Orbitofrontal cortex abnormality and deficit schizophrenia

Kanahara, Nobuhisa; Sekine, Yoshimoto; Haraguchi, T.; Uchida, Yoshitaka; Hashimoto, Kenji; Shimizu, Eiji; Iyo, Masaomi

doi:10.1016/j.schres.2012.11.015

Cited by 79 publications

(42 citation statements)

References 40 publications

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“…Kanahara et al (2013) reported a prevalence of 45.2% for deficit syndrome in Japanese medicated patients, consistent with our study. Therefore, it is likely that ethnic heterogeneity (Asian vs. Caucasian) contributes to this difference in schizophrenia.…”

Section: Discussionsupporting

confidence: 92%

Impaired processing speed and attention in first-episode drug naive schizophrenia with deficit syndrome

Chen

Jiang

Zhong

et al. 2014

Schizophrenia Research

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Section: Discussionsupporting

confidence: 92%

Impaired processing speed and attention in first-episode drug naive schizophrenia with deficit syndrome

Chen

Jiang

Zhong

et al. 2014

Schizophrenia Research

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“…In a PET study performed during an effortful auditory discrimination task, Lahti et al [100] reported reduced rCBF in the right middle frontal cortex and in the right inferior parietal cortex in DS than in NDS subjects. However, in a recent SPECT study, Kanahara et al [103] failed to confirm that this pattern distinguishes DS from NDS, reporting that the orbitofrontal (OFC) was the only region with significant hypoperfusion in DS than in NDS subjects.…”

Section: Functional Neuroimaging Findingsmentioning

confidence: 97%

Neurobiological background of negative symptoms

Galderisi

Merlotti

Mucci

2015

Eur Arch Psychiatry Clin Neurosci

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Studies investigating neurobiological bases of negative symptoms of schizophrenia failed to provide consistent findings, possibly due to the heterogeneity of this psychopathological construct. We tried to review the findings published to date investigating neurobiological abnormalities after reducing the heterogeneity of the negative symptoms construct. The literature in electronic databases as well as citations and major articles are reviewed with respect to the phenomenology, pathology, genetics and neurobiology of schizophrenia. We searched PubMed with the keywords "negative symptoms," "deficit schizophrenia," "persistent negative symptoms," "neurotransmissions," "neuroimaging" and "genetic." Additional articles were identified by manually checking the reference lists of the relevant publications. Publications in English were considered, and unpublished studies, conference abstracts and poster presentations were not included. Structural and functional imaging studies addressed the issue of neurobiological background of negative symptoms from several perspectives (considering them as a unitary construct, focusing on primary and/or persistent negative symptoms and, more recently, clustering them into factors), but produced discrepant findings. The examined studies provided evidence suggesting that even primary and persistent negative symptoms include different psychopathological constructs, probably reflecting the dysfunction of different neurobiological substrates. Furthermore, they suggest that complex alterations in multiple neurotransmitter systems and genetic variants might influence the expression of negative symptoms in schizophrenia. On the whole, the reviewed findings, representing the distillation of a large body of disparate data, suggest that further deconstruction of negative symptomatology into more elementary components is needed to gain insight into underlying neurobiological mechanisms.

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“…More recently, single photon emission tomography studies showed reduced cerebral blood flow in SZD with respect to SZND in frontal (Gonul et al, 2003;Kanahara et al, 2013) and bilateral frontodorsolateral (Vaiva et al, 2002) cortices. Moreover, using magnetic Contents lists available at ScienceDirect journal homepage: www.elsevier.com/locate/psychresns resonance spectroscopy, Delamillieure and colleagues interpreted a reduced concentration of N-acetyl aspartate in the medial prefrontal cortex of SZD as an indicator of neuronal impairment in that region (Delamillieure et al, 2000).…”

Section: Introductionmentioning

confidence: 98%