Orally Administered Benidipine and Manidipine Prevent Ischemia - Reperfusion Injury in the Rat Heart

Sakaguchi, Masanori; Shibata, Toshihiko; Hattori, Koji; Hirai, Hidekazu; Hosono, Mitsuharu; Aoyama, Takanobu; Ikuta, Takeshi; Bito, Yasuyuki; Suehiro, Shigefumi

doi:10.1253/circj.68.241

Cited by 10 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although there is currently no clear consensus of what the target HbA1C should be in the diabetic hemodialysis population, tight glycemic control is believed to be beneficial. Recently, Masanori et al [11] reported better glycemic control in diabetic dialysis patients by adding mitiglinide before meals. Efficacy was determined by monitoring plasma glucose, HbA1c and glycated albumin levels.…”

Section: Discussionmentioning

confidence: 99%

Correlation between glycated hemoglobin and mean plasma glucose in hemodialysis patients

et al. 2010

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Correlation between glycated hemoglobin and mean plasma glucose in hemodialysis patients

et al. 2010

View full text Add to dashboard Cite

show abstract

“…It was reported that the other members of this group of drugs, amlodipine, nifedipine and benidipine have cardioprotective effects against myocardial ischaemia–reperfusion injury via NO-dependent mechanisms 16,17,24. Therefore the enhancing effects of NO may not be attributable to the mebudipine, although its capability to increase NO levels due to calcium channel antagonists may be different.…”

Section: Discussionmentioning

confidence: 99%

“…Endothelial function is important for the preservation of the organ function against ischaemic or hypertensive stress 14,15. Many studies have reported that Ca 2+ channel blockers such as amlodipine, nifedipine and benidipine increase NO production 16,17…”

Section: Introductionmentioning

confidence: 99%

The effect of mebudipine on cardiac function and activity of the myocardial nitric oxide system in ischaemia-reperfusion injury in rats

Ghyasi¹,

Mohammadi²,

Badalzadeh³

et al. 2011

Cardiovascular Journal of Africa

View full text Add to dashboard Cite

ObjectivesPrevious studies have suggested that failure of the synthesis of nitric oxide is involved in the pathophysiology of myocardial ischaemia–reperfusion injury. In this study, we investigated the effect of mebudipine, a new dihydropyridine calcium channel blocker, on cardiac function and activity of the myocardial nitric oxide system in ischaemia–reperfusion injury in isolated rat hearts.MethodsForty male Wistar rats (250–300 g) were divided into four groups (n = 10): sham, control, vehicle and drug groups. The animals were anesthetised with sodium pentobarbital (6 mg/kg intraperitoneal). The hearts were quickly removed, mounted on a Longendorff apparatus and perfused with Krebs-Henseleit solution under constant pressure at 37°C. After 20 min stabilisation period, the ischaemic groups received 30 min global ischaemia and 120 min reperfusion. For the drug and vehicle groups, before ischaemia the hearts were perfused with mebudipine (10-3 µM) or ethanol-enriched solution (0.01%) for 25 min, respectively. Myocardial function, and creatine kinase, lactate dehydogenase and total nitric oxide metabolite (nitrite and nitrate) levels were analysed.ResultsCardiac functions had recovered significantly in the mebudipine group (p < 0.01). Furthermore, mebudipine remarkably reduced the levels of lactate dehydogenase and creatine kinase in the coronary effluent and increased myocardial nitric oxide metabolite levels compared with the control group.ConclusionOur results indicate that mebudipine reduced the intensity of myocardial ischaemia–reperfusion injury, and that activation of the myocardial nitric oxide system played an important role in this regard.

show abstract

Combined simvastatin–manidipine protect against ischemia–reperfusion injury in isolated hearts from normocholesterolemic rats

Rossoni

Manfredi

Civelli

et al. 2008

European Journal of Pharmacology

View full text Add to dashboard Cite

Orally Administered Benidipine and Manidipine Prevent Ischemia - Reperfusion Injury in the Rat Heart

Abstract: Orally administered benidipine and manidipine exerted significant cardioprotective effects against ischemia - reperfusion injury.

Cited by 10 publications

References 26 publications

Correlation between glycated hemoglobin and mean plasma glucose in hemodialysis patients

Correlation between glycated hemoglobin and mean plasma glucose in hemodialysis patients

The effect of mebudipine on cardiac function and activity of the myocardial nitric oxide system in ischaemia-reperfusion injury in rats

Combined simvastatin–manidipine protect against ischemia–reperfusion injury in isolated hearts from normocholesterolemic rats

Contact Info

Product

Resources

About