Orchiepididymitis in a Boy With COVID-19

Gagliardi, Luigi; Bertacca, Carlo; Centenari, Chiara; Merusi, Ilaria; Parolo, Eva; Ragazzo, Vincenzo; Tarabella, Vittorio

doi:10.1097/inf.0000000000002769

Cited by 71 publications

(66 citation statements)

References 5 publications

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“…The third one was a lethal case in a 43-year-old man [45]. Another case was a diagnosis of orchi-epididymitis in a 14-year-old boy with concurrent COVID-19 infection [46].…”

Section: Covid-19 and Gonadal Pathologymentioning

confidence: 99%

A comprehensive review of the impact of COVID-19 on human reproductive biology, assisted reproduction care and pregnancy: a Canadian perspective

2020

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Currently, the world is in the seventh month of the COVID-19 pandemic. Globally, infections with novel SARS-CoV-2 virus are continuously rising with mounting numbers of deaths. International and local public health responses, almost in synchrony, imposed restrictions to minimize spread of the virus, overload of health system capacity, and deficit of personal protective equipment (PPE). Although in most cases the symptoms are mild or absent, SARS-CoV-2 infection can lead to serious acute respiratory disease and multisystem failure. The research community responded to this new disease with a high level of transparency and data sharing; with the aim to better understand the origin, pathophysiology, epidemiology and clinical manifestations. The ultimate goal of this research is to develop vaccines for prevention, mitigation strategies, as well as potential therapeutics.The aim of this review is to summarize current knowledge regarding the novel SARS CoV-2, including its pathophysiology and epidemiology, as well as, what is known about the potential impact of COVID-19 on reproduction, fertility care, pregnancy and neonatal outcome. This summary also evaluates the effects of this pandemic on reproductive care and research, from Canadian perspective, and discusses future implications.In summary, reported data on pregnant women is limited, suggesting that COVID-19 symptoms and severity of the disease during pregnancy are similar to those in non-pregnant women, with pregnancy outcomes closely related to severity of maternal disease. Evidence of SARS-CoV-2 effects on gametes is limited. Human reproduction societies have issued guidelines for practice during COVID-19 pandemic that include implementation of mitigation practices and infection control protocols in fertility care units. In Canada, imposed restrictions at the beginning of the pandemic were successful in containing spread of the infection, allowing for eventual resumption of assisted reproductive treatments under new guidelines for practice. Canada dedicated funds to support COVID-19 research including a surveillance study to monitor outcomes of COVID-19 during pregnancy and assisted reproduction. Continuous evaluation of new evidence must be in place to carefully adjust recommendations on patient management during assisted reproductive technologies (ART) and in pregnancy.

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“…The third one was a lethal case in a 43-year-old man [45]. Another case was a diagnosis of orchi-epididymitis in a 14-year-old boy with concurrent COVID-19 infection [46].…”

Section: Covid-19 and Gonadal Pathologymentioning

confidence: 99%

A comprehensive review of the impact of COVID-19 on human reproductive biology, assisted reproduction care and pregnancy: a Canadian perspective

2020

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“…The relationship between testicular pain and COVID‐19 is one of the least informed subjects among the existing urological diseases. In the current literature, only one case report was published regarding COVID‐19‐related scrotal or testicular pain 15,16 . In this study, we aimed to evaluate COVID‐19‐related testicular pain in hospitalised patients because of COVID‐19 and to review as an aetiological factor for epididymo‐orchitis.…”

Section: Introductionmentioning

confidence: 99%

Is there any association of COVID‐19 with testicular pain and epididymo‐orchitis?

Ediz¹,

Tavukçu²,

Akan³

et al. 2020

Int J Clin Pract

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Aims This study aims to analyse the novel Coronavirus disease‐ (COVID‐19) related testicular pain in hospitalised patients because of COVID‐19 and to review as an aetiological factor for epididymitis, orchitis or both. Methods A total of 91 patients were included in the study. A questionnaire was formed for the questioning of testicular pain or epididymo‐orchitis in patients with COVID‐19. Demographics and past medical history was also recorded. Patients’ neutrophil and lymphocyte counts, neutrophil‐lymphocyte ratios (NLR), C‐reactive protein (CRP) levels and D‐dimer values were recorded. Patients with COVID‐19 were divided into two groups according to absence or presence of testicular pain or epididymo‐orchitis as group 1 and group 2. All results were compared for both groups. Results The median age of patients was similar in both groups. Testicular pain was occurred in 10.98% of the patients. Clinical presentation of epididymo‐orchitis was diagnosed in only one patient. No statistically significant difference was reported in terms of patients’ age, levels of CRP and D‐Dimer or NLR and results of questionnaire form queries between the two groups (P > .05). Conclusion Testicular pain was observed more frequently in hospitalised COVID‐19 cases. While no inflammation marker which is related to predict of testicular pain or epididymo‐orchitis was found in patients with COVID‐19.

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“…Furthermore, a previous study has shown that testicular damage, orchitis and sterility are possible complications of SARS-CoV (Xu et al, 2006). Recently, a case report study showed that orchiepididymitis in a 14-year-old boy seemed to be a complication of COVID-19 (Gagliardi et al, 2020). Notably, higher expression of ACE2 in male gonads seems to be associated with younger age and, as a result, provides evidence that younger patients are more vulnerable to gonadal involvement by SARS-CoV-2 (Shen et al, 2020).…”

mentioning

confidence: 99%

Potential mechanisms of SARS‐CoV‐2 action on male gonadal function and fertility: Current status and future prospects

et al. 2020

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Since the first emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as novel coronavirus (2019-nCoV), in Wuhan, China, in December 2019 (Tan et al., 2020), the virus has spread rapidly worldwide and, therefore, has been officially declared a pandemic outbreak with more than 10 million confirmed cases and 499,000 deaths according to the WHO report (Situation Report, 2020). Pneumonia with fever seems to be the most common presentation of SARS-CoV-2 infection (Guan et al., 2020; Wang, Hu et al., 2020). SARS-CoV-2 was also detected in specimens of faeces and a small percentage of blood and urine

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Orchiepididymitis in a Boy With COVID-19

Cited by 71 publications

References 5 publications

A comprehensive review of the impact of COVID-19 on human reproductive biology, assisted reproduction care and pregnancy: a Canadian perspective

A comprehensive review of the impact of COVID-19 on human reproductive biology, assisted reproduction care and pregnancy: a Canadian perspective

Is there any association of COVID‐19 with testicular pain and epididymo‐orchitis?

Potential mechanisms of SARS‐CoV‐2 action on male gonadal function and fertility: Current status and future prospects

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