ORE9, an F-Box Protein That Regulates Leaf Senescence in Arabidopsis

Woo, Hye Ryun; Chung, Kyung Min; Park, Joon‐Hyun; Oh, Sung Aeong; Ahn, Tae-Jin; Hong, Sung Hyum; Jang, Sung Key; Nam, Hong Gil

doi:10.2307/3871318

Cited by 47 publications

(70 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4B). Despite conservation of the F-box motif, presence of similar C-terminal LRRs, and similar intron͞exon positions, genetic analysis indicates that the corresponding proteins are functionally distinct (8,9,14,15).…”

Section: Resultsmentioning

confidence: 99%

“…Multiple LRRs assemble together to form an arched docking structure (29). Forty-two of the F-box proteins, including TIR1, COI, and ORE9͞MAX2 (8,9,14,15), matched one of the LRR consensus sequences in the SMART database. An additional 160 proteins were found to contain a plant-specific derivative of the cysteine-containing LRR (designated here LRR PD).…”

Section: Resultsmentioning

confidence: 99%

“…This diversity is also supported by genetic analysis of the C3 subgroup genes TIR1, COI1, and ORE9͞ MAX2. The phenotypes of mutants in these genes suggest that the wild-type proteins have unique functions even though they have similar F-box motifs and C-terminal domains (8,9,14,15).…”

Section: Discussionmentioning

confidence: 99%

“…ASK1, one of the 19 Skp proteins in Arabidopsis (5), is involved in male gametogenesis and floral organ identity (6,7). Arabidopsis F-box (FBX) genes have been implicated in auxin (TIR1) and jasmonate signaling (COI1) (8,9), floral homeosis (UFO) (10), flowering time and circadian clocks (ZTL͞FKF͞LKP2) (11)(12)(13), leaf senescence and lateral shoot branching (ORE1͞MAX2) (14,15), and photomorphogenesis (EID1) (16). Cursory searches of the Arabidopsis genome detected many other FBX loci, suggesting that they comprise a large gene family (17,18).…”

mentioning

confidence: 99%

See 3 more Smart Citations

The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis

Gagne

Downes²,

Shiu³

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

604

648

View full text Add to dashboard Cite

The covalent attachment of ubiquitin is an important determinant for selective protein degradation by the 26S proteasome in plants and animals. The specificity of ubiquitination is often controlled by ubiquitin-protein ligases (or E3s), which facilitate the transfer of ubiquitin to appropriate targets. One ligase type, the SCF E3s are composed of four proteins, cullin1͞Cdc53, Rbx1͞Roc1͞Hrt1, Skp1, and an F-box protein. The F-box protein, which identifies the targets, binds to the Skp1 component of the complex through a degenerate N-terminal Ϸ60-aa motif called the F-box. Using published F-boxes as queries, we have identified 694 potential F-box genes in Arabidopsis, making this gene superfamily one of the largest currently known in plants. Most of the encoded proteins contain interaction domains C-terminal to the F-box that presumably participate in substrate recognition. The F-box proteins can be classified via a phylogenetic approach into five major families, which can be further organized into multiple subfamilies. Sequence diversity within the subfamilies suggests that many F-box proteins have distinct functions and͞or substrates. Representatives of all of the major families interact in yeast two-hybrid experiments with members of the Arabidopsis Skp family supporting their classification as F-box proteins. For some, a limited preference for Skps was observed, suggesting that a hierarchical organization of SCF complexes exists defined by distinct Skp͞F-box protein pairs. Collectively, the data shows that Arabidopsis has exploited the SCF complex and the ubiquitin͞26S proteasome pathway as a major route for cellular regulation and that a diverse array of SCF targets is likely present in plants.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis

Gagne

Downes²,

Shiu³

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

604

648

View full text Add to dashboard Cite

show abstract

“…Recientemente, Gagne et al, (2002) identificaron 694 posibles genes Fbox en A. thaliana, haciendo de este gen una superfamilia, aunque sólo en pocos casos se ha demostrado un papel para el complejo SFC (Gray et al, 1999;Samach et al, 1999;Dieterle et al, 2001;Woo et al, 2001;.…”

unclassified

Análisis funcional del gen Ep5C y su implicación en los mecanismos de defensa en plantas

González¹

View full text Add to dashboard Cite

AgradecimientosDurante todos estos años de trabajo en el laboratorio, he tenido la oportunidad de conocer y compartir con un número grande de personas a las cuales desearía agradecerles todo el apoyo que me han brindado desde mi llegada a este país y principalmente al IBMCP y sobre todo a quienes han contribuido a la culminación exitosa de este trabajo de investigación.Sin lugar a dudas, a quien más debo agradecer es a mi director de tesis, el Doctor Pablo Vera por haberme dado la oportunidad de trabajar en su grupo y sobre todo por ser no solo un jefe, sino por darme también su apoyo en todos los momentos.No podría dejar de mencionar en este momento a Esther Mayda, José Gadea, Enric Bellés, Lucia Jordá, Gema Ancillo, Concha Domingo, Dolores, Mireia Bordás, Mari Carmen Marquez, María Emilia Medina, Helena Olivares, Joaquin Fayos, Ismael Rodrigo, José María Bellés, Mónica Diez, Susana quienes desde un inicio me brindaron todo su apoyo y compañerismo tanto dentro como fuera del laboratorio y sin los cuales mi proceso de adaptación a este país hubiera resultado más difícil.Merece un agradecimiento especial, mi gran amiga María José Gil Morrió, con quien he compartido todos estos años de trabajo y con la cual me unen muchos lazos de amistad y cariño. De igual manera mis más sinceras gracias a Puri y a Ernesto, ambos han sido muy importantes en mi vida desde que llegue a Valencia y con los cuales he compartido muchos ratos lindos. También hago extensivo este agradecimiento a Susi por todo el apoyo que me ha brindado y me sigue brindando hasta la fecha.A José Luis y a Astrid tampoco podría dejar de mencionar, pues ambos han compartido todo mi trabajo desde mis comienzos, siendo participes del día a día en el laboratorio, tanto a nivel personal como profesional.Para terminar una dedicación muy especial a la nueva generación incorporada en el grupo, en primer lugar y de manera muy especial a Vicentin por toda su ayuda y por brindarme siempre su amistad, a María José Castelló por soportarme, a mis colegas de las cervecitas de los viernes sobre todo Emilio, Jorge, Silvia y Brande, así como también a Albor, Elsa, Pablote y la gran Lorena. También quisiera incluir en este listado a Ana y María José Hernández, los dos últimos fichajes de Pablo Vera, que a pesar de haber compartido muy poco con ellas, me han ofrecido todo su apoyo.A Brigitte Mauch Mani y a Victor Flors por haber colaborado en todos los experimentos con hongos fitopátogenos.En fin deseo agradecer a todos aquellos que de una forma u otra han aportado su granito de arena en este trabajo. A todos muchas gracias por los momentos pasados.Como no todo es trabajo en esta vida, no podría dejar de mencionar a mi Margarita y mucho menos a mis dos retoños, Ale y Dani. Tampoco podría olvidar a mis padres, y a mis amigos Hector, Eduardo, Pedro y Marcelo, todos ellos han sufrido las penas y glorias de toda esta etapa y sin los cuales no hubiera sido posible llegar al final.A todo el personal de apoyo del invernadero y del IBMCP, a todos muchas gracias. RESUMENLa mancha bact...

show abstract

Aging and senescence of the leaf organ

Lim¹,

Nam

2007

J. Plant Biol.

Self Cite

View full text Add to dashboard Cite

Leaf senescence is a sequence of biochemical and physiological events comprising the final stage in leaf development. It encompasses the period from a fully expanded mature state up to the death, thereby limiting longevity. The changes occurring during leaf senescence are very complex but highly regulated, and are genetically programmed with actions coordinated at the cellular, tissue, organ, and organism levels. A major breakthrough in our molecular understanding of this phenomenon has been achieved through the characterization of various mutants and senescence-associated genes, including regulatory genes. In particular, a genetic screening and assay system for leaf senescence has been well established in Arabidopsis, which led leaf senescence into the realm of genetic subject along with the rich genetic and genomic resources in this model plant. These advances have not only revealed the existence of a complex regulatory network of senescence-associated signaling pathways, but have also allowed us to postulate the molecular mechanisms for signal perception, execution, and regulation. The key regulatory genes identified to date encode a variety of proteins, including transcription regulators and signal-transduction proteins, regulators of protein degradation, proteins associated with phytohormone pathways, and regulators of metabolism. Elucidation of their roles in leaf senescence and analyses of senescence regulatory pathways, including systemslevel approaches, will increase our knowledge of the networks involved in senescence activity.

show abstract

ORE9, an F-Box Protein That Regulates Leaf Senescence in Arabidopsis

Cited by 47 publications

References 0 publications

The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis

The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis

Análisis funcional del gen Ep5C y su implicación en los mecanismos de defensa en plantas

Aging and senescence of the leaf organ

Contact Info

Product

Resources

About