Orbital and Eyelid B-Cell Lymphoma: A Multicenter Retrospective Study

Savino, Gustavo; Midena, Giulia; Blasi, Maria Antonietta; Battendieri, Remo; Grimaldi, Gabriela; Maceroni, Martina; Tranfa, Fausto; Napolitano, Pasquale; Lanni, Vittoria; Iuliano, Adriana

doi:10.3390/cancers12092538

Cited by 11 publications

(11 citation statements)

References 57 publications

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“…We found only a slightly MALT lymphoma predominance in general orbital lymphoma which is consistent with previous reports 2,11 . However, in other studies, especially from Asia, the incidence of MALT lymphoma was significantly higher, ranging from 66% to 82% of total orbital lymphoma 1,3,12,13 . Unexpectedly, among non‐MALT lymphoma, almost 30% of patients had diffuse large‐cell lymphoma.…”

Section: Discussionsupporting

confidence: 91%

“… 2 , 11 However, in other studies, especially from Asia, the incidence of MALT lymphoma was significantly higher, ranging from 66% to 82% of total orbital lymphoma. 1 , 3 , 12 , 13 Unexpectedly, among non‐MALT lymphoma, almost 30% of patients had diffuse large‐cell lymphoma. Only 7% of patients had mantle cell lymphoma and 4% of patients had follicular lymphoma.…”

Section: Discussionmentioning

confidence: 99%

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A survey across orbital lymphoma in Poland: Multicenter retrospective study of polish lymphoma research group (PLRG)

et al. 2022

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Objective To investigate the prevalence of histopathological subtypes, the clinical stage at presentation and treatment modalities in Polish patients with orbital lymphoma (OL) and to determine prognostic outcomes. Methods The retrospective study of 107 patients with OL treated in a 14‐year period in Polish hematological centers. The analysis included histopathological subtype, disease clinical advancement, treatment modalities, progression‐free survival (PFS), and overall survival (OS). Results The median patient age was 60 years (range 51–71). Mucosa‐associated lymphoid tissue (MALT) lymphoma accounted for slightly more than half of all cases of orbital lymphoma (51%). The second most common subtype was diffuse large B‐cell lymphoma (DLBCL) (29%). Primary orbital lymphoma was diagnosed in 48% of all patients. According to the Ann Arbor, localized stage IE of orbital lymphoma was diagnosed only in 39% of all patients. Systemic involvement was observed in more than half of all patients (52%). The median follow‐up period was 30 months (range 0–160 months). Patients with non‐MALT lymphoma had a significantly inferior PFS compared to patients with MALT lymphoma, ( p = 0.047). Patients with primary orbital lymphoma had a superior PFS compared to patients with secondary orbital lymphoma [median PFS 104.5 months vs. 33.4 months], ( p = 0.069). Younger patients with MALT lymphoma were characterized by superior PFS (median PFS not reached) compared to other studied subgroups of patients (older patients with MALT lymphoma, younger and older non‐MALT lymphoma patients) with a median PFS of 30.5, 32.2, 32.6 months respectively ( p = 0.039). Patients treated with chemotherapy alone had inferior PFS compared to patients treated with combined therapies ( p = 0.034). The median PFS across patients who received chemotherapy alone was 23.7 months, whereas across other patients was 73.9 months. Conclusions Secondary lymphoma accounts for more than half of the orbital lymphoma in Polish population. The advanced clinical stage of the disease (non‐IE according to Ann Arbor) concerns two‐thirds of the overall population of patients with orbital lymphomas and one‐third of MALT lymphoma patients. The high incidence of advanced stages of orbital lymphoma may indicate the need for combined treatment. Combined orbital lymphoma treatment is associated with superior PFS compared to chemotherapy alone in overall population of patients with orbital lymphoma.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

A survey across orbital lymphoma in Poland: Multicenter retrospective study of polish lymphoma research group (PLRG)

et al. 2022

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“…Ki-67 may show a lower proliferation index than usual in reactive follicles. 1 In this case, the patient had a very atypical involvement of the skin, with bilateral and symmetric eyelid nodules limiting the palpebral opening. The diagnosis of cutaneous follicle center lymphoma was confirmed on 2 skin biopsies with an extension assessment ruling out systemic or lymph node involvement.…”

Section: Discussionmentioning

confidence: 86%

Cutaneous follicle center lymphoma of the eyelids: Unusual location

Jihane¹,

Sara²,

Znati³

et al. 2022

JAAD Case Reports

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“…FL belongs to low-grade lymphoma, while DLBCL and BL are high-grade lymphoma. Savino G et al 4 . in their studies from Asia found that the diffuse large B-cell lymphoma was the second subtype of orbital lymphoma, and more than half of the patient had systemic involvement, such as fever, night sweats, or weight loss.…”

Section: Discussionmentioning

confidence: 99%

A case of primary orbital lymphoma manifested as increased intraocular pressure

Sun

Zhou

et al. 2023

Preprint

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Background Orbital lymphoma may occur with or without systemic symptoms. Lymphoma can influence any different soft tissue structure in the orbital cavity except the orbital bone, and exhibit similar clinical and imaging features to other orbital diseases, so it is often misdiagnosed. The pathogenesis of lymphoma is closely related to the prognosis. Early diagnosis of the disease is beneficial to the definition and treatment of the disease, and can increase the survival time of the patient. Case presentation: An elderly man presented to local hospital with sudden eyelid swelling and vision loss in his left eye. During the follow-up treatment, the intraocular pressure of the patient's left eye increased gradually and the visual acuity gradually decreased to no light perception. We performed CT-guided puncture of the orbital mass. The pathological findings suggested small cell malignancy. Combined with the clinical manifestations and signs, the patient was considered to be ocular non-Hodgkin diffuse large B-cell lymphoma. Then the patient was given combined chemotherapy and radiotherapy. After the treatment, the patient's eye swelling and pain were significantly improved. Conclusions To the best of our knowledge, this is one of the few described cases of orbital lymphomas that begin with increased intraocular pressure.

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Orbital and Eyelid B-Cell Lymphoma: A Multicenter Retrospective Study

Cited by 11 publications

References 57 publications

A survey across orbital lymphoma in Poland: Multicenter retrospective study of polish lymphoma research group (PLRG)

A survey across orbital lymphoma in Poland: Multicenter retrospective study of polish lymphoma research group (PLRG)

Cutaneous follicle center lymphoma of the eyelids: Unusual location

A case of primary orbital lymphoma manifested as increased intraocular pressure

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