Orbital T-cell Lymphoma Human T-cell Leukemia Virus-I Infection

Unilateral conjunctival infiltration of Adult T-cell leukemia/lymphoma. Case report and literature review

“…Previous reports suggested that in cases of intraocular lymphoma, ATLL infiltration into the central nervous system is higher than in cases of ocular adnexal lymphoma. [8][9][10][11][12][13][14][15][16][17][18] In the present patient, mLSG15 therapy was not efficacious, and bulbar conjunctival lesions were observed during treatment for cytomegalovirus enteritis. Conjunctival biopsy revealed infiltration of atypical lymphocytes, although there was no evidence of cytomegalovirus infection.…”

“…Ophthalmological diseases caused by HTLV-1 infection encompass direct invasion of ATLL, [8][9][10][11][12][13][14][15][16][17][18] HTLV-1-related uveitis, 19 and cytomegalovirus retinitis, 13 as per the reports available to date. Conditions of ATLL infiltration into the eye are classified as ocular adnexal lymphoma and intraocular lymphoma.…”

“…[8][9][10][11][12][13][14] This may be due to the publication bias because ATLL is well-known to infiltrate extranodal organs. Table 1 shows the clinical manifestations in previous reports and our report.…”

“…Table 1 shows the clinical manifestations in previous reports and our report. The specific infiltration sites of ocular lesions were the orbit, 8 eyelid and conjunctiva, 9 eyelid, iris and orbit, 10 orbit and choroidal folds, 11 conjunctiva, 12 eyelid 13 and conjunctiva. 14 Four cases were bilateral infiltration 8,10,13,14 and three cases were unilateral infiltration.…”

“…7 Invasion of ATLL into extranodal organs, such as the skin, central nervous system, gastrointestinal tract, liver, and spleen, has been reported, 1 but ocular invasion is rarely reported. [8][9][10][11][12][13][14] We describe here a case of bulbar conjunctival infiltration during the course of acute type ATLL.…”