Orally administered HSV-specific transfer factor (TF) prevents genital or labial herpes relapses

Pizza, G; Viza, D.; C, De Vinci; Palareti, Aldopaolo; Cuzzocrea, D; Fornarola,; Baricordi, Roberto

doi:10.1007/bf02628659

Cited by 21 publications

(13 citation statements)

References 36 publications

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“…showing antiviral, antibacterial, antitumor, or immunoregulatory activity. PRPs have been experimentally shown to provide immunity to herpes viruses [1,2], vesicular stomatitis virus [3], EpsteinBar virus [4], measles [5], and HIV (human immunodeficiency virus) [6]. Of the many peptide families that can be isolated from all classes of animals, the short proline-rich antibacterial peptides are of particular interest.…”

Section: The Proline-rich Peptide Familymentioning

confidence: 99%

Colostral Proline-Rich Polypeptides – Immunoregulatory Properties and Prospects of Therapeutic Use in Alzheimers Disease

Janusz¹,

Zabłocka

2010

CAR

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A proline-rich polypeptide complex (PRP), subsequently called Colostrinin(CLN), was first isolated from ovine colostrum, was shown to possess immunoregulatory properties, including effects on the maturation and differentiation of murine thymocytes and humoral and cellular immune responses, both in vivo and in vitro. PRP seems to restore balance in cellular immune functions and is not species specific. PRP is a complex of peptides of molecular masses ranging from 500 to 3000 Da. The polypeptide contains 25% proline and 40% hydrophobic amino acids. PRP shows a regulatory activity in cytokine (IFN, TNF-alpha, IL-6, IL-10) induction and possesses the ability to inhibit the overproduction of oxygen reactive species and nitric oxide. Besides its immunoregulatory activity, PRP also showed psychotropic properties, improving cognitive activity and behavior of old rats, humans, and chickens. The properties of PRP prompted the authors to propose the complex for the treatment neurodegenerative disorders. Beneficial effects of PRP/Colostrinin were shown for the first time in double-blind placebo-controlled trials and long-term open-label studies. The results were confirmed in multicenter clinical trials. A very important property of PRP/Colostrinin is the prevention of Abeta aggregation and the disruption of already existing aggregates. The same properties were expressed by one of PRP's components, a nonapeptide (NP). Moreover, PRP modulates neurite outgrowth, suppresses uncontrolled activation of cells, reduces 4-HNE-mediated cellular damage, and modulates expression in cellular redox regulation, cell proliferation, and differentiation. Its biological response modifying activity can play an important role in its use in the treatment of Alzheimer's disease.

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Section: The Proline-rich Peptide Familymentioning

confidence: 99%

Colostral Proline-Rich Polypeptides – Immunoregulatory Properties and Prospects of Therapeutic Use in Alzheimers Disease

Janusz¹,

Zabłocka

2010

CAR

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“…One of the unique features of STF is that it does not have immunogenicity and genus specificity but the STF prepared by one genus of animals like goat, rabbit, dog, and so forth has the ability of transferring the immunological activity to other genera of animals without causing hypersensitivity. Currently, several STFs have been successfully developed; mainly for herpes simplex virus type 1 (HSV-1) [7], Epstein-Barr virus [8], and Staphylococcus aureus antigens [9]. Also, STFs have been used in therapy of many diseases, for example, lyme, candidiasis, and herpes simplex [10–14].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Characterization, and Determination of Immunological Activities of Transfer Factor Specific to Human Sperm Antigen

Zhou

Chen

Zhao-hong

et al. 2013

BioMed Research International

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Objective. The objective of this study was to prepare, characterize, and determine immunological activities of specific transfer factor (STF) specific to human sperm antigen (HSA) for the preparation of antisperm contraceptive vaccine that can be used as an immunocontraceptive. Methods. HSA-STF was prepared using the spleens of rabbits vaccinated with HSA. The specific immunological activities were examined by lymphocyte proliferation test (LPT), leukocyte adhesion inhibition test (LAIT), and by determining the concentrations of IL-4, γ-IFN, and IL-21. HSA-STF was a helveolous substance, having a pH value of 7.0 ± 0.4 and UV absorption maxima at 258 ± 6 nm. It contained seventeen amino acids; glycine and glutamic acids were the highest in terms of concentrations (38.8 μg/mL and 36.3 μg/mL, resp.). Results. The concentration of polypeptide was 2.34 ± 0.31 mg/mL, and ribose was 0.717 ± 0.043 mg/mL. The stimulation index for lymphocyte proliferation test was 1.84, and the leukocyte adhesion inhibition rate was 37.7%. There was a statistically significant difference between the cultural lymphocytes with HSA-STF and non-HSA-STF for γ-IFN and IL-21 (P < 0.05), but there was no statistical significance for IL-4 (P > 0.05). Conclusion. HSA-STF was prepared and characterized successfully. It had immunological activity which could transfer the immune response specific to HSA and prove to be a potential candidate for the development of male immunocontraceptive agents.

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“…Han demostrado ser efectivos en corregir la inmunidad celular defi ciente en pacientes con infecciones oportunistas tales como coccidioidomicosis y herpes simple, y en proveer inmunidad contra varicela Zoster en pacientes con leucemia aguda. 8,11,25,26,27,28 Kirkpatrick et al desarrollaron un proceso de purifi cación de factores de transferencia específi cos con homogeneidad aparente, lo que per-Cuadro 4. Estado inmunológico y nutricional antes y después del inicio de tratamiento con extractos dializados de leucocitos en 150 pacientes pediátricos con inmunodefi ciencia celular mitió separar los factores de transferencia individuales de las mezclas que contienen varios de ellos y así demostrar su especifi cidad antigénica.…”

Section: Discussionunclassified

Extractos dializados de leucocitos para el tratamiento de infecciones recurrentes y severas en pacientes pediátricos con inmunodeficiencia celular: 15 años de experiencia

Ayala

González

Palacios

et al. 2019

RAM

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Antecedentes: Los extractos dializados de leucocitos (EDL) han sido utilizados en el tratamiento de diversos defectos de la inmunidad celular.Objetivo: Revisar la experiencia en el uso de EDL para tratar infecciones recurrentes o severas en niños con inmunodeficiencia celular adquirida no debida a virus de la inmunodeficiencia oportuna.Métodos: Se revisaron expedientes de niños tratados con EDL humano o bovino entre 1986 y 2000, por infecciones recurrentes o severas sin respuesta a antimicrobianos y con déficit en la respuesta inmune celular. La dosis se ajustó por el porcentaje de poblaciones de linfocitos T. En el seguimiento a cinco años, la respuesta inmune se evaluó por subpoblaciones de linfocitos, intradermorreacción e inhibición de la migración de leucocitos (LIF) a PPD, coccidioidina, varidasa y candidina.Resultados: 150 niños recibieron EDL, edad 7.0 ± 5.9 años. Las indicaciones más frecuentes incluyeron infección respiratoria superior (71 %), respiratoria inferior (43 %), gastrointestinal (15 %), urinaria (15 %), neuroinfección (4 %) y coccidioidomicosis (3 %). Se incrementaron los linfocitos T, el LIF a PPD y varidasa (> 20 %), así como la induración en pruebas de intradermorreacción (p < 0.001). Se resolvieron las infecciones que se presentaron (4 %). No se reportaron efectos adversos.Conclusiones: El uso de EDL mejoró los parámetros inmunológicos y la evolución clínica en niños con déficit inmune celular.

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Orally administered HSV-specific transfer factor (TF) prevents genital or labial herpes relapses

Cited by 21 publications

References 36 publications

Colostral Proline-Rich Polypeptides – Immunoregulatory Properties and Prospects of Therapeutic Use in Alzheimers Disease

Colostral Proline-Rich Polypeptides – Immunoregulatory Properties and Prospects of Therapeutic Use in Alzheimers Disease

Preparation, Characterization, and Determination of Immunological Activities of Transfer Factor Specific to Human Sperm Antigen

Extractos dializados de leucocitos para el tratamiento de infecciones recurrentes y severas en pacientes pediátricos con inmunodeficiencia celular: 15 años de experiencia

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