Oral Yeast Colonization and Fungal Infections in Peritoneal Dialysis Patients: A Pilot Study

Simões-Silva, Liliana; Silva, Sara; Santos-Araújo, Carla; Sousa, Joana; Pestana, Manuel; Araújo, Ricardo; Soares-Silva, Isabel

doi:10.1155/2017/4846363

Cited by 6 publications

(3 citation statements)

References 28 publications

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“…In conclusion, the presence of UTs, the alterations of metabolic pathways, high levels of ammonia and urea and high pH, are involved in the alteration of the oral environment as well as of the gut environment [ 146 , 209 ].…”

Section: The Possible Link Between Oral Dysbiosis and Gut Dysbiosis A...mentioning

confidence: 99%

Saliva as Biomarker for Oral and Chronic Degenerative Non-Communicable Diseases

et al. 2023

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Saliva is a very complex fluid and it is essential to maintain several physiological processes and functions, including oral health, taste, digestion and immunological defenses. Saliva composition and the oral microbiome can be influenced by several factors, like diet and smoking habits, and their alteration can represent an important access point for pathogens and, thus, for systemic illness onset. In this review, we explore the potentiality of saliva as a new tool for the early detection of some pathological conditions, such as oral diseases, chronic degenerative non-communicable diseases, among these chronic kidney disease (CKD). We also examined the possible correlation between oral and systemic diseases and oral and gut microbiota dysbiosis. In particular, we deeply analyzed the relationship between oral diseases and CKD. In this context, some salivary parameters can represent a new device to detect either oral or systemic pathologies. Moreover, the positive modulation of oral and gut microbiota induced by prebiotics, postbiotics, or symbiotics could represent a new possible adjuvant therapy in the clinical management of oral diseases and CKD.

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Section: The Possible Link Between Oral Dysbiosis and Gut Dysbiosis A...mentioning

confidence: 99%

Saliva as Biomarker for Oral and Chronic Degenerative Non-Communicable Diseases

et al. 2023

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“…Patients who suffer from kidneys fail are exposed to 1800-36000 liter of water during the dialysis in each year (1) .Patients with end-stage renal disease (ESRD) widely used Peritoneal dialysis (PD) and renal replacement therapy at home (2). Dialysis equipment contaminated with high levels of microorganisms, several natural inhabitants of water and soil found as saprophytic fungi act as parasite (pathogens) in immunocomptent host.…”

Section: ‫نمو‬ ‫تقييم‬ ‫مستشفى‬ ‫فى‬ ‫والصفاقية‬ ‫الدموية‬ ‫الديلزة‬ mentioning

confidence: 99%

Assessment of Fungal Growth at Hemodialysis and Peritoneal Dialysis Unit in Hawler Teaching Hospital

Al-Barzinji¹

2020

J.Edu.Sci.

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Dialysis is used when the patient's kidneys can no longer perform their functions normally; it is a treatment that performs the functions of natural kidneys. Most patients begin dialysis when their kidneys have lost 85-90% of their ability to work naturally and they have to depend on dialysis for the rest of their lives, is called end-stage renal disease (ESRD). Infection in patients with end stage renal disease (ESRD) is usually treated with hemodialysis (HD) or peritoneal dialysis (PD). End stage renal disease a major cause of morbidity and mortality, in order to assess the fungal growth at hemodialysis and peritoneal dialysis unit a descriptive study was conducted at hemodialysis and peritoneal dialysis units in Hawler teaching hospital, from 15 th of January to the end of May 2017;the study also includes the access sites and peritoneal catheter site. Factors that affected the access site among dialysis patient in the hospital. Sample of 63 patients, who were attending to the dialysis unit at time of the data collection, had been taken; in addition to that swab samples had been gathered from access site and peritoneal catheter site. The results of the study revealed that the fungal growth was positive at dialysis access sites, where the total percentage was 84.1% and that of peritoneal catheter site was 15.85%. In these unites, different types of filamentous fungi and yeasts had been successfully isolated.

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“…The decrease in kidney function leads to the accumulation of substances in the body that in normal conditions would be eliminated in the urine ( Lisowska-Myjak, 2014 ). These substances, known as uremic toxins, build up inside the organism and cause alterations in various body sites, including the oral cavity, with higher levels of urea, ammonia and pH being commonly detected in the saliva of CKD patients ( Gupta et al, 2015 ; Simões-Silva et al, 2017 ). These changes are thought to be major selective factors responsible for altering the oral microbiome, which has shown significant association with CKD status ( Simões-Silva et al, 2017 , 2018 ; Hu et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Oral Enterobacteriaceae Prevalence and Resistance Profile in Chronic Kidney Disease Patients Undergoing Peritoneal Dialysis

et al. 2021

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Chronic Kidney Disease (CKD) is a growing public-health concern worldwide. Patients exhibit compromised immunity and are more prone to infection than other populations. Therefore, oral colonization by clinically relevant members of the Enterobacteriaceae family, major agents of both nosocomial and dialysis-associated infections with frequent prevalence of antibiotic resistances, may constitute a serious risk. Thus, this study aimed to assess the occurrence of clinically relevant enterobacteria and their antibiotic resistance profiles in the oral cavity of CKD patients undergoing peritoneal dialysis (CKD-PD) and compare it to healthy controls. Saliva samples from all the participants were cultured on MacConkey Agar and evaluated regarding the levels of urea, ammonia, and pH. Bacterial isolates were identified and characterized for antibiotic resistance phenotype and genotype. The results showed that CKD-PD patients exhibited significantly higher salivary pH, urea, and ammonia levels than controls, that was accompanied by higher prevalence and diversity of oral enterobacteria. Out of all the species isolated, only the prevalence of Raoultella ornithinolytica varied significantly between groups, colonizing the oral cavity of approximately 30% of CKD-PD patients while absent from controls. Antibiotic resistance phenotyping revealed mostly putative intrinsic resistance phenotypes (to amoxicillin, ticarcillin, and cephalothin), and resistance to sulfamethoxazole (~43% of isolates) and streptomycin (~17%). However, all isolates were resistant to at least one of the antibiotics tested and multidrug resistance isolates were only found in CKD-PD group (31,6%). Mobile genetic elements and resistance genes were detected in isolates of the species Raoultella ornithinolytica, Klebsiella pneumoniae, Klebsiella oxytoca, Escherichia coli, and Enterobacter asburiae, mostly originated from CKD-PD patients. PD-related infection history revealed that Enterobacteriaceae were responsible for ~8% of peritonitis and ~ 16% of exit-site infections episodes in CKD-PD patients, although no association was found to oral enterobacteria colonization at the time of sampling. The results suggest that the CKD-induced alterations of the oral milieu might promote a dysbiosis of the commensal oral microbiome, namely the proliferation of clinically relevant Enterobacteriaceae potentially harboring acquired antibiotic resistance genes. This study highlights the importance of the oral cavity as a reservoir for pathobionts and antibiotic resistances in CKD patients undergoing peritoneal dialysis.

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Oral Yeast Colonization and Fungal Infections in Peritoneal Dialysis Patients: A Pilot Study

Cited by 6 publications

References 28 publications

Saliva as Biomarker for Oral and Chronic Degenerative Non-Communicable Diseases

Saliva as Biomarker for Oral and Chronic Degenerative Non-Communicable Diseases

Assessment of Fungal Growth at Hemodialysis and Peritoneal Dialysis Unit in Hawler Teaching Hospital

Characterization of Oral Enterobacteriaceae Prevalence and Resistance Profile in Chronic Kidney Disease Patients Undergoing Peritoneal Dialysis

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