Orally administered Kampo medicine, Juzen-taiho-to, ameliorates anemia during interferon plus ribavirin therapy in patients with chronic hepatitis C

Y, Sho; Fujisaki, Kunio; Sakashita, Hironori; Yamaguchi, Koichi; Tahara, Kenji; Kubozono, Osamu; Ido, Akio; Tsubouchi, Hirohito

doi:10.1007/s00535-004-1472-0

Cited by 16 publications

(12 citation statements)

References 5 publications

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“…It has also shown effectiveness in treating various symptoms and restoring strength in elderly people and has proven suitable for long-term administration [12]. Some clinical reports on JTT have shown hematopoiesis and anemia recovery [13–15]. JTT has been used as an adjunctive therapy for advanced breast cancer patients [16].…”

Section: Discussionmentioning

confidence: 99%

The Long-Term Effects of a Kampo Medicine, Juzentaihoto, on Maintenance of Antibody Titer in Elderly People after Influenza Vaccination

Saiki

Koizumi

Goto

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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We have performed a broad-ranging analysis of the adjuvant effect of a Kampo medicine, juzentaihoto (JTT), on influenza vaccination in a multicenter randomized controlled trial. In this study, the enhancing effect of JTT on antibody titer after influenza vaccination was studied for 28 weeks in elderly people who were in the high-risk group for influenza infection. In total, 91 subjects over 65 years old were recruited from four long-term-care facilities located in Chiba, Gunma, and Toyama prefectures in Japan. Participants were randomly assigned to the JTT and the control groups. Blood samples were taken at 4 weeks before vaccination, at the time of vaccination, and then at 4, 8, 12, and 24 weeks after vaccination. The hemagglutination inhibition (HI) titers against A/California/7/2009 (H1N1), A/Victoria/210/2009 (H3N2), and B/Brisbane/60/2008 were then manually measured. A significant increase in HI titer against H3N2 was observed at week 8 after vaccination in the JTT group compared with the control group (P = 0.0229), and the HI titer of the JTT group significantly increased from 4 to 24 weeks (P = 0.0468), compared with the control group. In conclusion, our results indicated that JTT increased and prolonged antibody production against A/Victoria/210/2009 (H3N2), in particular, after influenza vaccination.

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Section: Discussionmentioning

confidence: 99%

The Long-Term Effects of a Kampo Medicine, Juzentaihoto, on Maintenance of Antibody Titer in Elderly People after Influenza Vaccination

Saiki

Koizumi

Goto

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…15 JTT is used clinically in East Asia to strengthen the immune functions of patients with various diseases, including cancer, 16,17 hepatitis C, 18 and otitis. 19 The formulation is a mixture of ten different herbs (see Table S1 in Supplementary data).…”

mentioning

confidence: 99%

Uncovering potential ‘herbal probiotics’ in Juzen-taiho-to through the study of associated bacterial populations

Montenegro

Kalpana

Chrissian

et al. 2015

Bioorganic & Medicinal Chemistry Letters

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Juzen-taiho-to (JTT) is an immune-boosting formulation of ten medicinal herbs. It is used clinically in East Asia to boost the human immune functions. The active factors in JTT have not been clarified. But, existing evidence suggests that lipopolysaccharide (LPS)-like factors contribute to the activity. To examine this possibility, JTT was subjected to a series of analyses, including high resolution mass spectrometry, which suggested the presence of structural variants of LPS. This finding opened a possibility that JTT contains immune-boosting bacteria. As the first step to characterize the bacteria in JTT, 16S ribosomal RNA sequencing was carried out for Angelica sinensis (dried root), one of the most potent immunostimulatory herbs in JTT. The sequencing revealed a total of 519 bacteria genera in A. sinensis. The most abundant genus was Rahnella, which is widely distributed in water and plants. The abundance of Rahnella appeared to correlate with the immunostimulatory activity of A. sinensis. In conclusion, the current study provided new pieces of evidence supporting the emerging theory of bacterial contribution in immune-boosting herbs.

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“…TJ-48 is known as a common Japanese herbal medicine which able to decrease Treg population in cancer patients (34). TJ-48 (2.0 g/kg/d) was administered for NOD mice from three weeks to 20 weeks of age.…”

Section: Tj-48mentioning

confidence: 99%

A new approach for treatment of type 1 diabetes: Phytotherapy and phytopharmacology of regulatory T cells

Mahmoudian-Sani¹,

Asadi-Samani²,

Luther³

et al. 2017

J Renal Inj Prev

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Orally administered Kampo medicine, Juzen-taiho-to, ameliorates anemia during interferon plus ribavirin therapy in patients with chronic hepatitis C

Abstract: These results indicate the possibility that oral administration of TJ-48 supports IFN/Rib therapy without necessitating ribavirin reduction or withdrawal.

Cited by 16 publications

References 5 publications

The Long-Term Effects of a Kampo Medicine, Juzentaihoto, on Maintenance of Antibody Titer in Elderly People after Influenza Vaccination

The Long-Term Effects of a Kampo Medicine, Juzentaihoto, on Maintenance of Antibody Titer in Elderly People after Influenza Vaccination

Uncovering potential ‘herbal probiotics’ in Juzen-taiho-to through the study of associated bacterial populations

A new approach for treatment of type 1 diabetes: Phytotherapy and phytopharmacology of regulatory T cells

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