Order from Disorder: The Intrinsically Disordered Protein Tau Facilitates Higher-Order Assembly of Microtubules

Abstract

filamentous structure at the very tip of sidearm as a newly named ''antenna'', which is comprised of two anti-parallel coiled-coil structures and crucial for dynein-binding. Furthermore, the composition of the globular head which is important for microtubule-binding is also renewed as the complex of the two discontinuous regions. These findings provide the clues for understanding dynactin functions and its molecular mechanism, especially as a regulator of dynein.