Orexin one receptors within the basolateral amygdala are involved in the modulation of cognitive deficits associated with a migraine-like state in rats

Askari-Zahabi, Khadijeh; Abbasnejad, Mehdi; Kooshki, Razieh; Esmaeili‐Mahani, Saeed

doi:10.1080/01616412.2021.1949687

Cited by 7 publications

(4 citation statements)

References 59 publications

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“…To understand the neural mechanisms of the stereotyped behaviors, the proper and correlated phenotype in animal models is necessary. Self-grooming is a common stereotyped behavior that is observed in many animal species, especially rodents ( Arakawa, 2021 ; Askari-Zahabi et al, 2021 ). It follows an innate cephalo-caudal progression, beginning with paw licking, then nose/face/head washing, body grooming, leg licking, and finally tail/genitals grooming, which display subtle hierarchical motor control ( Kalueff et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model

Liu

Huang

et al. 2021

Neurobiology of Stress

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Section: Introductionmentioning

confidence: 99%

Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model

Liu

Huang

et al. 2021

Neurobiology of Stress

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“…Behavioral analyses of mechanical allodynia have revealed recovery after cAMP/PKA/CREB signaling is inhibited with a PKA inhibitor, suggesting that the effects of the PKA inhibitor may occur through regulation of mechanical allodynia [32]. Interestingly, the PKA inhibitors H-89 and PKI (14)(15)(16)(17)(18)(19)(20)(21)(22) can block the regulation of CGRP release and regulate pain sensitization [33].…”

Section: Discussionmentioning

confidence: 99%

“…Head grooming behavior refers to cleaning the head/face with the frontpaws or hind paws. One of the indexes of spontaneous facial pain is to increase the time spent on head grooming [ 16 ].We used a video camera to record that. The time it spent grooming its head was calculated.…”

Section: Methodsmentioning

confidence: 99%

Perampanel ameliorates nitroglycerin-induced migraine through inhibition of the cAMP/PKA/CREB signaling pathway in the trigeminal ganglion in rats

et al. 2023

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Background Perampanel, a highly selective glutamate AMPA receptor antagonist, is widely used to treat epilepsy. Since the existence of common pathophysiological features between epilepsy and migraine, the aim of this study was to investigate whether perampanel could exert an antimigraine effect. Methods Nitroglycerin (NTG) was used to induce a migraine model in rats, and the model animals were pretreatment with 50 μg/kg and 100 μg/kg perampanel. The expression of pituitary adenylate-cyclase-activating polypeptide (PACAP) was quantified by western blot and quantitative real-time PCR in the trigeminal ganglion, and rat-specific enzyme-linked immunosorbent assay in serum. Western blot was also conducted to explore the effects of perampanel treatment on the phospholipase C (PLC)/protein kinase C (PKC) and protein kinase A (PKA)/cAMP-responsive-element-binding protein (CREB) signaling pathways. Moreover, the cAMP/PKA/CREB-dependent mechanism was evaluated via in vitro stimulation of hippocampal neurons. The cells were treated with perampanel, antagonists and agonists for 24 hours and cell lysates were prepared for western blot analysis. Results Perampanel treatment notably increased the mechanical withdrawal threshold and decreased head grooming and light-aversive behaviors in NTG-treated rats. It also decreased PACAP expression and affected cAMP/PKA/CREB signaling pathway. However, PLC/PKC signaling pathway may not be involved in this treatment. In in vitro studies, perampanel notably decreased PACAP expression by inhibiting cAMP/PKA/CREB signaling pathway. Conclusions This study shows that perampanel inhibits the migraine-like pain response and that this beneficial effect might be attributable to regulation of the cAMP/PKA/CREB signaling pathway.

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“…In many animal experiments, the amygdale and the periaqueductal gray matter (GM) have also been shown involved in regulating the behavior of migraine. A study suggests an emerging role of the basolateral amygdala in regulating cognitive decline in coexisting migraine headaches in rats (Askari‐Zahabi et al., 2021). One study suggests that the ventrolateral periaqueductal GM is involved in modulating anxiety‐like behaviors and social dysfunction in migraineur rats (Pourrahimi et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

Alterations of amygdala volume and functional connectivity in migraine patients comorbid with and without depression

Chen,

Gui,

et al. 2024

Brain and Behavior

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ObjectiveThe comorbid relationship between migraine and depression has been well recognized, but its underlying pathophysiology is unclear. Here, we aimed to explore the structural changes of the amygdala and the abnormal functional connectivity of the centromedial amygdala (CMA) in migraineurs with depression.MethodsHigh‐resolution T1‐weighted and functional magnetic resonance images were acquired from 22 episodic migraineurs with comorbid depression (EMwD), 21 episodic migraineurs without depression (EM), and 17 healthy controls (HC). Voxel‐based morphometry and resting‐state functional connectivity (rsFC) were applied to examine the intergroup differences in amygdala volume.ResultsThe bilateral amygdala volume was increased in the EMwD and EM groups compared with the HC group, but there were no differences between the EMwD and EM groups. The right CMA exhibited decreased rsFC in the left dorsolateral prefrontal cortex (DLPFC) in the EMwD group compared with the EM group, while rsFC increased between the CMA and the contralateral DLPFC in the EM group compared with the HC group. In addition, the EM group showed decreased rsFC between the left CMA and the left pallidum compared with the HC group.ConclusionsEnlarged amygdala is an imaging feature of EM and EMwD. The inconsistency of rsFC between CMA and DLPFC between migraineurs with and without depression might indicate that decreased rsFC between CMA and DLPFC is a neuropathologic marker for the comorbidity of migraine and depression. The core regions might be a potential intervention target for the treatment of EMwD in the future.

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Orexin one receptors within the basolateral amygdala are involved in the modulation of cognitive deficits associated with a migraine-like state in rats

Cited by 7 publications

References 59 publications

Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model

Dissection of the relationship between anxiety and stereotyped self-grooming using the Shank3B mutant autistic model, acute stress model and chronic pain model

Perampanel ameliorates nitroglycerin-induced migraine through inhibition of the cAMP/PKA/CREB signaling pathway in the trigeminal ganglion in rats

Alterations of amygdala volume and functional connectivity in migraine patients comorbid with and without depression

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