Orbital plasmablastic lymphoma

Bloch, Edward; Robinson, Fiona

doi:10.1002/ccr3.1281

Cited by 3 publications

(2 citation statements)

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“…The most common presenting clinical signs and symptoms of orbital plasmablastic lymphoma in reported cases include eye pain, reduced vision, eyelid swelling, ophthalmoplegia, conjunctival chemosis, and globe proptosis (Table 1). Conjunctival chemosis and globe proptosis are the two most common clinical signs, with conjunctival chemosis present in 8 of the 13 total cases reported in the literature and proptosis reported in all of the cases 5–13 . We report a fifth case of an HIV-negative patient with ocular adnexal involvement of unilateral conjunctival chemosis and mild globe proptosis as initial presenting signs of plasmablastic lymphoma.…”

Section: Introductionmentioning

confidence: 84%

“…[4][5][6][7][8] The most common presenting clinical signs and symptoms of orbital plasmablastic lymphoma in reported cases include eye pain, reduced vision, eyelid swelling, ophthalmoplegia, conjunctival chemosis, and globe proptosis ( all of the cases. [5][6][7][8][9][10][11][12][13] We report a fifth case of an HIV-negative patient with ocular adnexal involvement of unilateral conjunctival chemosis and mild globe proptosis as initial presenting signs of plasmablastic lymphoma.…”

Section: Introductionmentioning

confidence: 92%

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Case Report: Conjunctival Chemosis as a Presenting Sign of Plasmablastic Lymphoma in a HIV Negative Patient

Mani

2023

Optom Vis Sci

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SIGNIFICANCE: Plasmablastic lymphoma (PBL) involving the ocular adnexa, although reported in the literature, is a rare clinical entity, especially when found in an immunocompetent patient. Understanding the clinical presentation can aid eye care practitioners in seeking timely diagnosis to avoid further delays in the treatment of this disease.PURPOSE: This study aimed to report orbital PBL in an HIV-negative patient and discuss the presenting clinical signs, symptoms, and other diagnostic findings for the proper treatment and management of this condition. CASE REPORT: A 79-year-old White male presented to our clinic for a second opinion for the evaluation of a swollen, mildly painful right eye for 2 months. The patient also complained of intermittent tenderness of the right frontal and paranasal sinuses. The initial diagnosis was preseptal cellulitis. Best-corrected visual acuity was 20/40 in the right eye and 20/30 in the left eye. A thorough comparison of the globe revealed subtle proptosis in the right eye. Slit-lamp evaluation revealed severe conjunctival chemosis, which was greatest in the inferotemporal quadrant, and diffuse right inferior eyelid edema. Globe proptosis was quantified via Luedde Exophthalmometer (Gulden Ophthalmics, Elkins Park, PA). Exophthalmometry values were 22 mm in the right eye and 20 mm in the left eye, suggesting mild proptosis of the right eye. MRI of the brain and orbits revealed an expansile lesion in the right maxillary, ethmoid, and paranasal sinuses. The mass also extended into the anterior cranial fossa and the right orbit. Needle biopsy and immunohistochemical analysis confirmed a diagnosis of PBL. The patient chose to discontinue chemotherapy owing to adverse systemic effects and died of the disease 36 months after the initial diagnosis. CONCLUSIONS: Unilateral conjunctival chemosis with no improvement or resolution warrants further investigation and workup. Eye care practitioners play a crucial role in the diagnosis and management of these patients in close collaboration with pathology, hematology, and oncology specialists.

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Section: Introductionmentioning

confidence: 84%