Orally ingestible medical devices for gut engineering

Mandsberg, Nikolaj Kofoed; Christfort, Juliane Fjelrad; Kamguyan, Khorshid; Boisen, Anja; Srivastava, Sarvesh Kumar

doi:10.1016/j.addr.2020.05.004

Cited by 54 publications

(28 citation statements)

References 99 publications

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“…Recently, researchers have started to explore microdevices’ production by biodegradable polymers that can be orally ingested for drug delivery, imaging, and sensing. Materials such as polysaccharides (e.g., alginates, dextran, and chitosan) and protein-based polymers (e.g., gelatin) have been considered for these devices, yet they can be hardly scalable due to difficult processing and the high costs of extraction and purification from natural resources [ 49 ]. Nonetheless, several prototypes were designed.…”

Section: Fabrication Of Microfluidic Devicesmentioning

confidence: 99%

Fabrication and Applications of Microfluidic Devices: A Review

Niculescu

Chircov

Bîrcă

et al. 2021

IJMS

382

208

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Microfluidics is a relatively newly emerged field based on the combined principles of physics, chemistry, biology, fluid dynamics, microelectronics, and material science. Various materials can be processed into miniaturized chips containing channels and chambers in the microscale range. A diverse repertoire of methods can be chosen to manufacture such platforms of desired size, shape, and geometry. Whether they are used alone or in combination with other devices, microfluidic chips can be employed in nanoparticle preparation, drug encapsulation, delivery, and targeting, cell analysis, diagnosis, and cell culture. This paper presents microfluidic technology in terms of the available platform materials and fabrication techniques, also focusing on the biomedical applications of these remarkable devices.

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Section: Fabrication Of Microfluidic Devicesmentioning

confidence: 99%

Fabrication and Applications of Microfluidic Devices: A Review

Niculescu

Chircov

Bîrcă

et al. 2021

IJMS

382

208

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“…Microfabricated devices render a new approach for delivering active compounds to specific sites in the GI tract [11][12][13] and have great potential for colon-specific oral delivery of next-generation probiotic organisms 14 . Microcontainers, i.e.…”

Section: Introductionmentioning

confidence: 99%

Colon-Specific Delivery of Bioactive Agents Using Genipin-Cross-Linked Chitosan Coated Microcontainers

Kamguyan

Torp

Christfort

et al. 2020

ACS Appl. Bio Mater.

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“…It then deploys milliposts fabricated from drugs directly through the intestinal mucosa while avoiding perforation. Figure 5 demonstrates the device positions to the stomach lining, orients its injection of the drug payload toward the GIT wall 96 . This SOMA device has demonstrated promising efficacy to deliver insulin orally and could be used to deliver other PPDs orally.…”

Section: Strategies To Enhance Oral Bioavailability Of Ppdsmentioning

confidence: 99%

Oral delivery of protein and peptide drugs: from non-specific formulation approaches to intestinal cell targeting strategies

Chen¹,

Kang²,

Li³

et al. 2022

Theranostics

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The past few years has witnessed a booming market of protein and peptide drugs, owing to their superior efficiency and biocompatibility. Parenteral route is the most commonly employed method for protein and peptide drugs administration. However, short plasma half-life protein and peptide drugs requires repetitive injections and results in poor patient compliance. Oral delivery is a promising alternative but hindered by harsh gastrointestinal environment and defensive intestinal epithelial barriers. Therefore, designing suitable oral delivery systems for peptide and protein drugs has been a persistent challenge. This review summarizes the main challenges for oral protein and peptide drugs delivery and highlights the advanced formulation strategies to improve their oral bioavailability. More importantly, major intestinal cell types and available targeting receptors are introduced along with the potential strategies to target these cell types. We also described the multifunctional biomaterials which can be used to prepare oral carrier systems as well as to modulate the mucosal immune response. Understanding the emerging delivery strategies and challenges for protein and peptide drugs will surely inspire the production of promising oral delivery systems that serves therapeutic needs in clinical settings.

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Orally ingestible medical devices for gut engineering

Cited by 54 publications

References 99 publications

Fabrication and Applications of Microfluidic Devices: A Review

Fabrication and Applications of Microfluidic Devices: A Review

Colon-Specific Delivery of Bioactive Agents Using Genipin-Cross-Linked Chitosan Coated Microcontainers

Oral delivery of protein and peptide drugs: from non-specific formulation approaches to intestinal cell targeting strategies

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