ORChestra coordinates the replication and repair music

Abstract

Error-free genome duplication and accurate cell division are critical for cell survival. In all three domains of life, bacteria, archaea, and eukaryotes, initiator proteins bind replication origins in an ATP-dependent manner, play critical roles in replisome assembly, and coordinate cell-cycle regulation. We discuss how the eukaryotic initiator, Origin recognition complex (ORC), coordinates different events during the cell cycle. We propose that ORC is the maestro driving the orchestra to coordinately perform the musical pieces of replication, chromatin organization, and repair.

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“…The leucine-rich repeats and WD repeat domain containing 1 ( lrwd1 ) is presumed to be the part of origin recognition complex (ORC). ORC is responsible for the initiation of DNA replication and DNA repair (Shen et al 2010; Vermeulen et al 2010; Liu et al 2023).…”

“…The leucine-rich repeats and WD repeat domain containing 1 (lrwd1) is presumed to be the part of origin recognition complex (ORC). ORC is responsible for initiation of DNA replication and DNA repair (Shen et al 2010;Vermeulen et al 2010;Liu et al 2023). The final gene in this group, RAD51 paralog D (rad51d), is member of the RAD51 recombinases that are highly conserved across species (Lin et al 2006;Greenhough et al 2023).…”