Orbital apex syndrome due to invasive aspergillosis in an immunocompetent patient

Abstract

Infection is a rare cause of orbital apex syndrome (OAS) and most commonly occurs in immunocompromised hosts. We report a case of OAS in an elderly immunocompetent female due to invasive aspergillosis and Staphylococcus aureus co-infection. The patient required both surgical debridement and prolonged courses of antibiotic and antifungal therapy. Invasive fungal disease must be considered in cases of OAS, even in patients without classic risk factors.

Sinonasal Orbital Apex Syndrome, Horner Syndrome and Pterygopalatine Fossa Infection: A Case Report and Mini-Review

“…There were no obvious identified risk factors for the development of invasive fungal RS as the patient did not have immunodeficiency or disease such as diabetes mellitus [ 25 ] or haematological malignancy [ 18 ]. These findings are consistent with the previously reported cases of invasive rhino-orbital-cerebral aspergillosis and invasive oronasal aspergillosis in immunocompetent patients [ 19 , 21 , 22 , 23 ].…”

Orbital Apex Syndrome caused by invasive aspergillosis in patient with post-Covid-19 infection - A case report

“…In OAS due to Aspergillosis urgent treatment is necessary to avoid complications such as complete vision loss and cavernous sinus thrombosis. High index of suspicion is necessary to diagnose and prompt treatment in OAS due to aspergillosis [5] .…”

Progression of chronic rhinosinusitis to invasive cerebro-orbital aspergillosis following steroid treatment: A case of induced immunosuppression

“…However, it may sometimes develop into invasive infection, commonly in immunocompromised individuals [3] , [4] . Recently, there has been a substantial increase in the number of reported acute invasive fungal infections in immunocompetent individuals [3] , [5] , [6] , [7] , [8] , [9] , [10] , [11] . We present a case of an immunocompetent young adult initially presenting with CRSwNP who then developed invasive aspergillosis with cerebral and orbital involvement.…”