Orbital eosinophilic granuloma in a child: a case report

Kahiloğulları, Gökmen; Tuna, Hakan; Kuzu, Işınsu; Ünlü, Ağahan

doi:10.5137/1019-5149.jtn.6026-12.0

Cited by 4 publications

(7 citation statements)

References 8 publications

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“…Literature review in PubMed yielded 68 results using the terms “langerhans cell histiocytosis and orbit” of which there are 15 applicable results outlined below. There were no complications with treatment 1,9–22 …”

Section: Discussionmentioning

confidence: 98%

Successful treatment of orbital Langerhans cell histiocytosis with stereotactic radiosurgery: A case report and literature review

Etter

Bosse

Wang

et al. 2023

Clinical Case Reports

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Langerhans cell histiocytosis (LCH) is a rare inflammatory myeloid neoplasm arising from the proliferation of pathologic Langerhans cells. LCH has a spectrum of presentations predominantly affecting male pediatric patients. As LCH is a relatively uncommon diagnosis, there is no standard of care for treatment of the disease and treatment is based largely on clinical judgment, lesion characteristics, and symptoms at presentation. Here we present a case of unifocal, isolated orbital LCH in a 19-year-old young man treated initially with surgical resection. Follow-up imaging 2 months later demonstrated significant regrowth of the mass and no other sites of disease. The recurrent orbital disease was treated with stereotactic radiosurgery (SRS) to 7 Gy in one fraction. Near complete resolution of the mass was achieved with no recurrence after 1.5 years of follow-up. SRS for treatment of orbital LCH is a novel treatment not previously described in the literature which may provide benefit in select cases.

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Section: Discussionmentioning

confidence: 98%

Successful treatment of orbital Langerhans cell histiocytosis with stereotactic radiosurgery: A case report and literature review

Etter

Bosse

Wang

et al. 2023

Clinical Case Reports

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“…LHH, nadiren otoimmun bir hastalığın manifestasyonu ya da atipik immunolojik reaksiyonla kendini gösterebilen ve nedeni bilinmeyen non-neoplastik spesifik inflamatuar bir hastalık grubudur. [12] Hastalık, Eosinofilik granülom (kronik lokal formu), Hand-Schüller-Christian hastalığı (kronik yaygın formu) ve Letterer-Siwe hastalığı (akut yaygın formu) olmak üzere üç ayrı formda incelenmektedir [13]. EG, langerhans hücreli histiositozisin tipik kemik lezyonu ile tanımlanan en yaygın formudur [14].…”

Section: Discussionunclassified

“…EG, nispeten nadir görülen bir hastalık olup, tüm tümör benzeri kemik lezyonlarının %1'inden azını oluşturur [15]. EG, en sık tutulum yeri kafatasıdır [12]. Kafatasında, sıklıkla frontal, paryetal ve temporal kemikte lezyona neden olur [16].…”

Section: Discussionunclassified

Oksipital kemik yerleşimli langerhans hücreli histiyositoz: Olgu sunumu

Terzi¹,

Korkmaz²,

Çiçekli³

et al. 2014

Cumhuriyet Med J

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ÖzetLangerhans Hücreli Histiyositozis aynı histopatolojiye sahip fakat farklı klinik semptomlara neden olan hastalıklar grubu olarak adlandırılmaktadır. Üç ayrı formu olan hastalığın lokalize formu Eozinofilik granulom olarak isimlendirilmektedir. Eosinofilik granülom, Langerhans Hücreli Histiyositozis grubu içerisinde klinik seyri en az şiddetli ve lokalize form olup en iyi prognoza sahip alt tiptir. Tedavi şeçenekleri arasında, cerrahi eksizyon, kemoterapi, radyoterapi tek başına kullanılabileceği gibi kombine kullanımları da bulunmaktadır. Burada, sağ oksipital bölgede şişlik ve ağrı şikayeti ile kliniğimize başvuran, radyolojik tetkikleri ve histopatolojik incelemesi sonucunda Langerhans Hücreli Histiyositozis (Eosinifilik granülom) tanısı alan genç erişkin bir hasta sunuldu.

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“…Following independent then joint review of titles and abstracts, 122 articles were selected for full review. Forty-five 8-52 of these were chosen for data extraction, from which 201 pediatric patients were identified with isolated bone lesion in the head and neck with specified management ( Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%