Orchestration of Obesolytic Activity of Microbiome: Metabiotics at Centre Stage

Abstract

Metabiotics have emerged as the safer alternatives to probiotics in last one decade. Unlike probiotics that are live microbes, metabiotics are the low molecular weight bioactive metabolites produced by the gut microbiota. While offering a similar profile of health benefits as that of probiotics, metabiotics are free from the risks and uncertain responses associated with administration of live bacteria into the body. Metabiotics have demonstrated substantial effectiveness across the ethnicities, age, gender and nutritional habits in a number of metabolic disorders including obesity. Obesity is attributed to the offsetting of the energy homeostasis of the body due to a number of genetic, endocrinological, and environmental factors leading to obesity. The obesogenic mechanisms are quite complicated as they result from a complex interplay among a number of factors. Owing to a variety of constituents exerting their action through different pathways, metabiotics offer a pragmatic option for treatment as well as prevention of obesity by addressing heterogeneous aspects of its aetiology. In this review, we categorize various components of metabiotics and discuss their cross-talk with host cells at molecular level. We also discuss the challenges in understanding these interactions and their potential effects on obesity treatment and prevention strategies. Considering the alarming rise in obesity all over the world, metabiotics offer an attractive non-pharmacological approach to spearhead the strategies being designed to combat the challenges posed by the obesity epidemic

Перспективи Використання Пробіотиків Якмодуляторів Кишкової Мікробіоти При Ожирінні (Оглядлітератури)

“…До сим біотиків дуже близькі синбіотики (від syn biosσυν βίος, взаємне посилення ефекту дії), які поєднують в одному препараті ПРоБ і ПРеБ, стимулюють ріст і метаболічну активність нормальної Мб [15,16]. Останнім часом з'явились постбіотики, парабіотики, метабіотики [17], мультистрейнові пробіотичні препарати, що підкреслює різноманіття їх ефектів. Останніми роками асортимент ПРоБ помітно розширився, зараз відомо понад 60 препаратів.…”

A Narrative Review on the Advance of Probiotics to Metabiotics

“…These interactions are closely associated with host microbiota activity [ 9 ]. The representative components of metabiotics are short-chain fatty acids (SCFAs), polyunsaturated fatty acids (PUFAs), bacteriocins, polysaccharides, and peptides [ 10 ].…”