Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis

Liposomalization of Lactoferrin Enhanced It's Anti-inflammatory Effects via Oral Administration

“…36,37) It has also been reported that oral administration of bLF to mice increased the secretion of anti-bLF IgA and IgG in the intestinal fluid but made no difference in the serum, and it is suggested that bLF could act as an immunostimulating factor of the mucosal immune system. 38) On the other hand, it has been demonstrated that a portion of bLF is transported into blood circulation through the intestine 32,33) as previously noted.…”

Intracellular Retention and Subsequent Release of Bovine Milk Lactoferrin Taken Up by Human Enterocyte-Like Cell Lines, Caco-2, C2BBe1 and HT-29

“…4,5) Orally administered or ingested bovine milk LF has recently been suggested to affect iron absorption, mucosal and systemic immunity, and lipid absorption and metabolism in both infants and adults of animals and humans. [6][7][8][9][10][11] Despite many phenomenological studies on the various physiological functions of orally administered LF, the intestinal absorption mechanism and subsequent in vivo kinetics of LF have not been well investigated.…”

The Role of Interleukin-1 and Associated Cytokines in Gastric Carcinogenesis

“…Имеются данные об экспрессии ИЛ-18 опухолевыми клетками, обладающими низкой пролиферативной активностью и медленным ростом, что объясняется индуцированной продукцией ИФН-γ [30]. Установлено, что индукция синтеза ИЛ-18 в плазме крови приводит к блокированию роста и пролиферации эндоте-лиоцитов, угнетению ангиогенеза [32]. По данным R. Cao и соавт., ИЛ-18 прямо ингибирует индуцированную фактором роста фибробластов пролиферацию эндоте-лиоцитов, останавливает формирование новых сосудов, регрессирует растущие сосуды в курином эмбрионе [33].…”