Organ bioprinting: progress, challenges and outlook

Wu, Yang; Qin, Minghao; Yang, Xue

doi:10.1039/d3tb01630g

Cited by 6 publications

(3 citation statements)

References 196 publications

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“…Organ-on-a-chip platforms offer great versatility to generate spatially organized tissue-constructs in the microscale. However, they struggle to generate the large 3D organ architectures that would be needed for skin or tissue transplantation (Rothbauer et al, 2022;Wu et al, 2023). State-of-the-art technologies, such as 3D bioprinting, may be able to fulfill this need.…”

Section: Bioprinted Skin Constructsmentioning

confidence: 99%

Moving lab-grown tissues into the clinic: organ-on-a-chip and bioengineered skin systems

Reed-McBain,

Patel,

Reed-McBain

et al. 2024

Front. Lab. Chip. Technol.

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For patients with end stage organ failure, organ transplant is frequently the only curative option available. However, organs available for transplant are in critically short supply around the world, which has led to lengthy wait times and increased mortality. Increased global life expectancy, coupled with raised age thresholds for recipients, has heightened demand and further compounded the need for alternative strategies. Bioengineering substitutes including organ-on-a-chip and 3D bioprinting technologies have made considerable strides toward whole organ generation. Skin is the organ where the most advances have been made thus far, due to the relatively less complex spatial architecture and industry interest in the development of sophisticated models for pharmaceutical and cosmetics testing. Here, we discuss the challenges of recapitulating the complexity of native skin, including a stratified structure, vascularization, and inclusion of skin appendages, such as hair follicles and sweat glands. We discuss current technological and biological progress in the field of tissue and organ bioengineering as well as highlight future challenges to generate de novo tissue for skin grafting.

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Section: Bioprinted Skin Constructsmentioning

confidence: 99%

Moving lab-grown tissues into the clinic: organ-on-a-chip and bioengineered skin systems

Reed-McBain,

Patel,

Reed-McBain

et al. 2024

Front. Lab. Chip. Technol.

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show abstract

“…The construction scheme is complex, and the adjustment of parameters mainly relies on repeated trials, which is time-consuming. However, organoid structure and morphology can be precisely regulated, and highly complex organs can be printed [ 110 ]. The advantage of self-assembly construction scheme to construct organoids is that it is relatively straightforward to operate.…”

Section: Cardiovascular Organoid Construction Schemementioning

confidence: 99%

Progress of organoid platform in cardiovascular research

Du,

Jia,

Chang

et al. 2024

Bioactive Materials

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“…In the biomedical domain, 3D printing has established itself as a versatile technology with diverse applications including, but not limited to, regenerative medicine, 27–29 microneedle-based drug/vaccine patches, 30–33 flexible bioelectronics, 34–36 biohybrid actuators, 37–39 customized implants and prosthetics, 40–43 and specialized surgical tools. 44–46 3D bioprinting has received widespread attention owing to its robust capabilities in recapitulating biomimetic tissue constructs for regenerative medicine, 47–51 as well as for developing organotypic models for toxicology, disease modeling, and drug discovery.…”

Section: Introductionmentioning

confidence: 99%