Orbital metastasis mimicking internuclear ophthalmoplegia: A case report and review

Lin, Weijie; Chévez-Barrios, Patricia; Sadaka, Ama; Lee, Andrew G.

doi:10.1016/j.jcjo.2017.01.017

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…However, the tumors reported by Khawaja et al arose exclusively from colorectal adenocarcinomas and none of the cases were signet ring cell carcinomas. Orbital metastasis of other subtypes of colorectal carcinomas has also been observed [13][14][15]. Signet ring cell tumors are an uncommon tumor subtype comprising between 0.1% and 2.4% of all colorectal carcinomas [16].…”

Section: Discussionmentioning

confidence: 99%

Rare Signet Ring Cell Adenocarcinoma of the Colon Metastasis to the Orbit

Bacorn

Lin

2020

Case Reports in Ophthalmological Medicine

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Metastases arising from primary tumors of the gastrointestinal tract are not commonly encountered in the orbit. Colorectal carcinomas are subcategorized based on morphological and genetic characteristics with these distinctions bearing therapeutic and prognostic significance. The behavior of these subcategories, including their propensity for orbital metastasis, differs, and clinicians treating these tumors must be aware of their metastatic profiles. This report describes a 51-year-old female with right upper lid swelling and ptosis ultimately found, what we believe to be, the first reported case of signet ring cell colon carcinoma metastasizing to the levator muscle and superior orbit. This case serves as a reminder to all clinicians to consider orbital metastasis even in malignancies not typically found in this location.

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Section: Discussionmentioning

confidence: 99%

Rare Signet Ring Cell Adenocarcinoma of the Colon Metastasis to the Orbit

Bacorn

Lin

2020

Case Reports in Ophthalmological Medicine

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Colorectal carcinoma presenting in the orbit: mass effect from an uncommon cause

Long

Ediriwickrema

et al. 2020

Orbit

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Orbital Metastasis From Urothelial Carcinoma: A Comprehensive Literature Review

Sklar

Gervasio

Karmazin

et al. 2019

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To review the clinical features of orbital and choroidal metastases from urothelial carcinomas of the urinary tract among cases reported in the literature, and to describe a case of orbital metastasis from bladder cancer presenting as apparent internuclear ophthalmoplegia. Methods: Case reports of orbital and choroidal metastases from urothelial carcinomas published in the literature from 1965 to 2018 were reviewed. Data collected included patient demographics, cancer stage and primary site, time to onset of ocular symptoms, length of presenting ocular symptoms, types of primary ocular symptoms, diagnostic imaging, histology, systemic and ocular treatments, and survival time. Results: Twenty-eight cases of urothelial carcinoma with metastasis to the orbit or choroid were reviewed. Men were significantly more likely to suffer from this condition than women (p = 0.011). The average age of presentation with orbital symptoms was 63 years, with an average time of 19 months between primary cancer diagnosis and onset of orbital symptoms. Twenty-two patients had metastasis to the orbit and 6 to the choroid. In 4 cases, ocular deficits secondary to orbital and/or choroidal metastases were the initial presenting symptoms in patients with previously undiagnosed urothelial carcinoma. The most commonly noted primary ocular symptoms and signs consisted of decreased visual acuity, decreased ocular motility, proptosis, and diplopia. Average survival from onset of ocular symptoms was 4.67 months. Conclusions: Urothelial carcinoma may metastasize to the orbit or choroid; furthermore, its presentation may mimic internuclear ophthalmoplegia. It is recommended that any patient with visual symptoms and known urothelial cancer should undergo expedited workup for metastatic disease.

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Orbital metastasis mimicking internuclear ophthalmoplegia: A case report and review

Cited by 4 publications

References 12 publications

Rare Signet Ring Cell Adenocarcinoma of the Colon Metastasis to the Orbit

Rare Signet Ring Cell Adenocarcinoma of the Colon Metastasis to the Orbit

Colorectal carcinoma presenting in the orbit: mass effect from an uncommon cause

Orbital Metastasis From Urothelial Carcinoma: A Comprehensive Literature Review

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