Orchestrating Lymphocyte Polarity in Cognate Immune Cell–Cell Interactions

Bustos‐Morán, Eugenio; Blas‐Rus, Noelia; Martín-Cófreces, Noa B.; Sánchez-Madrid, Francisco

doi:10.1016/bs.ircmb.2016.06.004

Cited by 25 publications

(19 citation statements)

References 276 publications

(389 reference statements)

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“…APCs are able to present antigens to cognate naïve CD4+ and CD8+ T cells [ 185 ]. Upon antigen recognition, CD4+ T cells activate, proliferate, and differentiate into specialized effector T helper (Th) cells, whereas CD8+ T cells activate, proliferate, and differentiate into CD8+ cytotoxic T lymphocytes (CTL) [ 186 , 187 ].…”

Section: Lamin A/c In Adaptive Immunitymentioning

confidence: 99%

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Lamin A/C and the Immune System: One Intermediate Filament, Many Faces

Saéz

Herrero‐Fernández

Gómez-Bris

et al. 2020

IJMS

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Nuclear envelope lamin A/C proteins are a major component of the mammalian nuclear lamina, a dense fibrous protein meshwork located in the nuclear interior. Lamin A/C proteins regulate nuclear mechanics and structure and control cellular signaling, gene transcription, epigenetic regulation, cell cycle progression, cell differentiation, and cell migration. The immune system is composed of the innate and adaptive branches. Innate immunity is mediated by myeloid cells such as neutrophils, macrophages, and dendritic cells. These cells produce a rapid and nonspecific response through phagocytosis, cytokine production, and complement activation, as well as activating adaptive immunity. Specific adaptive immunity is activated by antigen presentation by antigen presenting cells (APCs) and the cytokine microenvironment, and is mainly mediated by the cellular functions of T cells and the production of antibodies by B cells. Unlike most cell types, immune cells regulate their lamin A/C protein expression relatively rapidly to exert their functions, with expression increasing in macrophages, reducing in neutrophils, and increasing transiently in T cells. In this review, we discuss and summarize studies that have addressed the role played by lamin A/C in the functions of innate and adaptive immune cells in the context of human inflammatory and autoimmune diseases, pathogen infections, and cancer.

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Section: Lamin A/c In Adaptive Immunitymentioning

confidence: 99%

“…T cell activation also necessitates the movement of the microtubule organizing center (MTOC) towards the T cell-APC contact site. The relocated MTOC then guides the polarization of intracellular vesicles to the IS [ 185 ].…”

Section: Lamin A/c In Adaptive Immunitymentioning

confidence: 99%

Lamin A/C and the Immune System: One Intermediate Filament, Many Faces

Saéz

Herrero‐Fernández

Gómez-Bris

et al. 2020

IJMS

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“…The orchestration of signaling by surface receptors as well as signaling molecules that accumulate at the IS area crucially depends on the polarization of the microtubule-organizing center (MTOC) 19 , which brings the endosomal recycling compartment at the T cell:APC contact region, thus favoring directional intracellular trafficking 20 . In naïve T cells, a number of molecules, including receptors (for example, the TCR) and membrane-associated regulators—for example, the lymphocyte-specific protein tyrosine kinase (Lck) and the linker for activation of T cells (LAT)—are clustered to the synaptic area not only from plasma membrane-associated pools but also from intracellular endosomal pools 2 .…”

Section: Vesicular Trafficking At the Immunological Synapsementioning

confidence: 99%

Transcellular communication at the immunological synapse: a vesicular traffic-mediated mutual exchange

2017

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The cell’s ability to communicate with the extracellular environment, with other cells, and with itself is a crucial feature of eukaryotic organisms. In the immune system, T lymphocytes assemble a specialized structure upon contact with antigen-presenting cells bearing a peptide-major histocompatibility complex ligand, known as the immunological synapse (IS). The IS has been extensively characterized as a signaling platform essential for T-cell activation. Moreover, emerging evidence identifies the IS as a device for vesicular traffic-mediated cell-to-cell communication as well as an active release site of soluble molecules. Here, we will review recent advances in the role of vesicular trafficking in IS assembly and focused secretion of microvesicles at the synaptic area in naïve T cells and discuss the role of the IS in transcellular communication.

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“…LAT associates with SLP76 that recruits multimolecular complexes. PLCc1 being one of the multimolecular complexes ligates with LAT and induces activation of PLCc1Á Activated PLCc1 then reacts with phosphatidylinositol-4,5-bisphosphate at the plasma membrane generating diacylglycerol (DAG) and inositol-1,4,5-trisphosphate (IP3) (Bustos-Mor an et al 2016). This IP3 then ligates with the IP3 receptor (IP3R) on endoplasmic reticulum (ER), thereby releasing Ca 2+ from ER.…”

Section: Introductionmentioning

confidence: 99%

T11TS immunotherapy potentiates the repressed calcineurin‐NFAT signalling pathway of T cells in Cryptococcus neoformans infected rats: a cue towards T‐cell activation for antifungal immunity

Faruk

Hazra²,

Mondal³

et al. 2020

J Appl Microbiol

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Aims: To examine the modulation of the interacting partners of the calcineurin (CaN)-NFAT pathway in T cells during Cryptococcus neoformans fungal infection and post-T11TS immunotherapy. Methods and Results: Wistar rats were infected with C. neoformans and followed by immunotherapy with immune-potentiator T11TS. T cells were analysed by flow cytometry, immunoblotting and nuclear translocation study. The signalling proteins LCK, FYN, LAT, PLCc1 and CaN in T cells were regulated by C. neoformans infection resulting in reduced nuclear translocation of NFAT and IL-2 expression. Following T11TS immunotherapy, the expressions of the above-mentioned proteins were boosted and thus resulting in the clearance of C. neoformans from lung and spleen. Conclusions: The precise mechanism of suppression of the T-cell function by C. neoformans is still unknown. Previously, we have shown that T11TS positively regulates the function of T cells to abrogate glioma and other immunosuppressive conditions. T11TS immunotherapy increased the expression of the above signalling partners of the CaN-NFAT pathway in T cells and improved nuclear retention of NFAT. As a result, an increased IL-2 expression leads to activation and proliferation of T cells. Significance and Impact of the Study: Our results demonstrate the role of T11TS in restoring the CaN-NFAT signalling pathway in T cells. It identifies T11TS as an immunotherapeutic agent with potential clinical outcomes to counteract C. neoformans infection.

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Orchestrating Lymphocyte Polarity in Cognate Immune Cell–Cell Interactions

Cited by 25 publications

References 276 publications

Lamin A/C and the Immune System: One Intermediate Filament, Many Faces

Lamin A/C and the Immune System: One Intermediate Filament, Many Faces

Transcellular communication at the immunological synapse: a vesicular traffic-mediated mutual exchange

T11TS immunotherapy potentiates the repressed calcineurin‐NFAT signalling pathway of T cells in Cryptococcus neoformans infected rats: a cue towards T‐cell activation for antifungal immunity

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