Orally administered aqueous extract of Inonotus obliquus ameliorates acute inflammation in dextran sulfate sodium (DSS)-induced colitis in mice

Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity by down-regulation of the β-catenin pathway in colorectal cancer

“…We previously demonstrated that an aqueous extract from Chaga mushroom exerted antiproliferative and anti-inflammatory activities in colon cancer cells by down-regulating β-catenin (Mishra et al, 2012). To investigate the effect of ergosterol peroxide on the β-catenin pathway in CRC cells, cells were treated with ergosterol peroxide and Western blotting was performed.…”

“…In addition, the antitumor effect of three compounds (3β-hydroxy-lanosta-8,24-dien-21-al, inotodiol, and lanosterol) from Inonotus obliquus extracts were reported against Sarcoma-180-cell-bearing mice (Chung et al, 2010). We previously demonstrated that an aqueous extract of IOAE down-regulated β-catenin and NF-κB signaling, which exerted anti-proliferative and anti-inflammatory activities in colon cancer cells (Mishra et al, 2012).…”

Wheat germ agglutinin anchored chitosan microspheres of reduced brominated derivative of noscapine ameliorated acute inflammation in experimental colitis

“…Colitis was induced by continuous administration of 3% DSS for 7 days [22]. Previous studies indicated that budesonide, a slightly lipophilic, anti-inflammatory drug was encased in Eudragit S100 coated chitosan-Ca-alginate microparticles that exhibited ∼1.5-fold superior anti-inflammatory activity in experimental colitis as compared to budenoside suspension [51].…”

“…Group A received no dextran sodium sulfate (DSS) and received only drinking water and thus designated as normal control group. Continuation to this, group B was administered 3% DSS in drinking water for 7 days [22] to induce acute colitis in mice followed by oral intake of 500 L of PBS (pH ∼ 7.4) for next 7 days. Further, groups C, D and E received 3% DSS for 7 days followed by oral treatment with 100 mg/kg of Red-Br-Nos suspension, CTS-MS-Red-Br-Nos (∼100 mg/kg of Red-Br-Nos) and WGA-CTS-MS-Red-Br-Nos (∼100 mg/kg of Red-Br-Nos), respectively, for next 7 days.…”

“…In addition, various characterization parameters like particle size, zeta-potential, encapsulation efficiency, bioadhesive property and in vitro drug release were examined using analytical and spectral techniques. The in vivo study was conducted to analyze the anti-inflammatory activity of WGA-CTS-MS-Red-Br-Nos, CTS-MSRed-Br-Nos and Red-Br-Nos suspension in dextran sodium sulfate (DSS) induced experimental colitis model [22].…”