Oral vaccines: Design and delivery

Gilligan, C.A.; Po, A. Li Wan

doi:10.1016/0378-5173(91)90246-k

Cited by 42 publications

(8 citation statements)

References 95 publications

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“…The immune response is stimulated when antigens gain access to lymphoid tissue within the GIT. The gutassociated lymphoid tissue is distributed into four anatomic regions [87]: the lamina propria, which contains large numbers of plasma cells as well as macrophages, neutrophils, eosinophilis, and mast cells; the intraepithelial lymphocytes, which are dispersed between the epithelial cells of the mucosal membrane; isolated lymphoid follicles, present throughout the intestine and colon; PP, which are clusters of lymphoid follicles along the wall of the small intestine [88]. Lymphoid tissue of the lamina propria and intraepithelial lymphocytes are collectively known as the diffuse lymphoid tissue.…”

Section: Vaccinesmentioning

confidence: 99%

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Nanoencapsulation II. Biomedical applications and current status of peptide and protein nanoparticulate delivery systems

Reis

Neufeld

Ribeiro

et al. 2006

Nanomedicine: Nanotechnology, Biology and Medicine

188

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The concept of polymeric nanoparticles for the design of new drug delivery systems emerged a few years ago, and recent rapid advances in nanotechnology have offered a wealth of new opportunities for diagnosis and therapy of various diseases. Recent progress has made possible the engineering of nanoparticles to allow the site-specific delivery of drugs and to improve the pharmacokinetic profile of numerous compounds with biomedical applications such as peptide and protein drugs. Biologically active peptides and their analogues are becoming an increasingly important class of drugs. Their use for human and animal treatment is problematic, however, because some of these drugs are generally ineffective when taken orally and thus have been administered chiefly by the parenteral route. This review covers some of the historical and recent advances of nanotechnology and concludes that polymeric nanoparticles show great promise as a tool for the development of peptide drug delivery systems.

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Section: Vaccinesmentioning

confidence: 99%

“…Lymphoid tissue of the lamina propria and intraepithelial lymphocytes are collectively known as the diffuse lymphoid tissue. An immune response is elicited through lymphoid tissue of the PP and isolated lymphoid follicles [88].…”

Section: Vaccinesmentioning

confidence: 99%

Nanoencapsulation II. Biomedical applications and current status of peptide and protein nanoparticulate delivery systems

Reis

Neufeld

Ribeiro

et al. 2006

Nanomedicine: Nanotechnology, Biology and Medicine

188

View full text Add to dashboard Cite

show abstract

“…The relative contributions of microbial attachment mechanisms and of host antigen sampling and uptake mechanisms have remained uncertain for pathogens such as salmonella, because of the known capability of M cells for taking up noninvasive bacteria such as Vibrio cholerae (15). be important in devising better vaccines against S. typhi, and also in engineering salmonella mutants capable of carrying bacterial and viral immunogens of interest, including HIV surface antigens (16). Recombinant gene expression technology is now being used to introduce foreign bacterial, parasitic, and viral antigens into attenuated strains of S. typhimurium, which can colonize gut-associated lymphoid tissues, with the aim of initiating immune responses, protective for mucosal surfaces that are the entry pathways for most pathogens (17,18).…”

mentioning

confidence: 99%

M cells--entryways of opportunity for enteropathogens.

Owen

1994

The Journal of Experimental Medicine

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“…Furthermore, microparticles, nanoparticles and liposomes have been widely studied as an oral delivery system for vaccines (Morishita et al, 1992). Gilligan et al (1991) stated that microparticles and nanoparticles will substantially influence the development of both oral and parenteral vaccines in the future. However, particular emphasis must be placed on the use of biodegradable and biocompatible polymers as in the case of the azo-polymer.…”

Section: Discussionmentioning

confidence: 99%

Preparation and Evaluation of a Time-Controlled Release Capsule Made of Ethylcellulose for Colon Delivery of Drugs

Niwa

Takaya

Morimoto

et al. 1995

Journal of Drug Targeting

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A novel ethylcellulose (EC) capsule which releases drug with a time-controlled fashion has been prepared. This capsule is composed of four parts, drug container, swellable substance, capsule body and cap. At the bottom of the body, micropores are made. As water penetrates through these micropores, the swellable substance such as low substituted hydroxypropyl cellulose (L-HPC) swells. When the cap made of water-insoluble macromolecular substance such as EC cannot persist the swelling pressure, the EC cap disintegrates and the drug in the container is released from the capsule. The lag-time is utilized for the delivery of drug to the colon. The release time of the drug from the capsule was measured both in vitro and in vivo experiments. In the case of an in vitro experiment, after 12mg of fluorescein as a model drug and 238mg of starch were filled into the container, caps having different thickness were attached to the capsule body and release study was performed. The release time of the drug was mainly dependent on the thickness of the cap. Using test capsules of which mean cap thickness were 39.1 +/- 2.3 (SE)microns, 63.1 +/- 5.0 microns and 75.6 +/- 4.1 microns, the in vivo release time was estimated after administration to beagle dogs. As a parameter, the peak time (tmax) when plasma fluorescein concentration reached to its maximum level was determined for the estimation of the release time of the drug from the capsule in the gastrointestinal tract. The in vivo tmax was well correlated with the cap thickness.(ABSTRACT TRUNCATED AT 250 WORDS)

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Oral vaccines: Design and delivery

Cited by 42 publications

References 95 publications

Nanoencapsulation II. Biomedical applications and current status of peptide and protein nanoparticulate delivery systems

Nanoencapsulation II. Biomedical applications and current status of peptide and protein nanoparticulate delivery systems

M cells--entryways of opportunity for enteropathogens.

Preparation and Evaluation of a Time-Controlled Release Capsule Made of Ethylcellulose for Colon Delivery of Drugs

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