Oral verruca vulgaris in a bone marrow transplant patient: A case report and review of literature

Barasch, Andrei; Eisenberg, Ellen; D'Ambrosio, Joseph A.; Nuki, Klaus; Peterson, D.E.

doi:10.1016/0964-1955(95)00072-0

Cited by 8 publications

(3 citation statements)

References 9 publications

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“…Patients with increased cutaneous HPV lesions will often demonstrate oral lesions. A case of rapidly enlarging, biopsy-documented oral verruca vulgaris in a patient undergoing myeloablative HSCT has been reported [ 187 ].…”

Section: Infectionsmentioning

confidence: 99%

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

Haverman

Raber-Durlacher

Rademacher

et al. 2014

Mediators of Inflammation

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Hematopoietic stem cell transplantation (HSCT) is widely used as a potentially curative treatment for patients with various hematological malignancies, bone marrow failure syndromes, and congenital immune deficiencies. The prevalence of oral complications in both autologous and allogeneic HSCT recipients remains high, despite advances in transplant medicine and in supportive care. Frequently encountered oral complications include mucositis, infections, oral dryness, taste changes, and graft versus host disease in allogeneic HSCT. Oral complications are associated with substantial morbidity and in some cases with increased mortality and may significantly affect quality of life, even many years after HSCT. Inflammatory processes are key in the pathobiology of most oral complications in HSCT recipients. This review article will discuss frequently encountered oral complications associated with HSCT focusing on the inflammatory pathways and inflammatory mediators involved in their pathogenesis.

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Section: Infectionsmentioning

confidence: 99%

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

Haverman

Raber-Durlacher

Rademacher

et al. 2014

Mediators of Inflammation

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“…Oral verrucas and papillomas have been noted in bone marrow transplant recipients 1-3 years post-transplantation [8,61]. Barasch et al [8] described a patient who developed a rapidly growing oral verruca prior to bone marrow transplantation. The presence of HPV was confirmed by immunohistochemistry of HPV capsid antigens.…”

Section: Immunosuppression and Oral Hpvmentioning

confidence: 99%

Human papillomavirus infections and oral tumors

Syrjänen

2003

Medical Microbiology and Immunology

146

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In the past 20 years, there has been an increasing interest in human papillomaviruses (HPV) because of their potential role in the pathogenesis of malignant tumors. In 1983, we published the first evidence that HPV might be involved in oral squamous cell carcinomas. The identification of morphological similarities between oral and cervical mucosa lead us to this original proposal. In a recent meta-analysis, HPV was indeed confirmed as an independent risk factor for oral carcinoma. To date, totally more than 100 types of HPV have been identified. As in anogenital cancers, HPV type 16 is the most prevalent type in oral carcinomas. The benign oral lesions, associated with HPV infection, include squamous cell papilloma, condyloma acuminatum, verrucca vulgaris and focal epithelial hyperplasia (FEH). Papillomas and condylomas are mostly caused by HPV type 6 or 11, while oral verrucas are associated with the skin types 2 or 4. A family history of FEH has been suggested. The FEH lesions are caused by HPV types 13 and 32, only detected in oral epithelium. In immunocompromised patients, benign HPV-induced lesions are characterized by atypical morphology and the simultaneous detection of multiple HPV types. Oral benign HPV lesions are mostly asymptomatic, and may persist or regress spontaneously.

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“…Viral infections are a complication of allogenic HSCT. HPV was documented in a biopsy of oral verruca vulgaris in a patient undergoing myeloablative HSCT . In Addition, it was detected in two OSCC cases who are post allogenic HSCT .…”

Section: Discussionmentioning

confidence: 96%

HPV‐related oral dysplasia in a multiple myeloma patient after stem cell transplantation

Saleh

Cha

Bhattacharyya

et al. 2018

Special Care in Dentistry

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The development of dysplastic changes in oral epithelial lesions is a potential longterm complication after hematopoietic stem cell transplantation (HSCT). This may be related to mechanisms including radiation and chemotherapy regimens, chronic graftversus-host disease (cGVHD), inflammation, and prolonged immunosuppression. The current case describes a 54-year-old male with multiple myeloma treated by autologous and allogenic HSCT followed by development of cGVHD (mouth, skin and the eyes) with the complaint of diffuse white lesions on the buccal mucosa, tongue, and palate. A biopsy performed with histopathological analysis revealed moderate to severe epithelial dysplasia with hyperkeratosis, positive for p16INK4A as a surrogate marker for human papillomavirus (HPV). Our finding suggests a possible association of oral dysplasia and HPV in patients after receiving allogenic HSCT with the necessity of more clinical follow-ups for those patients that may be at a higher risk for the development of oral dysplasia associated with HPV.

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Oral verruca vulgaris in a bone marrow transplant patient: A case report and review of literature

Cited by 8 publications

References 9 publications

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

Oral Complications in Hematopoietic Stem Cell Recipients: The Role of Inflammation

Human papillomavirus infections and oral tumors

HPV‐related oral dysplasia in a multiple myeloma patient after stem cell transplantation

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