Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation

Korantzopoulos, Panagiotis; Kolettis, Theofilos M.; Kountouris, Evaggelos; Dimitroula, Vasiliki; Karanikis, Pavlos; Pappa, Eleni; Siogas, Konstantinos; Goudevenos, John

doi:10.1016/j.ijcard.2004.12.041

Cited by 131 publications

(108 citation statements)

References 29 publications

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“…[3][4][5][6][7] It also attenuates reperfusion arrhythmia [3][4][5]7 and recurrent atrial fibrillation. 28 In this study, ascorbic acid administration diminished MDA generation and myocardial damage after VF cardiac The HypoT, AA+NormoT, and AA+HypoT groups had significantly higher neurologic function scores than the NormoT group at the sixth, 24th, 48th, and 72nd hours following ROSC. No difference was noted among the AA+NormoT, HypoT, and AA+HypoT groups.…”

Section: Discussionmentioning

confidence: 52%

Combination of Intravenous Ascorbic Acid Administration and Hypothermia After Resuscitation Improves Myocardial Function and Survival in a Ventricular Fibrillation Cardiac Arrest Model in the Rat

Tsai

Huang

Tsai

et al. 2014

Academic Emergency Medicine

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Objectives: Intravenous (IV) administration of ascorbic acid during cardiopulmonary resuscitation (CPR) was reported to facilitate defibrillation and improves survival in ventricular fibrillation (VF) cardiac arrest. We investigated whether IV administration of ascorbic acid after return of spontaneous circulation (ROSC) can improve outcomes in VF cardiac arrest in a rat model and its interaction with therapeutic hypothermia.Methods: Ventricular fibrillation-induced cardiac arrest followed by CPR and defibrillation was performed in male Wistar rats. After ROSC, the animals were equally randomized to the normothermia (NormoT), hypothermia (HypoT), ascorbic acid (AA+NormoT), and ascorbic acid plus hypothermia (AA+HypoT) groups. The AA+NormoT and AA+HypoT groups received IV ascorbic acid (100 mg/kg). In the HypoT and AA+HypoT groups, therapeutic hypothermia was maintained at 32°C for 2 hours.Results: There were 12 rats in each group. Within 4 hours after ROSC, the HypoT, AA+NormoT, and AA+HypoT groups had significantly lower myocardial lipid peroxidation than the NormoT group. Within 4 hours following ROSC, the AA+NormoT group had a significantly better systolic function (dp/dt 40 ) than the NormoT group (6887.9 mm Hg/sec, SD AE 1049.7 mm Hg/sec vs. 5953.6 mm Hg/sec, SD AE 1161.9 mm Hg/sec; p < 0.05). The AA+HypoT group also showed a significantly better diastolic function (-dp/dt max ) than the HypoT group (dp/dt 40 : 8524.8, SD AE 1166.7 mm Hg/sec vs. 7399.8 mm Hg/sec, SD AE 1114.5 mmHg/sec; dp/dt max : -8183.4 mm Hg/sec, SD AE 1359.0 mm Hg/sec vs. -6573.7 mm Hg/sec, SD AE 1110.9 mm Hg/sec; p < 0.05) at the fourth hour following ROSC. Also at 4 hours, there was less myocytolysis in the HypoT, AA+NormoT, and AA+HypoT groups than the NormoT group. The HypoT, AA+NormoT, and AA+HypoT groups had significantly better survival rates and neurologic outcomes than the NormoT group. Compared with only five surviving animals in the NormoT group, there were nine, eight, and 10 in the HypoT, AA+NormoT, and AA+HypoT groups, respectively, with good neurologic outcomes at 72 hours.Conclusions: Intravenous ascorbic acid administration after ROSC in normothermia may mitigate myocardial damage and improve systolic function, survival rate, and neurologic outcomes in VF cardiac arrest of rat. Combination of ascorbic acid and hypothermia showed an additive effect in improving both systolic and diastolic functions after ROSC.ACADEMIC EMERGENCY MEDICINE 2014; 21:257-265

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Section: Discussionmentioning

confidence: 52%

Combination of Intravenous Ascorbic Acid Administration and Hypothermia After Resuscitation Improves Myocardial Function and Survival in a Ventricular Fibrillation Cardiac Arrest Model in the Rat

Tsai

Huang

Tsai

et al. 2014

Academic Emergency Medicine

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“…Korantzopoulos et al [21] prospectively studied 44 patients following successful electrical cardioversion of persistent AF. The patients randomized into Vitamin C group and control group.…”

Section: Vitamin C and Ementioning

confidence: 99%

Antioxidant Therapies in the Prevention and Treatment of Atrial Fibrillation

Liu¹,

Korantzopoulos²,

Li³

2013

Atrial Fibrillation - Mechanisms and Treatment

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“…In a cohort study, LA diameter independently predicted cardiovascular events (nonfatal stroke, coronary heart disease, congestive heart failure, and fatal cardiovascular disease) after adjustment for established clinical, echocardiographic, and inflammatory risk factors [23]. Thus, LA dilatation identifies individuals at heightened risk who warrant aggressive risk factor modification.…”

Section: Discussionmentioning

confidence: 99%

Left Atrial Enlargement Correlates with Inflammation and Oxidative Stress in Patients at High Risk for Atrial Fibrillation

Bloom¹,

Shukrullah²,

Jang³

et al. 2010

J Clinic Experiment Cardiol

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Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation

Cited by 131 publications

References 29 publications

Combination of Intravenous Ascorbic Acid Administration and Hypothermia After Resuscitation Improves Myocardial Function and Survival in a Ventricular Fibrillation Cardiac Arrest Model in the Rat

Combination of Intravenous Ascorbic Acid Administration and Hypothermia After Resuscitation Improves Myocardial Function and Survival in a Ventricular Fibrillation Cardiac Arrest Model in the Rat

Antioxidant Therapies in the Prevention and Treatment of Atrial Fibrillation

Left Atrial Enlargement Correlates with Inflammation and Oxidative Stress in Patients at High Risk for Atrial Fibrillation

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