Orbital invasion despite topical anti-metabolite therapy for conjunctival carcinoma

Abstract

While topical agents are important in treatment of conjunctival neoplasia, recurrence or deep invasion require careful monitoring.

Adjuvant 5-fluorouracil in the treatment of localised ocular surface squamous neoplasia

“…Our concern is that topical 5-FU, while potent against the rapidly dividing squamous cells at the ocular surface, will have limited efficacy against poorly differentiated squamous neoplasia beneath the basement membrane. We note that in a number of published cases, orbital invasion has occurred despite topical chemotherapy for invasive SCC 9 23…”