2019
DOI: 10.7150/thno.38081
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Orally Deliverable Nanotherapeutics for the Synergistic Treatment of Colitis-Associated Colorectal Cancer

Abstract: Purpose: Colitis-associated colorectal cancer (CAC) poses substantial challenges for effective treatment. Currently, there is a considerable need for the development of orally bioavailable dosage forms that enable the safe and effective delivery of therapeutic drugs to local diseased lesions in the gastrointestinal tract.Experimental Design: In this study, we developed orally deliverable nanotherapeutics for the synergistic treatment of inflammatory bowel diseases (IBDs) and CAC. Water-insoluble curcumin (CUR)… Show more

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Cited by 87 publications
(59 citation statements)
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“…In 2019, Han et al expanded the use of bioadhesive chitosan materials on colloidal-stable nanotherapeutics. This exhibited safe and precise accumulation to local diseased lesions in the gastrointestinal tract 6 Mediators of Inflammation [136]. In 2018, Zahra et al utilized intestinal organoids as carriers of 5-ASA-loaded poly nanoparticles to alleviate IBD [137].…”
Section: The Clinical Potential Of Evs On Treatmentmentioning
confidence: 99%
“…In 2019, Han et al expanded the use of bioadhesive chitosan materials on colloidal-stable nanotherapeutics. This exhibited safe and precise accumulation to local diseased lesions in the gastrointestinal tract 6 Mediators of Inflammation [136]. In 2018, Zahra et al utilized intestinal organoids as carriers of 5-ASA-loaded poly nanoparticles to alleviate IBD [137].…”
Section: The Clinical Potential Of Evs On Treatmentmentioning
confidence: 99%
“…[48]. For this purpose, Han et al [49] tried out orally deliverable nanotherapeutics by combining water-insoluble curcumin and 7-ethyl-10-hydroxycamptothecin (SN38) which is the active metabolite of irinotecan. They studied the effects of this formulation on inflammatory bowel disease (IBD) and CRC in a mouse model.…”
Section: In Vivo Studies: the Effect Of Curcumin On Colorectal Cancermentioning
confidence: 99%
“…In the fashion of poorly soluble small molecule anticancer drugs 68 , 69 , TKIs are recently in the focus of nanomedicine research. Recent review written by Moradpour and Barghi discusses different types of targeted delivery of TKIs 70 .…”
Section: Nanomedicinementioning
confidence: 99%