Oral tributyrin prevents endotoxin-induced lipid metabolism disorder

Miyoshi, Makoto; Iizuka, Norihito; Sakaï, Shota; Fujiwara, Mayu; Ishikawa, Michiko; Maeshige, Noriaki; Hamada, Y.; Takahashi, Michiko; Usami, Makoto

doi:10.1016/j.clnesp.2015.02.001

Cited by 13 publications

(8 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although indirect, it can be of importance to discuss the reduced liver triglycerides in association with activation of peroxisome proliferator-activated receptor alpha (PPARα), a ligand-activated transcription factor involved in regulation of genes that stimulate removal of triglycerides from the bloodstream and enhance β-oxidation in the liver. Tributyrin, a similar sibling of monobutyrin, has been shown to increase mRNA and protein expression of PPARα, and β-oxidation related genes in rat liver [33]. These effects were mediated by increased acetylation of histone H3 in the liver, subsequently leading to inhibition of inflammatory markers and liver injury, and reduced levels of plasma triglycerides, total and LDL-cholesterol after 24 h LPS challenge.…”

Section: Discussionmentioning

confidence: 99%

“…A complete answer cannot be achieved with the design and aim of this study since it is not known whether the enzymatic hydrolysis of MB to butyric acid is complete or not. However, taking into account reported positive effects of MB and tributyrin on cecal microbiota composition, liver lipids, high-fat diet-induced inflammation, and gut barrier function [9,17,33,38], it can be suggested that mechanisms responsible for the effects of MB are possibly related to main functions of butyric acid, i.e., inhibition of histone deacetylase and regulation of receptor-mediated signaling. A summary of effects and mechanisms of MB is illustrated in Figure 6.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Monobutyrin Reduces Liver Cholesterol and Improves Intestinal Barrier Function in Rats Fed High-Fat Diets

et al. 2019

View full text Add to dashboard Cite

Butyric acid has been shown to reduce high-fat diet-related metabolic disturbances and to improve intestinal barrier function due to its potent anti-inflammatory capacity. This study investigates whether a butyric acid ester, monobutyrin (MB) affects lipid profiles and gut barrier function in a dose-response manner in rats fed butter- or lard-based high-fat diets. Four-week-old male Wistar rats were fed butter-based diets containing 0, 0.25, 0.75 and 1.5 MB g/100 g (dry weight basis) or 0.5 glycerol g/100 g, and diets with lard (La) containing 0 and 0.5 MB g/100 g or a low-fat control diet for 3–4 weeks. Lipid profiles in blood and liver tissue, intestinal permeability and cecal short-chain fatty acids were examined. The results showed a dose-dependent decrease in liver total cholesterol for 1.5 MB (p < 0.05) and liver triglycerides for 0.75 MB (p < 0.05) and 1.5 MB (p = 0.08) groups compared to the high-fat control group. Furthermore, a lower excretion of mannitol in urine in the 1.5 MB group indicated improved intestinal barrier function. When MB was supplemented in the lard-based diet, serum total cholesterol levels decreased, and total amount of liver high-density lipoprotein-cholesterol increased. Thus, MB dietary supplementation can be effective in counteracting lipid metabolism disturbances and impaired gut barrier function induced by high-fat diets.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Monobutyrin Reduces Liver Cholesterol and Improves Intestinal Barrier Function in Rats Fed High-Fat Diets

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Ohhira et al (Ohhira et al, ) showed that injection of LPS transiently induced lipid accumulation in hepatocytes, especially around the portal vein of mice. Miyoshi et al () also found that LPS injection increased the plasma triacylglycerol (TAG) and total cholesterol (TC) levels at 24 h in rats. These observations highlighted that LPS leads to liver injury and lipid metabolism disorder (Affò et al, ; Zhang, Xu, et al, ).…”

Section: Introductionmentioning

confidence: 94%

Curcumin Attenuates Lipopolysaccharide‐Induced Hepatic Lipid Metabolism Disorder by Modification of m⁶A RNA Methylation in Piglets

Lü

et al. 2018

Lipids

103

View full text Add to dashboard Cite

N -methyladenosine (m A) regulates gene expression and affects cellular metabolism. In this study, we checked whether the regulation of lipid metabolism by curcumin is associated with m A RNA methylation. We investigated the effects of dietary curcumin supplementation on lipopolysaccharide (LPS)-induced liver injury and lipid metabolism disorder, and on m A RNA methylation in weaned piglets. A total of 24 Duroc × Large White × Landrace piglets were randomly assigned to control, LPS, and CurL (LPS challenge and 200 mg/kg dietary curcumin) groups (n = 8/group). The results showed that curcumin reduced the increase in relative liver weight as well as the concentrations of aspartate aminotransferase and lactate dehydrogenase induced by LPS injection in the plasma and liver of weaning piglets (p < 0.05). The amounts of total cholesterol and triacylglycerols were decreased by curcumin compared to that by the LPS injection (p < 0.05). Additionally, curcumin reduced the expression of Bcl-2 and Bax mRNA, whereas it increased the p53 mRNA level in the liver (p < 0.05). Curcumin inhibited the enhancement of SREBP-1c and SCD-1 mRNA levels induced by LPS in the liver. Notably, dietary curcumin affected the expression of METTL3, METTL14, ALKBH5, FTO, and YTHDF2 mRNA, and increased the abundance of m A in the liver of piglets. In conclusion, the protective effect of curcumin in LPS-induced liver injury and hepatic lipid metabolism disruption might be due to the increase in m A RNA methylation. Our study provides mechanistic insights into the effect of curcumin in protecting against hepatic injury during inflammation and metabolic diseases.

show abstract

“…On the other hand, recent study on Tributyrin also prove that it can reduce the cholesterol level. Makata et al [8] study the effect of oral consumption of Tributyrin toward the level of plasma triglyceride, total cholesterol and low-density lipoprotein cholesterol in rat. The clinical research shows that Tributyrin is important for health science area.…”

Section: Resultsmentioning

confidence: 99%

Compounds Identification in Agar Wood Soaking Water by Using GC-MS

Jok¹,

Zainudin²,

Radzi³

et al. 2016

IJCEA

View full text Add to dashboard Cite

Oral tributyrin prevents endotoxin-induced lipid metabolism disorder

Cited by 13 publications

References 28 publications

Monobutyrin Reduces Liver Cholesterol and Improves Intestinal Barrier Function in Rats Fed High-Fat Diets

Monobutyrin Reduces Liver Cholesterol and Improves Intestinal Barrier Function in Rats Fed High-Fat Diets

Curcumin Attenuates Lipopolysaccharide‐Induced Hepatic Lipid Metabolism Disorder by Modification of m⁶A RNA Methylation in Piglets

Compounds Identification in Agar Wood Soaking Water by Using GC-MS

Contact Info

Product

Resources

About

Oral tributyrin prevents endotoxin-induced lipid metabolism disorder

Cited by 13 publications

References 28 publications

Monobutyrin Reduces Liver Cholesterol and Improves Intestinal Barrier Function in Rats Fed High-Fat Diets

Monobutyrin Reduces Liver Cholesterol and Improves Intestinal Barrier Function in Rats Fed High-Fat Diets

Curcumin Attenuates Lipopolysaccharide‐Induced Hepatic Lipid Metabolism Disorder by Modification of m6A RNA Methylation in Piglets

Compounds Identification in Agar Wood Soaking Water by Using GC-MS

Contact Info

Product

Resources

About

Curcumin Attenuates Lipopolysaccharide‐Induced Hepatic Lipid Metabolism Disorder by Modification of m⁶A RNA Methylation in Piglets