Orally Administered Xylo‐Oligosaccharides (XOS) Ameliorates Diarrhea Symptoms in Mice via Intestinal Barrier Improvement and Gut Microbiota Modulation

Abstract

Xylo‐oligosaccharides (XOS) has a bidirectional regulatory effect, and can be fermented by gut microbiota. This study aims to investigate how XOS alleviates Folium Sennae extracts induced diarrhea in mice. KM mice are given different concentration XOS for 3 weeks, and then Folium Sennae (Senna alexandrina Mill) extracts solutions (0.8 g mL−1) are given to establish diarrhea model. The results show that doses of XOS at 0.25 mg g−1 BW day−1 and higher could alleviate diarrhea symptoms by decreasing the disease activity indexes, down‐regulating pro‐inflammatory factors, up‐regulating anti‐inflammatory factor, and suppressing the intestinal permeability in colon tissues. XOS also regulates the composition of gut microbiota via increasing the abundance Prevotellaceae, Ruminococcus, and Bifidobacterium. The results suggest that the dietary supplementation XOS could be a more effective choice to prevent and alleviate diarrhea.

Dietary xylo-oligosaccharides and arabinoxylans improved growth efficiency by reducing gut epithelial cell turnover in broiler chickens

“…Several studies have reported the impact of dietary XOS supplementation on improving growth performance in chickens [ 14 , 17 , 40 – 44 ]. This positive effect has been associated with their capacity to modulate the gut microbiota, regulate the immune function, and enhance gut health [ 16 , 19 , 45 , 46 ]. In addition, AX supplementation have also been reported in the literature [ 47 – 49 ].…”

Xylooligosaccharides from corn cobs alleviate loperamide-induced constipation in mice via modulation of gut microbiota and SCFA metabolism

“…23 XOS dietary supplementation has been demonstrated in numerous published research studies to change the gut microbiota's composition by enhancing the abundance of Bifidobacterium and Lactobacillus . 24,25 XOSs demonstrated an anti-constipation effect by increasing fecal moisture and the number of Bifidobacterium species. 26 However, the precise mechanisms underpinning XOSs from corn cobs to treat constipation effectively are still entirely unclear.…”

Xylo-oligosaccharides improve the adverse effects of plant-based proteins on weaned piglet health by maintaining the intestinal barrier and inhibiting harmful bacterial growth

“…Previous studies have demonstrated that XOS improved the growth performance, immune function, and antioxidant activity of weaned piglets (Pang et al, 2021b ). In addition, XOS contributed to maintaining the integrity of the intestinal barrier (Tong et al, 2022 ), antibacterial activity (Pang et al, 2021a ), and anti-inflammatory properties (Ding et al, 2018 ). The research showed that xylo-oligosaccharides of 100 g/t could significantly increase the content of short-chain fatty acids (SCFA) in piglets (Su et al, 2021 ).…”