99%

Alzheimer's Disease and Oral-Systemic Health: Bidirectional Care Integration Improving Outcomes

Rice¹

2021

Front. Oral. Health

View full text Add to dashboard Cite

Dentistry is an effective healthcare field that can impact Alzheimer's disease through prevention and education. Every day dental providers use an arsenal of assessment protocols directly coinciding with modifiable Alzheimer's risk factors. An innovative way to help in the prevention of Alzheimer's disease is to utilize oral health professionals who reach the public in ways other health care providers may not. Bidirectional care integration is needed to stifle many systemic diseases and Alzheimer's disease is no different. Ultimately with collaborative care the patient reaps the benefits. Alzheimer's is associated with many etiologies and pathophysiological processes. These include cardiovascular health, smoking, sleep, inflammatory pathogens, and diabetes. In the United States, dental providers assess each of these factors daily and can be instrumental in educating patients on the influence of these factors for dementia prevention. Globally, by 2025, the number of people with Alzheimer's disease is expected to rise by at least 14%. Such increases will strain local and national health care systems, but for the US if Medicare were expanded to include dental services, many older adults could be spared needless suffering. The goal of this perspective article is to highlight existing practices being used in the field of dentistry that can easily be adapted to educate patients in preventive care and treat risk factors. It is the duty of healthcare professionals to explore all opportunities to stem the advance of this disease and by integrating oral and systemic health into transdisciplinary science, health care and policy may do just that.

show abstract

Oral Treponema denticola Infection Induces Aβ1–40 and Aβ1–42 Accumulation in the Hippocampus of C57BL/6 Mice

Cited by 31 publications

References 30 publications

The Mechanistic Pathways of Periodontal Pathogens Entering the Brain: The Potential Role of Treponema denticola in Tracing Alzheimer’s Disease Pathology

The Mechanistic Pathways of Periodontal Pathogens Entering the Brain: The Potential Role of Treponema denticola in Tracing Alzheimer’s Disease Pathology

The Red and Orange Complex Subgingival Microbiome of Cognitive Impairment and Cognitively Normal Elderly with Periodontitis

Alzheimer's Disease and Oral-Systemic Health: Bidirectional Care Integration Improving Outcomes

Contact Info

Product

Resources

About