Orange pulp improves antioxidant status and suppresses lipid peroxidation in orchidectomized male rats

Deyhim, Farzad; Villarreal, Arnulfo; Garcia, Kristi; Rios, Ryan; García, Claudia; Gonzales, Cheri; Mandadi, Kranthi K.; Patil, Bhimanagouda S.

doi:10.1016/j.nut.2007.04.009

Cited by 18 publications

(2 citation statements)

References 26 publications

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“…These free radicals modulate intraand inter-cellular signaling responsible for bone loss [113]. Castrated rats are more likely to develop osteoporosis, and this can be prevented with antioxidants, such as orange and grapefruit pulps [114,115]. Similarly, citrus bioactive compounds have been shown to decrease oxidative stress and improve bone quality in castrated rats [116].…”

Section: (1) Interaction Between Oxidative Stress and Ar Signaling Inmentioning

confidence: 99%

Oxidative stress and androgen receptor signaling in the development and progression of castration-resistant prostate cancer

Shiota

Yokomizo

Naito

2011

Free Radical Biology and Medicine

107

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Aberrant androgen receptor (AR) signaling plays a critical role in androgen-dependent prostate cancer (PCa), as well as in castration-resistant PCa (CRPC). Oxidative stress seems to contribute to the tumorigenesis and progression of PCa, as well as the development of CRPC, via activation of AR signaling. This notion is supported by the fact that there is an aberrant or improper regulation of the redox status in these disorders. Additionally, androgen-deprivation-induced oxidative stress seems to be involved in the pathogenesis of several disorders caused by androgen-deprivation therapy (ADT), including osteoporosis, neurodegenerative disease, and cardiovascular disease. Oxidative stress can be suppressed with antioxidants or via a reduction in reactive oxygen species production. Thus, developing new therapeutic agents that reduce oxidative stress might be useful in preventing the conversion of androgen-dependent PCa into CRPC, as well as reducing the adverse effects associated with ADT. The objective of this review is to provide an overview regarding the relationship between oxidative stress and AR signaling in the context of PCa and especially CRPC. Additionally, we discuss the potential use of antioxidant therapies in the treatment of PCa.

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Section: (1) Interaction Between Oxidative Stress and Ar Signaling Inmentioning

confidence: 99%

Oxidative stress and androgen receptor signaling in the development and progression of castration-resistant prostate cancer

Shiota

Yokomizo

Naito

2011

Free Radical Biology and Medicine

107

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“…Oranges and other citrus products contain essential oils (e.g., limonene, linalool) that are toxic to bacteria (Kim et al, 1995;Fisher and Phillips, 2006) and exhibit antioxidant effects in host animals (Dusan et al, 2006;Deyhim et al, 2007). Orange peel and dried orange pulp are a by-product of orange juice production that has a relatively high nutritive value and is available at low prices in citrus-producing regions (e.g., Florida and California).…”

Section: Introductionmentioning

confidence: 99%

Citrus Products Decrease Growth of E. coli O157:H7 and Salmonella Typhimurium in Pure Culture and in Fermentation with Mixed Ruminal Microorganisms In Vitro

Callaway

Carroll

Arthington

et al. 2008

Foodborne Pathogens and Disease

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Orange peel and orange pulp are by-products that are included in feedlot and dairy cattle diets because of their low cost and high nutritional quality. The antimicrobial activity of citrus oils has been reported previously. The present study was carried out to determine whether these citrus by-products exert antimicrobial effects on Escherichia coli O157:H7 and Salmonella Typhimurium populations that are found in cattle gastrointestinal tracts. The growth of pure cultures (n = 3) of E. coli O157:H7 and Salmonella Typhimurium were reduced (p < 0.05) by addition of 2% (w/v) orange pulp and orange peel. Ruminal fluid was collected from cattle (n = 2) and E. coli O157:H7 or Salmonella Typhimurium were added. The addition of orange pulp and peel to in vitro mixed ruminal microorganism fermentations (n = 3) demonstrated that both orange pulp and peel reduced E. coli O157:H7 and Salmonella Typhimurium populations at least 2 log(10) in mixed ruminal fluid fermentations. Addition of orange pulp reduced (p < 0.05) E. coli O157:H7 populations from 10(5) to 10(2) colony-forming units (CFU)/mL and Salmonella Typhimurium populations (p < 0.05) from 10(4) to 10(2) CFU/mL. These results indicate that orange pulp and/or peel included in ruminant diets could decrease ruminal populations of foodborne pathogenic bacteria. Further research is needed to determine whether the antimicrobial activity of orange products against E. coli O157:H7 or Salmonella Typhimurium is expressed in the lower gastrointestinal tract.

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Citrus Flavanones and Bone Health

Horcajada

Offord

2013

Nutritional Influences on Bone Health

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Orange pulp improves antioxidant status and suppresses lipid peroxidation in orchidectomized male rats

Cited by 18 publications

References 26 publications

Oxidative stress and androgen receptor signaling in the development and progression of castration-resistant prostate cancer

Oxidative stress and androgen receptor signaling in the development and progression of castration-resistant prostate cancer

Citrus Products Decrease Growth of E. coli O157:H7 and Salmonella Typhimurium in Pure Culture and in Fermentation with Mixed Ruminal Microorganisms In Vitro

Citrus Flavanones and Bone Health

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