Organ and Metabolic Complications: Trace Elements

Alfrey, Allen C.

doi:10.1007/978-0-585-36947-1_53

Cited by 2 publications

(1 citation statement)

References 83 publications

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“…5-7 Therefore, regular measurement of serum and dialysis fluid aluminum concentration is of considerable value in order to determine aluminum exposure and as a guide to the risk of toxicity in long-term haemodialysis patients. 7,8 Atomic absorption spectroscopy (AAS) is the method most widely used for routine aluminum determination in plasma or serum. 9,10 Nevertheless, several investigators have applied neutron activation analysis to determine aluminum content in biological materials.…”

Section: Introductionmentioning

confidence: 99%

Serum aluminum determination by instrumental neutron activation analysis in long-term haemodialysis patients

Stamatelatos

Katopodis

Bersos

et al. 1999

J Radioanal Nucl Chem

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Serum aluminum levels were determined by instrumental neutron activation analysis in 31 patients undergoing long-term haemodialysis. Aluminum-28 1.778 MeV (Tj/2 = 2.24 min) "/-rays produced by the thermal neutron reaction 27Al(n,'f)28AI were detected. Successive irradiation of the samples at epithermal neutron fluence was performed to correct for the interference from the fast neutron reaction 3tp(n,cQ28Al. Serum aluminum level in this group of subjects was adequately represented by a lognormal distribution with a mean and variance of 16.5 ~tg/l and 16.8 gg/I, respectively. The results obtained were found to be in agreement with serum aluminum determination performed by electrothermal atomic absorption spectrophotometry (r 2 = 0.97). Instrumental neutron activation can provide a rapid technique to routinely monitor long-term haemodialysis patients in order to identify individuals at greater risk to develop aluminum toxicity.

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Section: Introductionmentioning

confidence: 99%