2011
DOI: 10.1016/j.bbr.2010.08.017
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Orexin-1 receptor mediates long-term potentiation in the dentate gyrus area of freely moving rats

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Cited by 58 publications
(31 citation statements)
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“…A selective blockade of the orexin 1 receptor remarkably impaired the acquisition and consolidation of spatial memory in the Morris water maze (Akbari, Naghdi & Motamedi 2006). It was also reported that orexin A mediated long-term potentiation expression in the DG (Wayner et al 2004;Akbari et al 2011). Recently, Ito et al suggested that orexin A induced an antidepressive-like effect via the enhancement of cell proliferation in the DG (Ito et al 2008).…”
Section: Discussionmentioning
confidence: 93%
“…A selective blockade of the orexin 1 receptor remarkably impaired the acquisition and consolidation of spatial memory in the Morris water maze (Akbari, Naghdi & Motamedi 2006). It was also reported that orexin A mediated long-term potentiation expression in the DG (Wayner et al 2004;Akbari et al 2011). Recently, Ito et al suggested that orexin A induced an antidepressive-like effect via the enhancement of cell proliferation in the DG (Ito et al 2008).…”
Section: Discussionmentioning
confidence: 93%
“…Orexin neurons appear to synapse directly on basal forebrain cholinergic neurons important in cognition (Castillo-Ruiz et al, 2010; Fadel et al, 2005; Frederick-Duus et al, 2007), and orexin appears to mediate long-term potentiation in the dentate gyrus of the hippocampus (Akbari et al, 2011). Prior work utilizing operant tasks shows that supplementing orexin might affect cognitive processes (Choi et al, 2010; Sharf et al, 2010; Thorpe et al, 2005).…”
Section: Discussionmentioning
confidence: 99%
“…Previously, a link between DAG and the orexin pathway was shown in relation to feeding (Toshinai et al, 2006) and the orexin family seems to be involved in epileptic mechanisms (Akbari et al, 2014;Akdogan et al, 2008;Doreulee et al, 2010;Erken et al, 2012;Kortunay et al, 2012;Rejdak et al, 2009). It is thought that orexin release in the hippocampus may be excitatory (Akbari et al, 2011;Ida et al, 1999;Selbach et al, 2004;Wayner et al, 2004). The effect of simultaneous orexin receptor antagonism in epileptic seizure models was never investigated, thus we first determined whether blocking the effect of orexins via the dual orexin receptor antagonist almorexant affected pilocarpine-induced limbic seizures.…”
Section: Article In Pressmentioning
confidence: 95%
“…For instance, the neuropeptide ghrelin has been documented to be excitatory in the hippocampus yet it has repeatedly been shown that it possesses anticonvulsant properties when tested in different seizure models (Portelli et al, 2012a). Another hypothesis could be that orexin-A and orexin-B seem to have opposing actions in epilepsy (Akbari et al, 2011;Doreulee et al, 2010;Ida et al, 1999;Selbach et al, 2004;Wayner et al, 2004), and by blocking both receptors simultaneously the excitatory effect of one ligand is being hindered by the inhibitory effect of the other.…”
Section: Article In Pressmentioning
confidence: 95%