Oral Verruciform Xanthoma: A Clinicopathologic Study of 15 Cases

Yu, Chuan‐Hang; Tsai, Tung-Chieh; Wang, Jeng-Tzung; Liu, Bu-Yuan; Wang, Yiping; Sun, Andy; Chiang, Chun‐Pin

doi:10.1016/s0929-6646(09)60230-8

Cited by 44 publications

(63 citation statements)

References 22 publications

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“…Human papillomavirus (HPV) has not been demonstrated in VX lesions and viral particles have not been identified ultrastructurally. 7 Based on light and electron microscopic studies, Zegarelli et al proposed that foam cells are lipid-laden macrophages and oral VX may develop as a consequence of epithelial entrapment with subsequent degeneration and lipid accumulation. 8 They suggested a local irritant as the initiator of the disease process, because oral VX is frequently found on masticatory mucosa where localized trauma is very common.…”

Section: Discussionmentioning

confidence: 99%

“…They suggested that an immune response may play a role in VX pathogenesis. 7,8 Zegarelli et al introduced the concept that the cause of accumulation of lipid-containing macrophages is epithelial degeneration. The products of epithelial breakdown elicit an inflammatory response which is manifested by a predominant neutrophil infiltrate in the epithelium and a subsequent release of lipid material through the epithelium which finally is scavenged by the macrophages.…”

Section: Discussionmentioning

confidence: 99%

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Verruciform Xanthoma-Histopathologically: A Distinct Entity

Pawar¹

2014

Journal of Contemporary Dentistry

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Verruciform Xanthoma-Histopathologically: A Distinct Entity

Pawar¹

2014

Journal of Contemporary Dentistry

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“…Histologically, VX shows three patterns: verrucous (most common), flat, and papillary (least common) [16,17]. There is parakeratosis of the hyperplastic epithelium which is variable in extent and is usually more marked in the verrucous and papillary patterns.…”

Section: Discussionmentioning

confidence: 99%

Oral verruciform xanthoma: a case report and literature review

2012

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Verruciform xanthoma is a benign mucocutaneous, uncommon, nonsymptomatic lesion of uncertain etiopathology, which occurs mostly on the oral mucosa of middle-aged individuals. Histopathologically, VX is diagnosed by presence of lipid-laden foam cells in papillary region of connective tissue. A 60-year-old male patient presented with a painless growth on the left buccal mucosa. On clinical examination a yellowish white exophytic lesion, measuring 11 × 7 mm in size, was found, which was cauliflower-shaped on inspection and painless on palpation. Histopathological examination revealed varying degrees of surface parakeratosis and the accumulation of numerous foam cells in the connective tissue papillae among the uniformly elongated epithelial ridges. On immunohistochemical staining, there was a neutrophilic infiltrate of the epidermis with CD68 positive xanthoma cells restricted to the papillary dermis, mixed with other chronic inflammatory cells.

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“…According to the literature, the differential diagnosis must include lesions with a papillomatous or verrucous aspect, such as papilloma, condylomata acuminatum, common (vulgar) wart, verrucous carcinoma or even epidermoid carcinoma in the initial stage 11,20 . The treatment of choice was to perform excisional biopsy of the two lesions, with excellent prognosis up to the present date.…”

Section: Collaboratorsmentioning

confidence: 99%

Verruciform xanthoma: case report

Monteiro

Furuse

Cé

et al. 2016

RGO, Rev. Gaúch. Odontol.

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Verruciform xanthoma is a rare, benign lesion, with a papillary aspect, asymptomatic, sessile, white colored, and well-demarcated, that RESUMOO xantoma verruciforme é uma lesão muito rara, benigna, com aspecto papilar, indolor, séssil, localizada, principalmente, na gengiva e mucosa alveolar, podendo ocorrer na pele e genitália. O grau de queratinização da superfície influencia na cor, variando de branca a vermelha. Histopatologicamente é caracterizado pela presença de macrófagos com citoplasma espumoso (células de xantoma) acumulados e confinados ao tecido conjuntivo papilar. Criptas invaginadas alternam-se com extensões papilares. As cristas epiteliais alongadas estendem-se para a lâmina própria em profundidade uniforme. Sua etiologia e patogênese são desconhecidas, apesar de várias hipóteses terem sido sugeridas, como trauma local ou viral. O diagnóstico diferencial pode incluir o papiloma escamoso, o carcinoma escamoso papilar e o condiloma acuminado. O tratamento é a excisão conservadora e o prognóstico é excelente. O objetivo deste trabalho foi relatar um caso clínico de xantoma verruciforme localizado na gengiva inserida mostrando seu aspecto clínico e histopatológico.Termos de indexação: Xantomatose. Diagnóstico. Patologia bucal.

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Oral Verruciform Xanthoma: A Clinicopathologic Study of 15 Cases

Abstract: Oral VXs occur more frequently in the fifth decade of life. The more commonly affected site is the gingiva. The treatment of choice for oral VXs is surgical excision. The prognosis is excellent and recurrence was not seen in this study.

Cited by 44 publications

References 22 publications

Verruciform Xanthoma-Histopathologically: A Distinct Entity

Verruciform Xanthoma-Histopathologically: A Distinct Entity

Oral verruciform xanthoma: a case report and literature review

Verruciform xanthoma: case report

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