2014
DOI: 10.1080/08998280.2014.11929159
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Orbital Liposarcoma Masquerading as a Hemangioma

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Cited by 7 publications
(7 citation statements)
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“…1,3,7,9–11,15,16,20 While ALT/WDL tumors make up 40% to 45% of liposarcomas, 21 the majority of liposarcomas involving the orbit were previously reported to be of the myxoid type (57%), followed by ALT/WDL (30%) and pleomorphic (11%). 1 However, upon the authors’ review of 63 documented cases of primary orbital liposarcoma in the English literature (including the authors’), 42.9% (n = 27) were ALT/WDL, 2–16 39.7% (n = 25) were myxoid, 1,7,13,20,22–33 8.9% (n = 6) were pleomorphic, 1,3,22,34–36 and 7.5% (n = 5) were dedifferentiated liposarcomas. 3,20,37–39 Excluding dedifferentiated cases, the breakdown was found to be 46.5% ALT/WDL, 43.1% myxoid, and 10.3% pleomorphic liposarcoma, suggesting that ALT/WDL is more common in the orbit than previously thought.…”
Section: Discussionmentioning
confidence: 98%
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“…1,3,7,9–11,15,16,20 While ALT/WDL tumors make up 40% to 45% of liposarcomas, 21 the majority of liposarcomas involving the orbit were previously reported to be of the myxoid type (57%), followed by ALT/WDL (30%) and pleomorphic (11%). 1 However, upon the authors’ review of 63 documented cases of primary orbital liposarcoma in the English literature (including the authors’), 42.9% (n = 27) were ALT/WDL, 2–16 39.7% (n = 25) were myxoid, 1,7,13,20,22–33 8.9% (n = 6) were pleomorphic, 1,3,22,34–36 and 7.5% (n = 5) were dedifferentiated liposarcomas. 3,20,37–39 Excluding dedifferentiated cases, the breakdown was found to be 46.5% ALT/WDL, 43.1% myxoid, and 10.3% pleomorphic liposarcoma, suggesting that ALT/WDL is more common in the orbit than previously thought.…”
Section: Discussionmentioning
confidence: 98%
“…12 One study had utilized comparative genomic hybridization to detect chromosomal abnormalities, and 6 of the cases had detected MDM2 amplification with FISH. 6,9,12,15,16 Utilization of molecular studies may be of significant value particularly in cases with overlapping features of other lipomatous tumors and conditions. McKey et al 16 demonstrated a case of a spindle cell/pleomorphic lipoma (based on histopathological features) until it was confirmed to be ALT/WDL by FISH, which demonstrated amplification of MDM2 and CDK4 .…”
Section: Discussionmentioning
confidence: 99%
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“…The rarity of HNLS is clearly demonstrated by the small number of cases reported in the major series, such as the 30 cases in 60-year timeframe of MD Anderson Center, 12 and the 9 cases reported in the 30-year interval series of Mayo Clinic 6 . The orbital location of liposarcomas is extremely rare with around 40 cases reported in English literature, mainly in form of case-report16, 17, 18 or small series 19 widely scattered with respect to clinical history, presentation and histological subtype. In the largest study population of 318 HNLS derived from the register of Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute, 3 the distribution for primary site was: subcutaneous tissue of face, neck and scalp, oral cavity, skin, salivary glands, and upper aerodigestive tract in decreasing order of frequency; surprisingly the study did not report any case of orbital location, confirming the extreme rarity of this subgroup of HNLS.…”
Section: Discussionmentioning
confidence: 99%