Due to the chiral nature of electrons in a monolayer of graphite (graphene) one can expect weak antilocalisation and a positive weak-field magnetoresistance in it. However, trigonal warping (which breaks p → −p symmetry of the Fermi line in each valley) suppresses antilocalisation, while intervalley scattering due to atomically sharp scatterers in a realistic graphene sheet or by edges in a narrow wire tends to restore conventional negative magnetoresistance. We show this by evaluating the dependence of the magnetoresistance of graphene on relaxation rates associated with various possible ways of breaking a 'hidden' valley symmetry of the system. The chiral nature [1,2,3,4] of quasiparticles in graphene (monolayer of graphite), which originates from its honeycomb lattice structure and is revealed in quantum Hall effect measurements [5,6], is attracting a lot of interest. In recently developed graphene-based transistors [5,6] the electronic Fermi line consists of two tiny circles [7] surrounding corners K ± of the hexagonal Brillouin zone [8], and quasiparticles are described by 4-, which characterise electronic amplitudes on two crystalline sublattices (A and B), and the HamiltonianHere, we use direct products of Pauli matrices σ x,y,z , σ 0 ≡1 acting in the sublattice space (A, B) and Π x,y,z , Π 0 ≡1 acting in the valley space (K ± ) to highlight the form ofĤ in the non-equivalent valleys [8]. Near the center of each valley electron dispersion is determined by the Dirac-type part v σp ofĤ. It is isotropic and linear. For the valley K + the electronic excitations with momentum p have energy vp and are chiral with σp/p = 1, while for holes the energy is −vp and σp/p = −1. In the valley K − , the chirality is inverted: it is σp/p = −1 for electrons and σp/p = 1 for holes. The quadratic term in Eq. (1) violates the isotropy of the Dirac spectrum and causes a weak trigonal warping [8].Due to the chirality of electrons in a graphene-based transistor, charges trapped in the substrate or on its surface cannot scatter carriers in exactly the backwards direction [2,7], provided that they are remote from the graphene sheet by more than the lattice constant. In the theory of quantum transport [9] the suppression of backscattering is associated with weak anti-localisation (WAL) [10]. For purely potential scattering, possible WAL in graphene has recently been related to the Berry phase π specific to the Dirac fermions, though it has also been noticed that conventional weak localisation (WL) may be restored by intervalley scattering [11,12].In this Letter we show that the WL magnetoresistance in graphene directly reflects the degree of valley symmetry breaking by the warping term in the free-electron Hamiltonian (1) and by atomically sharp disorder. To describe the valley symmetry, we introduce two sets of 4×4 Hermitian matrices: 'isospin' Σ = (Σ x , Σ y , Σ z ) and 'pseudospin' Λ = (Λ x , Λ y , Λ z ). These are defined asand form two mutually independent algebras, [ Σ, Λ] = 0, The Dirac part ofĤ in Eq. (4), v Σp and potenti...