Orbital Inflammatory Syndrome and Systemic Lupus Erythematosus

Orbital inflammatory disease management

“…Within the orbit and periorbital region, SLE can have different presentations including panniculitis, diffuse orbital inflammation, eyelid edema, trochleitis, and myositis [129][130][131][132][133][134][135][136][137][138][139][140][141].…”

“…In most cases, the patient were know to have SLE prior to orbital involvement and hence were undergoing systemic immunosuppressant therapy at the time of orbital presentation. Nonetheless, corticosteroids have been shown to effectively manage orbital and periorbital manifestations of SLE with minimal recurrence [129][130][131][133][134][135][136][138][139][140][141].…”

Non-infectious orbital vasculitides

“…In most of these cases, patients had an elevated ANA and ds-DNA along with other systemic symptoms consistent with SLE. [81][82][83][84][85][86][87][88][89][90][91] Arthurs et al 81 described a case of a patient who developed exophthalmos secondary to an orbital mass; biopsy of the mass demonstrated evidence of a pseudotumor with vascular inflammation. This patient eventually developed infarction and subsequent disintegration of orbital structures.…”

“…Patients in the literature have been successfully treated with oral or IV glucocorticoids. [81][82][83][84][85][86][87][88][89][90][91][92][93] Most patients had complete resolution of symptoms after initiating therapy, although there were four cases in which the patients had a recurrence of disease and needed an increase in dosage. [89][90][91] Treatment with steroids was always in addition to their ongoing treatment for SLE or RA.…”

Orbital myositis as manifestation of Systemic Lupus Erythematosus - a case report

“…It is mostly unilateral and remains largely a diagnosis of exclusion. Important differentials which should be ruled out by initial investigations include infectious, endocrine (essentially, Grave's opthalmopathy), infiltrative (sarcoidosis) and neoplastic causes 2. Systemic SLE activity is not always noted at onset of the ocular manifestations hence a high index of suspicion should be maintained in predisposed patients.…”