Oral zinc sulphate in the treatment of recalcitrant viral warts: randomized placebo-controlled clinical trial

Abstract

We conclude that zinc sulphate at a dose of 10 mg kg(-1) daily seems to be a highly efficacious therapeutic option for recalcitrant viral warts and proved to be safe with few adverse effects.

Role of oral zinc sulphate in warts-a placebo controlled,single-blinded study

“…Zinc has been previously used as an immunomodulator in a number of dermatological diseases such as erythema nodosum leprosum and dissecting cellulitis of scalp [13]. Al-Gurari FT et al used oral zinc sulphate at a dosage of 10mg/kg for a total period of two months in the treatment of viral warts with a cure rate of 87% [14]. The present study was done to find out the efficacy of oral zinc sulphate at lower doses and for a shorter duration in order to minimize side effects and to improve compliance respectively.…”

British Association of Dermatologists' guidelines for the management of cutaneous warts 2014

“…150 A poor-quality single-blinded RCT showed 87% response in the zinc sulfate patient group, compared with no response in the placebo group, but all patients had a low serum zinc level pretreatment. 151 Yaghoobi et al,…”

Effect of Oral Zinc Sulfate on Local Inflammatory Cytokines Level in Iraqi Women Infected With Human Papillomavirus (HPV)

“…Moreover, the effect of zinc on the common cold may be due to the increased zinc concentrations in the nasal mucosa, which may alter the conformation of the binding site between the virus and ICAM-1 [13]. Al-Gurari, et al [14], used oral zinc sulfate for a total period of two months in the treatment of viral warts with a cure rate of 87%. Also, other study showed that patients who received oral zinc sulfate, 60.97% showed a complete response at the end of six weeks in comparison to 6.45% partial response in the placebo group [15].…”