Orally Administered Drug Delivery Systems to the Colon

Milabuer, Mirela Nadler; Kam, Yossi; Rubinstein, Abraham

doi:10.1002/9780470640487.ch14

Cited by 3 publications

(1 citation statement)

References 175 publications

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“…The transverse colon exhibits a pH of 7.4, descending colon, pH 7.5, sigmoidal colon, pH 7.4, and rectum, pH 7.2. The shallow pH gradient between the small intestine and the colon does not allow the design of colonic delivery drug carriers based on pH changes (Milabuer et al, 2010).…”

Section: Large Intestinementioning

confidence: 99%

Encapsulation of Folic Acid in Mesoporous Silica Supports: A Nutritional and Technological Approach

Pérez‐Esteve¹

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En la segona part, s'ha avaluat la influència de l'addició de diferents suports d'òxid de silici a dos matrius alimentàries, gels de gelatina i iogurts. Esta aproximació tecnològica ha permés conéixer que la capacitat d'aquests sistemes intel•ligents per alliberar controladament àcid fòlic durant un procés de digestió in vitro es manté fins i tot després de ser incorporats en iogurts batuts. D'altra banda, s'ha comprovat que l'efecte de les matrius sobre les propietats físiques dels gels, és dependent tant de la grandària de les partícules, com de la seua funcionalització i concentració. Per últim, s'ha comprovat que a causa de l'optimització del carregat d'àcid fòlic assolida en la primera part de la tesi, es pot aconseguir una fortificació d'un iogurt amb el 100% de la quantitat diària recomanada d'àcid fòlic amb una quantitat tan baixa del sistema que ni les propietats físico-químiques del iogurt, ni la viabilitat bacteriana se'n veuen compromeses.En resum, es pot concluir que en la present tesi s'ha abordat d'una manera global l'encapsulació d'àcid fòlic en matrius poroses d'òxid de silici per a ser utilitzades en aplicacions nutricionals i alimentàries, que inclouen estudis d'optimització de carregat, estudis d'alliberament en funció del pH, digestions in vitro, estudis d'estabilitat de les matrius utilitzades, estudis de biocompatibilitat, així com estudis de la influència de l'addició d'aquests sistemes en matrius alimentàries. Els resultats obtinguts han posat de manifest de forma positiva que els sistemes intel•ligents d'àcid fòlic que s'han desenvolupat obrin una porta a una nova manera de fortificar els aliments sense comprometre les seues característiques físico-químiques.

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Section: Large Intestinementioning

confidence: 99%

Encapsulation of Folic Acid in Mesoporous Silica Supports: A Nutritional and Technological Approach

Pérez‐Esteve¹

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Mesoporous Silica‐Based Supports for the Controlled and Targeted Release of Bioactive Molecules in the Gastrointestinal Tract

Pérez‐Esteve

Ruiz-Rico

Martínez‐Máñez

et al. 2015

Journal of Food Science

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Mesoporous silica particles (MSPs) have attracted increasing interest as supports in the design of controlled delivery materials. Besides their excellent properties as loading supports (that is, large surface area and pore volume), the modification of their external surface with molecular/supramolecular ensembles allows the design of gated MSPs. Delivery systems based on gated MSPs show "zero delivery" until an adequate stimulus is present and triggers gate opening and the cargo is released. Encapsulation of bioactive molecules in gated MSPs may improve biological stability, facilitate component handling, mask unpleasant sensorial properties, and modulate the bioaccessibility of target molecules along the gastrointestinal tract. These properties make gated MSPs excellent candidates for encapsulating bioactive molecules and their subsequent utilization in the formulation of functional foods. This text highlights the most significant endogenous triggering stimuli that might be applied to design these site-specific delivery systems, as well as the strategies to develop them. Given the novelty of using MSPs in the food sector, the benefits and current potential limitations of employing MSPs in human food have been identified and discussed.

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Formulation and Evaluation of colon targeted drug Delivery of Diloxanide furoate Tablets using pH Dependent Polymers

Krosuri

Ravikumar

S.N.

et al. 2021

RJPT

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Diloxanide Furoate is a Dichloroacetamide derivative utilized for the treatment of various protozoal infections like amoebiasis. Colon targeted tablets were designed using pH sensitive polymers like Eudragit S100, Eudragit L 100,Cellulose acetate phthallate at different concentrations. All the matrix,compression coated formulations showed the desired physicochemical properties as per the official limits. The drug release studies were performed according to the USP paddle method by using 0.1N HCL for 2 hours, pH 7.4 phosphate buffer for 3 hours and pH 6.8 phosphate buffer upto 18 hours. A better controlled drug release was shown for Eudragit L 100. Based on the comparative drug release studies among different Formulations F9 with Eudragit L 100 polymer showed better control drug release. The release kinetics for the Optimised Formulation F9 was calculated and “r2” value was more for Zero order kinetics i.e.,0.970 indicating that the formulation doesnot depend upon its concentration and from the Korsmeyer peppas model the diffusion exponent value “n” is > 1 indicating that it follows super case II transport mechanism. The accelerated stability studies conducted for optimised formulation F9 for 3 months have no significant variation.

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Orally Administered Drug Delivery Systems to the Colon

Cited by 3 publications

References 175 publications

Encapsulation of Folic Acid in Mesoporous Silica Supports: A Nutritional and Technological Approach

Encapsulation of Folic Acid in Mesoporous Silica Supports: A Nutritional and Technological Approach

Mesoporous Silica‐Based Supports for the Controlled and Targeted Release of Bioactive Molecules in the Gastrointestinal Tract

Formulation and Evaluation of colon targeted drug Delivery of Diloxanide furoate Tablets using pH Dependent Polymers

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