Oral water ingestion in the treatment of shock patients: a prospective randomized study

Guinot, Pierre-Grégoire; Nguyen, Maxime; Duclos, Valerian; Soudry-Faure, Agnès; Bouhemad, Bélaïd

doi:10.1007/s00134-020-06215-y

Cited by 3 publications

(3 citation statements)

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“…2018-A03368-47, NCT03951519). This study is a second part of an investigation aimed at describing the value of oral water in shock patients ( 9 ). All patients or their next of kin received written information about the study and gave their written consent to participate.…”

Section: Methodsmentioning

confidence: 99%

“…While the cardiovascular effect of volume expansion by saline has already been investigated in patients admitted to the intensive care unit (ICU), the cardiovascular effects of oral water is unknown. Only one before/after study have demonstrated an increase of stroke volume ( 9 ). Cardiologic studies have demonstrated that in non-shocked patients, oral water can change CO and blood pressure through various physiological effects: increase in blood volume, recruitment of splanchnic blood volume, activation of vasomotor tone, or change in heart rate ( 9 – 12 ).…”

Section: Introductionmentioning

confidence: 99%

“…Only one before/after study have demonstrated an increase of stroke volume ( 9 ). Cardiologic studies have demonstrated that in non-shocked patients, oral water can change CO and blood pressure through various physiological effects: increase in blood volume, recruitment of splanchnic blood volume, activation of vasomotor tone, or change in heart rate ( 9 – 12 ). Oral water could be used to modulate orthostatic arterial hypotension.…”

Section: Introductionmentioning

confidence: 99%

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Oral Water Has Cardiovascular Effects Up to 60 min in Shock Patients

Guinot

Nguyen

Duclos³

et al. 2021

Front. Cardiovasc. Med.

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Aim: Little is known about the cardiovascular effects of oral water intake in shock patients. This study was designed to assess the effect of oral water on stroke volume and blood pressure during a 1-h time period.Method and Results: This open-label, randomized clinical trial included patients admitted to intensive care with acute circulatory failure. Three ICU units at the anesthesia and critical care department of the Dijon Bourgogne University Hospital. Patients were randomized 1:1 to an intervention or standard care group. The intervention group received 500 ml of oral water while the standard care group received intravenous administration of 500 ml of physiological saline solution. Baseline SV did not differ between the two groups (36 ml [28;51] vs. 38 ml [30;51], p = 0.952). The number of patients who were fluid responders did not differ between the two groups [n = 19 (76%) vs. n = 18 (72%), p = 1]. The median change in stroke volume during the three time points did not differ between the two groups (p < 0.05). In the intervention group, blood pressure increased up to 60 min. In the control group, blood pressure quickly increased at the end of fluid expansion, then returned close to baseline value at 60 min.Conclusion: Shock patients who were administered oral water experienced improvements in blood pressure and blood flow up to 60 min when compared with patients who received intravenous saline solution. Further studies are warranted to confirm these effects.Clinical Trial Registration:www.clinicaltrials.gov, identifier: NCT03951519.

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Section: Methodsmentioning

confidence: 99%