Orally administered recombinant Lactobacillus expressing African swine fever virus antigens that induced immunity responses

Zhang, Hongliang; Zhao, Saisai; Zhang, Haojie; Shen, Yu; Zhang, Peijun; Huang, Shan; Cai, Xiulei

doi:10.3389/fmicb.2022.1103327

Cited by 15 publications

(15 citation statements)

References 33 publications

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“…In our laboratory, we expressed the p30, p54, and p72 proteins encoded by ASFV in vitro using the Lactobacillus lactis expression system. Findings suggested that recombinant Lactobacillus induced humoral, cellular, and local mucosal immunity via orally administered rabbits at a dose of 10 8 CFU/ml of combined immunization ( Zhang et al, 2023 ).…”

Section: Research Progress Of Asfv Vaccinesmentioning

confidence: 99%

Vaccines for African swine fever: an update

Zhang¹,

Zhao²,

Zhang³

et al. 2023

Front. Microbiol.

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African swine fever (ASF) is a fatal infectious disease of swine caused by the African swine fever virus (ASFV). Currently, the disease is listed as a legally notifiable disease that must be reported to the World Organization for Animal Health (WOAH). The economic losses to the global pig industry have been insurmountable since the outbreak of ASF. Control and eradication of ASF are very critical during the current pandemic. Vaccination is the optimal strategy to prevent and control the ASF epidemic, but since inactivated ASFV vaccines have poor immune protection and there aren’t enough cell lines for efficient in vitro ASFV replication, an ASF vaccine with high immunoprotective potential still remains to be explored. Knowledge of the course of disease evolution, the way of virus transmission, and the breakthrough point of vaccine design will facilitate the development of an ASF vaccine. In this review, the paper aims to highlight the recent advances and breakthroughs in the epidemic and transmission of ASF, virus mutation, and the development of vaccines in recent years, focusing on future directions and trends.

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Section: Research Progress Of Asfv Vaccinesmentioning

confidence: 99%

Vaccines for African swine fever: an update

Zhang¹,

Zhao²,

Zhang³

et al. 2023

Front. Microbiol.

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“…However, it is important to note that the ASF vaccine, though commercialized with products [46] like NAVET-ASFVAC and AVAC ASF LIVE, is not a flawless solution and has its limitations. Reliance on live attenuated strains may not provide sterilizing immunity [47], allowing vaccinated pigs to still become infected if exposed to wild ASF strains or other genotypes. Safety, although demonstrated under experimental conditions, poses potential adverse effects in the field.…”

Section: Asf Vaccine Practicality: Lessons From Fmd and Csf Managing ...mentioning

confidence: 99%

Strategies for Transboundary Swine Disease Management in Asian Islands: Foot and Mouth Disease, Classical Swine Fever, and African Swine Fever in Taiwan, Japan, and the Philippines

Hsu,

Chang,

Otake

et al. 2024

Veterinary Sciences

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Swine transboundary diseases pose significant challenges in East and Southeast Asia, affecting Taiwan, Japan, and the Philippines. This review delves into strategies employed by these islands over the past two decades to prevent or manage foot and mouth disease (FMD), classical swine fever (CSF), and African swine fever (ASF) in domestic pigs and wild boars. Despite socio-economic differences, these islands share geographical and climatic commonalities, influencing their thriving swine industries. Focusing on FMD eradication, this study unveils Taiwan’s success through mass vaccination, Japan’s post-eradication surveillance, and the Philippines’ zoning strategy. Insights into CSF in Japan emphasize the importance of wild boar control, whereas the ASF section highlights the multifaceted approach implemented through the Philippine National ASF Prevention and Control Program. This review underscores lessons learned from gained experiences, contributing to a comprehensive understanding of swine disease management in the region.

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“…The experimental pieces of evidence of this vaccine highlight reduced IAV shedding in pigs challenged 12 days post-vaccination [32]. Live attenuated vaccines (LAVs) are also used to control ASF and CSF [33]. Recent developments have sparked optimism regarding the potential for an effective and safe vaccine.…”

Section: Live/attenuated Vaccinesmentioning

confidence: 99%

A Comprehensive Review of Our Understanding and Challenges of Viral Vaccines against Swine Pathogens

Kamboj,

Dumka,

Saxena

et al. 2024

Viruses

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Pig farming has become a strategically significant and economically important industry across the globe. It is also a potentially vulnerable sector due to challenges posed by transboundary diseases in which viral infections are at the forefront. Among the porcine viral diseases, African swine fever, classical swine fever, foot and mouth disease, porcine reproductive and respiratory syndrome, pseudorabies, swine influenza, and transmissible gastroenteritis are some of the diseases that cause substantial economic losses in the pig industry. It is a well-established fact that vaccination is undoubtedly the most effective strategy to control viral infections in animals. From the period of Jenner and Pasteur to the recent new-generation technology era, the development of vaccines has contributed significantly to reducing the burden of viral infections on animals and humans. Inactivated and modified live viral vaccines provide partial protection against key pathogens. However, there is a need to improve these vaccines to address emerging infections more comprehensively and ensure their safety. The recent reports on new-generation vaccines against swine viruses like DNA, viral-vector-based replicon, chimeric, peptide, plant-made, virus-like particle, and nanoparticle-based vaccines are very encouraging. The current review gathers comprehensive information on the available vaccines and the future perspectives on porcine viral vaccines.

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Orally administered recombinant Lactobacillus expressing African swine fever virus antigens that induced immunity responses

Cited by 15 publications

References 33 publications

Vaccines for African swine fever: an update

Vaccines for African swine fever: an update

Strategies for Transboundary Swine Disease Management in Asian Islands: Foot and Mouth Disease, Classical Swine Fever, and African Swine Fever in Taiwan, Japan, and the Philippines

A Comprehensive Review of Our Understanding and Challenges of Viral Vaccines against Swine Pathogens

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