2024
DOI: 10.1002/iid3.1333
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Orally administered yeast‐derived β‐glucan alleviates mast cell‐dependent airway hyperresponsiveness and inflammation in a murine model of asthma

Jianzhou Zheng,
Yu Bai,
Lei Xia
et al.

Abstract: BackgroundParticulate β‐glucans (WGP) are natural compounds with regulatory roles in various biological processes, including tumorigenesis and inflammatory diseases such as allergic asthma. However, their impact on mast cells (MCs), contributors to airway hyperresponsiveness (AHR) and inflammation in asthma mice, remains unknown.MethodsC57BL/6 mice underwent repeated OVA sensitization without alum, followed by Ovalbumin (OVA) challenge. Mice received daily oral administration of WGP (OAW) at doses of 50 or 150… Show more

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