Ordered Mesoporous Silica Material SBA-15: A Broad-Spectrum Formulation Platform for Poorly Soluble Drugs

Speybroeck, Michiel Van; Barillaro, Valery; Thi, Thao Do; Mellaerts, Randy; Martens, Johan A.; Humbeeck, Jan Van; Vermant, Jan; Annaert, Pieter; Mooter, Guy Van den; Augustijns, Patrick

doi:10.1002/jps.21638

Cited by 251 publications

(149 citation statements)

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“…MSNs are synthesized at both acidic and basic pH with different pore structures. For example, lamellar meso phases are synthesized at high pH (>12), while hexagonal structures are produced at basic pH (10)(11)(12) [20].…”

Section: Pore Sizementioning

confidence: 99%

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Mesoporous Silica Nanoparticles: A Review

Mehmood¹,

Ghafar²,

Yaqoob³

et al. 2017

J Dev Drugs

133

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Section: Pore Sizementioning

confidence: 99%

“…Mesoporous silica materials are considering excellent carriers for drug delivery because of their textural properties which increase the loading amount of drug inside the pore channels. Similarly, drug diffusion kinetics can be controlled due to the functionalization of silanol group [11,12].…”

Section: Introductionmentioning

confidence: 99%

Mesoporous Silica Nanoparticles: A Review

Mehmood¹,

Ghafar²,

Yaqoob³

et al. 2017

J Dev Drugs

133

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“…However, these silicate glasses have disordered pore networks, and their structure, morphology, surface area, pore size and volume are not adjustable as is the case of ordered mesoporous silicates. Currently, the commonly accepted opinion is that the release of drugs from mesoporous silicates depends on the pore architecture (23) and pore diameter (24), specific drug-silicate pore wall interactions (25) and the physical state of the incorporated drug (11). Drug release is generally controlled by diffusion because the silica matrix remains unchanged during drug release and so the release kinetics can be described with Fick's laws.…”

Section: Controlled Drug Release From Ordered Mesoporous Matricesmentioning

confidence: 99%

“…In the literature there are only a few studies of the actual physical state of drugs confined in mesoscopic dimensions, which are mostly limited to very specific examples (26,29), whereas general knowledge about the physical form of the drug incorporated into mesopores and about the mechanism of drug release and its relation to structural properties of the mesoporous framework are still missing. One can even find examples where the release studies of structurally very similar molecules from equivalent mesoporous carriers lead to equal drug-release profiles, which are explained by entirely different or even opposing mechanisms (11,26). The model most commonly used to describe the kinetics of drug release is the Korsmeyer-Peppas (power law) model (30), which is successfully fitted to experimental results but does not give any information about the underlying mechanism of drug release.…”

Section: Controlled Drug Release From Ordered Mesoporous Matricesmentioning

confidence: 99%

“…Since the number of poorly soluble drug candidates has risen sharply over the last two decades, enhancement of drug dissolution became an important task as well. It was demonstrated that mesoporous materials represent a great potential to overcome this problem (9)(10)(11). Herein we will describe mesoporous materials, specifically silicates, such as MCM-41 and SBA-15 (1)(2)(3).…”

mentioning

confidence: 99%

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Ordered mesoporous silicates as matrices for controlled release of drugs

Ukmar

Planinšek

2010

Acta Pharmaceutica

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According to the International Union of Pure and Applied Chemistry (IUPAC), porous materials are classified into three categories: microporous with pore diameters less than 2 nm, mesoporous having pore diameters between 2 and 50 nm, and macroporous with pore sizes larger than 50 nm. Highly ordered mesoporous silicates such as MCM (Mobil Composition of Matter No. 41, 48,...) and SBA (Santa Barbara Amorphous material No. 1, 3, 15,...) have been long recognized as very promising materials with a rich variety of possible applications (1). The various types of MCM and SBA silicates can be distinguished by the number after the acronym. The three most important MCM materials are: MCM-41 (hexagonal), MCM-48 (cubic) and MCM-50 (lamellar). Also a wide variety of SBA materials has been prepared, such as SBA-1 (cubic), SBA-11 (cubic), SBA-12 (3D hexagonal network), SBA-14 (lamellar), SBA-15 (2D hexagonal) and SBA-16 (cubic cage-structured). They show ordered arrangements of channels and cavities of different geometry confined between walls built up from SiO 2 units. Among all numerous applications of mesoporous materials, ranging from separation technology, catalysis, hydrogen Interest in and thereby also development of ordered mesoporous silicates as drug delivery devices have grown immensely over the past few years. On hand selected cases from the literature, the power of such systems as delivery devices has been established. Specifically, it is shown how it is possible to enhance the release kinetics of poorly soluble drugs by embedding them in mesoporous silicates. Further critical factors governing the structure and release of the model drug itraconazole incorporated in an SBA-15 matrix are briefly reviewed. The possibility of functionalizing the surface of mesoporous matrices also under harsher conditions offers a broad platform for the design of stimuli-responsive drug release, including pH responsive systems and systems which respond to the presence of specific ions, reducing agents, magnetic field or UV light, whose efficiency and biocompatibility has been established in vitro.

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