Orally Administered Trimethoprim-Sulfamethoxazole and Metronidazole as Infection Prophylaxis in Elective Colorectal Surgery

Abstract

Orally administered TSM as prophylaxis before elective colorectal surgery results in a low rate of organ/space SSI but an increased rate of incisional SSI compared with intravenously administered cefuroxime and metronidazole. Thus, when considering orally administered TSM, because of environmental concerns or for economic reasons, the slightly increased infection rate has to be kept in mind.

Mitigating Infection Risk in Upper Airway Stimulation

“…37,38 The efficacy of trimethoprim-sulfamethoxazole (Bactrim) as antibiotic prophylaxis with MRSA-and gram-negative coverage has also been explored across several surgical subspecialties such as plastic, orthopedic and colorectal with mixed results. [40][41][42] This study has several limitations that include its retrospective design and the small sample size with few explantation cases. This in turn limits the power in determining a difference in infection rates following protocol changes.…”

“…37,38 The efficacy of trimethoprim-sulfamethoxazole (Bactrim) as antibiotic prophylaxis with MRSA- and gram-negative coverage has also been explored across several surgical subspecialties such as plastic, orthopedic and colorectal with mixed results. 40 -42…”

The efficacy of bactrim in reducing surgical site infections after spine surgery

“…Bactrim (sulfamethoxazole/trimethoprim) is a very effective and popular treatment for gram-negative and MRSA infections. Therefore, Bactrim has been studied as a post-operative prophylactic oral antibiotic regime in multiple surgical specialties, such as vascular, colorectal, and neurosurgery [17] , [18] , [19] . The objective of this study is to look for the association of the post-operative prophylactic use of Bactrim and the gram-negative surgical site infection after lumbar spine surgery.…”