Oral Trypanosoma cruzi Transmission Resulting in Advanced Chagasic Cardiomyopathy in an 11-Month-Old Male

Nolan, Melissa S.; Mendes, Joseane Elza Tonussi; Riera, Andrés Ricardo Pérez; Laporta, Gabriel Zorello

doi:10.1155/2020/8828950

Cited by 3 publications

(4 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Children are a particularly vulnerable population to oral transmission [7,8], which is concerning given the higher symptomology rate associated with this transmission route [21,23,34]. Lastly, despite the large-scale Pan American Health Organization vector control efforts of the 1990s and 2000s, children are still being infected with Chagas disease at unacceptable levels [35,36].…”

Section: Discussionmentioning

confidence: 99%

“…Further, infected patients that acquire disease orally present with greater acute disease symptomology and occur in communal outbreaks [3][4][5]. Children are particularly vulnerable to severe disease and death from orally transmitted Chagas disease [6][7][8]. The geographic location of triatomine species associated with food/beverage product is largely unknown but has been reported in the Amazonian region of Venezuela-Brazil, Peru, and Colombia [2].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acute Pediatric Chagas Disease in Antioquia, Colombia: A Geographic Location of Suspected Oral Transmission

et al. 2021

Self Cite

View full text Add to dashboard Cite

Chagas disease, Trypanosoma cruzi infection, is an insidious cause of heart failure in Latin America. Early diagnosis and treatment are critical to prevent irreversible myocardial damage that progressively accumulates over decades. Several structural barriers account for the less than 1% of cases in Colombia being treated, including poor physician knowledge, especially considering that some regions are considered non-endemic. The two cases reported here represent an emerging epidemiologic scenario associated with pediatric Chagas disease. Both cases are suspected oral transmitted parasitic infection in a geographic region of Colombia (Andean region of Antioquia) where no previous oral transmission of Chagas disease had been reported. Their clinical histories and course of disease are presented here to increase physician awareness of the epidemiologic risk factors and clinical manifestations associated with pediatric oral Chagas disease in Antioquia department, Colombia.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acute Pediatric Chagas Disease in Antioquia, Colombia: A Geographic Location of Suspected Oral Transmission

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…In an experimental study, they observed the parasite to survive between 24 and 72 h in several drinks, including mandarin, guayaba, and guanabana, and up to 384 h in guanabana when preserved at 4 °C; results were reproduced in a separate study with similar conditions for açai juice [ 65 , 66 ]. Further, some populations culturally use açai juice as a way to wean infants off breastmilk, and infants have developed Chagas cardiomyopathy following consumption of contaminated açai juice [ 67 ]. Considering juices are usually consumed within a short amount of time after preparation, it is important to note how 24 h would make this transmission route feasible and the most likely.…”

Section: T Cruzi Contaminated Food and Drinkmentioning

confidence: 99%

Oral Chagas Disease in Colombia—Confirmed and Suspected Routes of Transmission

Beatty,

Arango-Ferreira,

Gual-Gonzalez

et al. 2024

TropicalMed

View full text Add to dashboard Cite

Chagas disease (CD) remains endemic throughout many regions of Colombia despite implementing decades of vector control strategies in several departments. Some regions have had a significant decrease in vectorial transmission, but the oral ingestion of Trypanosoma cruzi through consumption of contaminated food and drink products is increasingly described. This form of transmission has important public health relevance in Colombia due to an increase in reported acute CD cases and clinical manifestations that often lead to significant morbidity and mortality. Oral CD in Colombia has been associated with the consumption of contaminated fruit juices, such as palm wine, sugar cane, or tangerine juice and water for consumption, or contaminated surfaces where food has been prepared. Another interesting route of oral transmission includes ingestion of unbeknownst infected armadillos’ blood, which is related to a traditional medicine practice in Colombia. Some earlier reports have also implemented consumption of infected bush meat as a source, but this is still being debated. Within the Amazon Basin, oral transmission is now considered the principal cause of acute CD in these regions. Furthermore, new cases of acute CD are now being seen in departments where CD has not been documented, and triatomine vectors are not naturally found, thus raising suspicion for oral transmission. The oral CD could also be considered a food-borne zoonosis, and odoriferous didelphid secretions have been implemented in contaminating the human dwelling environment, increasing the risk of consumption of infectious metacyclic trypomastigotes. In this article, we will discuss the complex transmission dynamics of oral CD in Colombia and further examine the unique clinical manifestations of this route of infection. New insights into the oral transmission of Trypanosoma cruzi are being discovered in Colombia, which can help bring increased awareness and a better understanding of this neglected tropical disease to reduce the burden of CD throughout Latin America.

show abstract

“…In general, mortality from vector-borne transmission ChD is estimated to be between 5% and 10%, whereas ChD from the foodborne infection route is estimated to be associated with 8% to 40% mortality [34], with children, pregnant or postpartum women, and the elderly accounting for most fatalities [35]. Whereas acute ChD in childhood due to vector-borne transmission often presents as a nonspecific, flu-like disease, infection via oral transmission causes more severe symptoms; fatality during acute ChD is not uncommon, particularly in children [35][36][37][38].…”

Section: Routes Of Transmission Of Chdmentioning

confidence: 99%

The importance of estimating the burden of disease from foodborne transmission of Trypanosoma cruzi

Robertson,

Havelaar,

Keddy

et al. 2024

PLoS Negl Trop Dis

View full text Add to dashboard Cite

Chagas disease (ChD), caused by infection with the flagellated protozoan, Trypanosoma cruzi, has a complicated transmission cycle with many infection routes. These include vector-borne (via the triatomine (reduviid bug) vector defecating into a skin abrasion, usually following a blood meal), transplacental transmission, blood transfusion, organ transplant, laboratory accident, and foodborne transmission. Foodborne transmission may occur due to ingestion of meat or blood from infected animals or from ingestion of other foods (often fruit juice) contaminated by infected vectors or secretions from reservoir hosts. Despite the high disease burden associated with ChD, it was omitted from the original World Health Organization estimates of foodborne disease burden that were published in 2015. As these estimates are currently being updated, this review presents arguments for including ChD in new estimates of the global burden of foodborne disease. Preliminary calculations suggest a burden of at least 137,000 Disability Adjusted Life Years, but this does not take into account the greater symptom severity associated with foodborne transmission. Thus, we also provide information regarding the greater health burden in endemic areas associated with foodborne infection compared with vector-borne infection, with higher mortality and more severe symptoms. We therefore suggest that it is insufficient to use source attribution alone to determine the foodborne proportion of current burden estimates, as this may underestimate the higher disability and mortality associated with the foodborne infection route.

show abstract

Oral Trypanosoma cruzi Transmission Resulting in Advanced Chagasic Cardiomyopathy in an 11-Month-Old Male

Cited by 3 publications

References 20 publications

Acute Pediatric Chagas Disease in Antioquia, Colombia: A Geographic Location of Suspected Oral Transmission

Acute Pediatric Chagas Disease in Antioquia, Colombia: A Geographic Location of Suspected Oral Transmission

Oral Chagas Disease in Colombia—Confirmed and Suspected Routes of Transmission

The importance of estimating the burden of disease from foodborne transmission of Trypanosoma cruzi

Contact Info

Product

Resources

About