Ordered mesoporous silica nanocarriers: An innovative paradigm and a promising therapeutic efficient carrier for delivery of drugs

Patel, Ravish J.; Pandey, Punit; Patel, Amit A.; Prajapati, Bhupendra G.; Alexander, Amit; Pandya, Vidhi; Trivedi, Nidhi; Shah, Shailvi; Patel, Viral

doi:10.1016/j.jddst.2023.104306

Cited by 9 publications

(5 citation statements)

References 142 publications

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“…The last mode, known as tone enhancement, involves limiting the red wavelength, thereby improving the visualization of subtle irregularities and the vascular structure within the mucosa. According to Cho and his colleagues, tone enhancement proves to be an effective tool for characterizing previously identified lesions [29,33,34]. In a clinical research, Hoffman and collaborators evaluated the efficacy of i-scan versus conventional colonoscopy.…”

Section: I-scan Digital Contrastmentioning

confidence: 99%

The Evolving Landscape of Colonoscopy: Recent Developments and Complication Management

Patel,

Momin

et al. 2024

Colonoscopy - Diagnostic and Therapeutic Advances

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Colorectal cancer is globally recognized as the third most prevalent cancer, highlighting the crucial role of colonoscopy in diagnosis and therapeutic interventions. This medical procedure has demonstrated its effectiveness in preventing colorectal cancer and investigating a wide range of gastrointestinal symptoms. It has long been acknowledged as the gold standard for screening colorectal cancer. The primary objective of this analysis is to outline diverse range of complications associated with preparatory phase of colonoscopy, especially among hospitalized patients, including those with potentially life-threatening conditions. The ultimate aim is to elucidate strategies to prevent complications during the preparatory phase of colonoscopy. The real-time visual feed produced by endoscopic camera allows for the detection of abnormal growth of the colonic wall. This capability facilitates the assessment, biopsy, and removal of mucosal lesions through various biopsy instruments accessible via specialized channels. With its multifaceted utility, colonoscopy has become a frontline approach in making colorectal cancer a preventable and early-detectable disease over the past few decades. Common complications associated with colonoscopy include occurrences like vomiting, nosebleeds, abdominal pain, and acute diarrhoea. This review primarily focuses on developments that have transpired over the past five years, leading to changes in multiple aspects of colonoscopy.

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Section: I-scan Digital Contrastmentioning

confidence: 99%

The Evolving Landscape of Colonoscopy: Recent Developments and Complication Management

Patel,

Momin

et al. 2024

Colonoscopy - Diagnostic and Therapeutic Advances

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“…This unique configuration of MSNs holds several advantages, including significant surface area, large pore volume, pore diameter, chemical and thermal stability, biocompatibility, and biodegradability. The exceptional properties of MSNs make them an attractive candidate for diverse fields, including drug delivery, catalysis, and biomedical applications [ 38 , 39 ].…”

Section: Mesoporous Silica Nanoparticles (Msns)mentioning

confidence: 99%

“…an attractive candidate for diverse fields, including drug delivery, catalysis, and biomedical applications [38,39].…”

Section: Types Of Msnsmentioning

confidence: 99%

Mesoporous Silica Nanoparticles: Types, Synthesis, Role in the Treatment of Alzheimer’s Disease, and Other Applications

Sivamaruthi,

Kapoor,

Kukkar

et al. 2023

Pharmaceutics

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Globally, many individuals struggle with Alzheimer’s disease (AD), an unrelenting and incapacitating neurodegenerative condition. Despite notable research endeavors, effective remedies for AD remain constrained, prompting the exploration of innovative therapeutic avenues. Within this context, silica-based nanoplatforms have emerged with pronounced potential due to their unique attributes like expansive surface area, customizable pore dimensions, and compatibility with living systems. These nanoplatforms hold promise as prospective interventions for AD. This assessment provides a comprehensive overview encompassing various forms of mesoporous silica nanoparticles (MSNs), techniques for formulation, and their applications in biomedicine. A significant feature lies in their ability to precisely guide and control the transport of therapeutic agents to the brain, facilitated by the adaptability of these nanoplatforms as drug carriers. Their utility as tools for early detection and monitoring of AD is investigated. Challenges and prospects associated with harnessing MSNs are studied, underscoring the imperative of stringent safety evaluations and optimization of how they interact with the body. Additionally, the incorporation of multifunctional attributes like imaging and targeting components is emphasized to enhance their efficacy within the intricate milieu of AD. As the battle against the profound repercussions of AD persists, MSNs emerge as a promising avenue with the potential to propel the development of viable therapeutic interventions.

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“…The polymer prepared by traditional ion imprinting technology has the disadvantages of too deep embedding of imprinted sites, di cult elution, and easy agglomeration, etc., and the surface imprinting technology solves this problem [23,24]. Ordered mesoporous silica has the advantages of a large speci c surface area, large pore volume, adjustable pore size, low toxicity, good biocompatibility, and good chemical stability [25][26][27]. Therefore, it is often selected as a carrier in composite materials [28,29].…”

Section: Introductionmentioning

confidence: 99%

Novel Electrochemical Sensor based on rGO@TiO2 Composite Material and Ion-Imprinted Polymer Modification for Highly Selective Detection of Cadmium Ions in Real Samples

Zhang,

Liu,

Huang

et al. 2023

Preprint

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Cd(II) has extensive applications in various industries such as electronics, batteries, and coatings, but it is also known as a highly hazardous pollutant. An electrochemical sensor based on ion-imprinted polymers (IIPs) and reduced graphene oxide-titanium oxide (rGO@TiO2) was prepared for the selective sensitive determination of Cd(II) in real samples. The IIPs were prepared using modified SiO2 as the carrier by surface imprinting technology, which increased the imprinting sites of the polymer and made template ions easy to eluate and improved the electron transfer rate and separation efficiency. The Cd(II) ion-imprinted electrochemical sensor was constructed by mixing IIPs with rGO@TiO2 in proportion. The morphologies of the imprinted composites were characterized by TEM, FT-IR, and XRD. The electrochemical behavior of imprinted polymers was characterized by CV, DPV, and EIS. The results demonstrated that the sensor has good selectivity for target Cd(II). Under optimized experimental conditions, the electrochemical sensor showed a good linear relationship in the range of 10− 8 ~ 10− 5 mol L-1, and the lowest detection limit was 1.2×10− 8 mol L-1. The sensor had excellent repeatability and stability in addition to high sensitivity and strong selectivity. Finally, the electrochemical sensor has been successfully applied to the determination of trace Cd(II) in practical samples.

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Ordered mesoporous silica nanocarriers: An innovative paradigm and a promising therapeutic efficient carrier for delivery of drugs

Cited by 9 publications

References 142 publications

The Evolving Landscape of Colonoscopy: Recent Developments and Complication Management

The Evolving Landscape of Colonoscopy: Recent Developments and Complication Management

Mesoporous Silica Nanoparticles: Types, Synthesis, Role in the Treatment of Alzheimer’s Disease, and Other Applications

Novel Electrochemical Sensor based on rGO@TiO2 Composite Material and Ion-Imprinted Polymer Modification for Highly Selective Detection of Cadmium Ions in Real Samples

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