Oral vaccine delivery

Russell-Jones, G.J.

doi:10.1016/s0168-3659(99)00231-x

Cited by 83 publications

(30 citation statements)

References 26 publications

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“…So far, some of conventional colloidal drug-delivery systems, such as liposomes and nanoparticles, have been developed and tested for PPD. [1][2][3] However, the bioavailability of peptide after oral administration is usually low due to instability and poor absorption of proteins in the gastrointestinal tract. One possible way to improve the gastrointestinal uptake of peptides is to encapsulate them in colloidal nanoparticles that can protect the peptide from being degraded in the gastrointestinal tract and facilitate their transportation into systemic circulation.…”

Section: Introductionmentioning

confidence: 99%

Quaternized chitosan (QCS)/poly (aspartic acid) nanoparticles as a protein drug-delivery system

Wang

et al. 2009

Carbohydrate Research

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Section: Introductionmentioning

confidence: 99%

Quaternized chitosan (QCS)/poly (aspartic acid) nanoparticles as a protein drug-delivery system

Wang

et al. 2009

Carbohydrate Research

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“…29,30 Interaction with pathogens or antigens can produce the IgA secretion as an antibody response. 31 Intracellular antigens, can be produced by invading viruses that replicate within the host cell, or derive from cytoplasmic bacteria, while the extracellular antigens include bacteria, parasites, and toxins in the tissues. Intracellular antigens are generally processed in the host cells, coupled to a major histocompatibility complex-I (MHC-I), a cell surface molecule, and transported to the cell surface.…”

Section: Respiratory Epithelial Cellsmentioning

confidence: 99%

Current prospects and future challenges for nasal vaccine delivery

Yusuf

Kett

2016

Human Vaccines & Immunotherapeutics

124

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Nasal delivery offers many benefits over traditional approaches to vaccine administration. These include ease of administration without needles that reduces issues associated with needlestick injuries and disposal. Additionally, this route offers easy access to a key part of the immune system that can stimulate other mucosal sites throughout the body. Increased acceptance of nasal vaccine products in both adults and children has led to a burgeoning pipeline of nasal delivery technology. Key challenges and opportunities for the future will include translating in vivo data to clinical outcomes. Particular focus should be brought to designing delivery strategies that take into account the broad range of diseases, populations and healthcare delivery settings that stand to benefit from this unique mucosal route. In this review the current state of the art in nasal vaccine delivery will be described along with future prospects. A brief introduction to the anatomy and physiology of the nasal cavity will highlight the advantages and disadvantages of the route. Encapsulation and presentation methods along with particular formulation considerations for the nasal route will also be discussed.There are many mucosal routes which have been regarded as potential sites for vaccine delivery such as oral, nasal, pulmonary, conjunctival, rectal and vaginal mucosa. However, for practical and cultural reasons researchers have tended to focus only on oral, nasal, and pulmonary administration. 1 Needlefree vaccines offer many advantages over traditional vaccination approaches including convenience, cost, ease of administration and disposal.There are several needle free methods of vaccination such as transdermal delivery and mucosal delivery. 2,3 Mucosal immunization has been successfully used in human vaccination. The human mucosal immune system is large and specialized in performing inspection for foreign antigens to protect the surfaces themselves and of course human body interior. Since most infections affect or start from mucosal surfaces, using a mucosal route of vaccination is of great interest and provides a rational reason to induce a protective immune response. 3 Nasal delivery of vaccine offers an easily accessible route to the immune system.The nose has the function of olfactory detection (sense of smell) and also filtration, humidification and temperature control of air as it enters the respiratory system. Moving from front to back the areas of the nasal cavity are the nasal vestibule, the respiratory region, and the olfactory region. The nasal cavity is divided by the septum to form the left and right nares, which lead into the left and right choana before opening onto the nasopharynx at the top of the throat. The turbinates bound the nasal walls and are responsible for air conditioning and the large mucosal surface area of the nasal cavity. The nose is also the main port of entry for many pathogens. The first barrier to foreign bodies is hair at the entrance to the nares, the nostrils, which successfully keeps ou...

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“…This may be accompanied by the development of systemic tolerance to the fed antigen and thus a serum antibody response to the antigen is not elicited. (128) Early clinical trials have shown that oral vaccines can induce a modest degree of antibody-based immune response, (63) but their capacity to completely protect against disease still remains unproven. Thus, investment in oral vaccines will only succeed with continued efforts to design better delivery vehicles and to understand the mechanism of action of these formulations.…”

Section: Measlesmentioning

confidence: 99%

Oral vaccines: new needs, new possibilities

et al. 2007

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Vaccination is an important tool for handling healthcare programs both in developed and developing countries. The current global scenario calls for a more-efficacious, acceptable, cost-effective and reliable method of immunization for many fatal diseases. It is hoped that the adoption of oral vaccines will help to provide an effective vaccination strategy, especially in developing countries. Mucosal immunity generated by oral vaccines can serve as a strong first line of defense against most of the pathogens infecting through the mucosal lining. Advances in elucidating the mechanism of action of oral vaccines will facilitate the design of more effective, new generation vaccines. There are promising developments in the use of different agents to effectively deliver the vaccine candidate. It is hoped that ongoing research may be able to set another cardinal point, after polio vaccine, in eradicating infectious diseases.

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Oral vaccine delivery

Cited by 83 publications

References 26 publications

Quaternized chitosan (QCS)/poly (aspartic acid) nanoparticles as a protein drug-delivery system

Quaternized chitosan (QCS)/poly (aspartic acid) nanoparticles as a protein drug-delivery system

Current prospects and future challenges for nasal vaccine delivery

Oral vaccines: new needs, new possibilities

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