Orbital metastasis as presenting symptom from a prostatic adenocarcinoma

Pastore, Marco R; D’Aloisio, Rossella; Cirigliano, Gabriella; Giacinto, Chiara De; Tognetto, Daniele

doi:10.1177/1120672119832182

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…We have reviewed 15 published cases of prostate metastasis to the GWS and added 6 of our own cases. 57–68 Two cases, including 1 of our own, had bilateral GWS metastases (Figure 7). 62 Of these 21 cases, 18 (85.7%) showed an osteoblastic (or hyperostotic) response, 2/21 (9.5%) showed a purely osteolytic response, and 3/21 (14.3%) showed a mixture of osteoblastic and osteolytic change.…”

Section: Resultsmentioning

confidence: 81%

“…The list of our own and published lesions appears in Table 2. 2–99 Published cases of 4 of the listed diagnoses were not reviewed because there is a significant literature on these already (sickle cell crisis with sphenoid infarction, tuberculosis of orbital bone, sphenoid bone dysplasia in NF1, and fibrous dysplasia of bone). During the same period as these new cases were collected from our practices, 97 cases (21 males) of spheno-orbital meningioma were encountered by us.…”

Section: Resultsmentioning

confidence: 99%

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Spheno-orbital Lesions—A Major Review of Nonmeningioma Causes

McNab

Jones

Hardy

2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To review the imaging features of the broad range of nonmeningioma lesions of the greater wing of the sphenoid (GWS) bone and adjacent orbit to assist clinicians in differentiating these lesions from each other and from the most common lesion of the GWS and adjacent orbit, meningioma. Methods: We reviewed 32 cases of spheno-orbital lesions involving the GWS from our own practice, as well as 109 published cases (total 141), with emphasis on available imaging features on computerized tomography (CT) and MRI. Features that might assist in differentiating meningioma from its mimics were analyzed for each lesion, including the presence of an osteoblastic or hyperostotic response, bone erosion or osteolysis, homogeneous hypo- or hyperintensity on T2-weighted MRI, leptomeningeal involvement, and the absence of a “dural tail” on contrast-enhanced MRI. The clinical and imaging features were also briefly summarized for each diagnostic group. Results: The largest diagnostic group was metastasis (67 cases, 47.5%). The most useful imaging features that helped differentiate meningioma from its mimics were the presence of bone erosion and the absence of a “dural tail.” Other features were helpful in a small minority of cases only. Metastatic prostate cancer was the largest single group (21 cases), and 18 (85.7%) of these were osteoblastic and most closely mimicked meningioma. Prostate cancer patients were generally older than males with GWS meningioma. Almost all other (44/46, or 95.7%) metastatic lesions showed evidence of bone erosion. Almost half (30 of 61, 49.2%) of patients with metastasis presented without a known diagnosis of malignancy. Among children 16 years of age and less, Langerhans cell histiocytosis (10 cases), dermoid cyst (5), and Ewing’s sarcoma (5) were the most common diagnoses. Conclusions: A combination of a careful history and both CT and MRI gives information, which can best guide the management of patients with spheno-orbital lesions. Metastatic prostate cancer to the GWS most closely mimics GWS meningioma but can in most cases be differentiated on clinical and imaging features. Older males with hyperostotic lesions of the GWS should be investigated for prostate cancer. Other metastatic lesions and primary tumors of the GWS, as well as benign and structural lesions can readily be differentiated from meningioma on clinical and imaging features.

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Section: Resultsmentioning

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Spheno-orbital Lesions—A Major Review of Nonmeningioma Causes

McNab

Jones

Hardy

2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…EM has been reported in various cancers including lung, [ 14 ] pancreatic, [ 15 ] gastric, [ 16 ] pheochromocytoma, [ 17 ] upper gastrointestinal tract carcinoma, [ 18 ] neuroendocrine neoplasms, [ 19 ] breast, [ 20 ] renal carcinoma, [ 21 ] colorectal, [ 22 ] prostate, [ 23 ] and thyroid carcinoma [ 24 ] (Table 5 ).…”

Section: Discussionmentioning

confidence: 99%

CYFRA21-1/TG ratio as an accurate risk factor to predict eye metastasis in nasopharyngeal carcinoma

et al. 2020

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Nasopharyngeal carcinoma (NPC) has a distinctive geographical distribution in China, especially southern China. There are several risk factors for NPC, such as Epstein-Barr virus, genetics, and environmental exposures. Although the incidence of eye metastasis (EM) is lower than metastasis in other body parts, it often indicates poor prognosis. We assessed several serum biomarkers for their ability to predict EM in NPC. Patients with NPC were selected (n = 963), and were separated into two groups, EM and no eye metastasis. Ten factors were analyzed in both groups including triglyceride (TG), high-density lipoprotein, low-density lipoprotein, alkaline phosphatase, alpha fetoprotein, carbohydrate antigen-199, cancer antigen-153, apolipoproteins AI, apolipoprotein B, and cytokeratin fragment 19 (CYFRA21-1). Independent t tests, binary logistic regression, and receiver operating characteristic curves were used to assess the data. The EM group had significantly higher CYFRA21-1 and lower TG compared with the no eye metastasis group. Areas under the curve for CYFRA21-1, TG and CYFRA21-1/TG were 0.966, 0.771, and 0.976, respectively. The corresponding cut-off values were 12.12 ng/ml, 0.41 mmol/L, and 13.5. The sensitivity and specificity of CYFRA21-1/TG were 100% and 92.2%, respectively. The increased ratio of CYFRA21-1 to TG can be an accurate method to detect EM in patients with NPC.

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“…Prostate cancer (Pca) is a complicated disease that should be considered in the differential diagnosis of any disease in a man over 50 year old, regardless of his initial presentation. Pastore et al (1) recently published a case of Pca presented with ocular symptoms turned to be orbital metastasis. Mittal et al (2) described a patient that had bilateral orchiectomy for hormonal control of metastatic Pca where histology demonstrated metastatic Pca of the testis and epididymis.…”

Section: Introductionmentioning

confidence: 99%

Solitary prostatic cancer metastasis to the testis: A case report and lessons to learn

Ismail

Elmansy²,

Shahrour³

et al. 2020

Arch Ital Urol Androl

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Prostate cancer (Pca) is a complex disease. Several case series and reports have described the spread of Pca to unusual organs, like esophagus, eye and periureteric fat causing ureteropelvic junction obstruction. Spread of Pca to the testis has been reported in few case reports, however Pca was always firstly diagnosed in all published cases and testicular spread of cancer has been diagnosed during follow up of the patients. This case is unique in that, the patient initially presented with a testicular mass and histologic examination after orchiectomy allowed to diagnose prostatic cancer. This patient was 81 years old and he never had PSA screening by his family doctor. PSA was not even done initially by us considering his age and the presentation with testicular mass. This case may impact clinical practice in several ways: 1) considering Pca always in the differential diagnosis of any disease of an adult man, regardless of its presentation because we did not do that at initial patient evaluation and PSA was only measured after orchiectomy when pathology demonstrated metastatic Pca; 2) suggesting standard orchiectomy with epididemectomy for surgical castration instead of the current surgical technique of subcapsular/subepididymal orchiectomy, because our patient had cancer involving his epididymis as well; 3) suggesting to include PSMA as a part of preoperative staging for high risk Pca patients, in consideration that PSMA is proving to be a promising new imaging technique that can help diagnosing metastatic Pca in unusual locations.

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Orbital metastasis as presenting symptom from a prostatic adenocarcinoma

Cited by 4 publications

References 11 publications

Spheno-orbital Lesions—A Major Review of Nonmeningioma Causes

Spheno-orbital Lesions—A Major Review of Nonmeningioma Causes

CYFRA21-1/TG ratio as an accurate risk factor to predict eye metastasis in nasopharyngeal carcinoma

Solitary prostatic cancer metastasis to the testis: A case report and lessons to learn

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